Sec Form 3 Filing - Burris Mei Zhang Lu @ PRECISION BIOSCIENCES INC - 2026-08-01

FORM 3 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Burris Mei Zhang Lu 2. Issuer Name and Ticker or Trading Symbol PRECISION BIOSCIENCES INC [ DTIL] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner X __ Officer (give title below) _____ Other (specify below) Chielf Accounting Officer (Last) (First) (Middle) C/O PRECISION BIOSCIENCES, INC., 302 E. PETTIGREW STREET, SUITE A-100 3. Date of Earliest Transaction (MM/DD/YY) 08/01/2026 (Street) DURHAM, NC27701 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 5,115 D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Employee Stock Option (Right to Buy) $ 378 ( 1 ) 05/01/2029 Common Stock 945 D Employee Stock Option (Right to Buy) $ 174.9 ( 1 ) 08/20/2030 Common Stock 214 D Employee Stock Option (Right to Buy) $ 340.2 ( 1 ) 06/06/2031 Common Stock 403 D Employee Stock Option (Right to Buy) $ 122.4 ( 1 ) 03/02/2032 Common Stock 778 D Restricted Stock Units ( 3 ) ( 2 ) ( 2 ) Common Stock 11,288 D Restricted Stock Units ( 3 ) ( 4 ) ( 4 ) Common Stock 30,129 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Burris Mei Zhang Lu C/O PRECISION BIOSCIENCES, INC. 302 E. PETTIGREW STREET, SUITE A-100 DURHAM, NC27701 Chielf Accounting Officer Signatures /s/ Dario Scimeca, Attorney-in-Fact for Mei Burris 08/03/2026 Signature of Reporting Person Date

Explanation of Responses:

( 1 )The stock options are fully vested and exercisable as of the date of this report. ( 2 )On July 24, 2025, the reporting person was granted 16,932 restricted stock units ("RSUs"), which vest in three substantially equal annual installments beginning on February 24, 2026, subject to the Reporting Person's continued service to the Company through the applicable vesting dates. ( 3 )The Reporting Person was granted RSUs, which each represents a contingent right to receive one share of the Company's Common Stock. ( 4 )On June 1, 2026, the reporting person was granted 30,129 RSUs, which vest in three substantially equal annual installments beginning on February 22, 2027, subject to the Reporting Person's continued service to the Company through the applicable vesting dates.

Remarks: Exhibit 24 - Power of Attorney

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

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