Sec Form 3 Filing - Venrock Healthcare Capital Partners II, L.P. @ VistaGen Therapeutics, Inc. - 2022-04-06

FORM 3 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Venrock Healthcare Capital Partners II, L.P. 2. Issuer Name and Ticker or Trading Symbol VistaGen Therapeutics, Inc. [ VTGN] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director X __ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) C/O VENROCK, 3340 HILLVIEW AVENUE 3. Date of Earliest Transaction (MM/DD/YY) 04/06/2022 (Street) PALO ALTO, CA94304 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) _____ Form filed by One Reporting Person __ X __ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 20,697,286( 1 ) I By Funds( 2 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Venrock Healthcare Capital Partners I I, L.P. C/O VENROCK 3340 HILLVIEW AVENUE PALO ALTO, CA94304 X VHCP Co-Investment Holdings II, LLC C/O VENROCK 3340 HILLVIEW AVENUE PALO ALTO, CA94304 X VHCP Management II, LLC C/O VENROCK 3340 HILLVIEW AVENUE PALO ALTO, CA94304 X Venrock Healthcare Capital Partners III, L.P. C/O VENROCK 3340 HILLVIEW AVENUE PALO ALTO, CA94304 X VHCP Co-Investment Holdings III, LLC C/O VENROCK 3340 HILLVIEW AVENUE PALO ALTO, CA94304 X VHCP Management III, LLC C/O VENROCK 3340 HILLVIEW AVENUE PALO ALTO, CA94304 X Venrock Healthcare Capital Partners EG, L.P. C/O VENROCK 3340 HILLVIEW AVENUE PALO ALTO, CA94304 X VHCP Management EG, LLC C/O VENROCK 3340 HILLVIEW AVENUE PALO ALTO, CA94304 X Koh Bong Y C/O VENROCK 3340 HILLVIEW AVENUE PALO ALTO, CA94304 X Shah Nimish P C/O VENROCK 3340 HILLVIEW AVENUE PALO ALTO, CA94304 X Signatures /s/ David L. Stepp, Authorized Signatory 07/08/2022 Signature of Reporting Person Date David L. Stepp, Authorized Signatory 07/08/2022 Signature of Reporting Person Date David L. Stepp, Authorized Signatory 07/08/2022 Signature of Reporting Person Date David L. Stepp, Authorized Signatory 07/08/2022 Signature of Reporting Person Date David L. Stepp, Authorized Signatory 07/08/2022 Signature of Reporting Person Date David L. Stepp, Authorized Signatory 07/08/2022 Signature of Reporting Person Date David L. Stepp, Authorized Signatory 07/08/2022 Signature of Reporting Person Date David L. Stepp, Authorized Signatory 07/08/2022 Signature of Reporting Person Date David L. Stepp, Attorney-in-fact 07/08/2022 Signature of Reporting Person Date David L. Stepp, Attorney-in-fact 07/08/2022 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Consists of 4,949,368 shares held by Venrock Healthcare Capital Partners II, L.P. ("VHCP II"), 2,005,785 shares held by VHCP Co-Investment Holdings II, LLC ("VHCP II Co"), 1,617,270 shares held by Venrock Healthcare Capital Partners III, L.P. ("VHCP III"), 161,820 shares held by VHCP Co-Investment Holdings III, LLC ("VHCP III Co") and 11,963,043 shares held by Venrock Healthcare Capital Partners EG, L.P. ("VHCP EG"). ( 2 )VHCP Management II, LLC ("VHCPM II") is the sole general partner of VHCP II and the sole manager of VHCP II Co. VHCP Management III, LLC ("VHCPM III") is the sole general partner of VHCP III and the sole manager of VHCP III Co. VHCP Management EG, LLC ("VHCPM EG") is the sole general partner of VHCP EG. Dr. Bong Koh and Nimish Shah are the voting members of VHCPM II, VHCPM III and VHCPM EG. Dr. Koh, Mr. Shah, VHCPM II, VHCPM III and VHCPM EG disclaim beneficial ownership over all shares held by VHCP II, VHCP II Co, VHCP III, VHCP III Co and VHCP EG, except to the extent of their respective indirect pecuniary interests therein.

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