Sec Form 3 Filing - TEACHERS INSURANCE & ANNUITY ASSOCIATION OF AMERICA @ Kayne Anderson MLP/Midstream Investment Co - 2019-04-16

FORM 3 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL OMB Number: 3235-0287 Expires: November 30, 2011 Estimated average burden hours per response... 0.5

1. Name and Address of Reporting Person TEACHERS INSURANCE & ANNUITY ASSOCIATION OF AMERICA 2. Issuer Name and Ticker or Trading Symbol Kayne Anderson MLP/Midstream Investment Co [ KYN] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director X __ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) 730 THIRD AVE 3. Date of Earliest Transaction (MM/DD/YY) 04/16/2019 (Street) NEW YORK, NY10017 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price 3.46% Series OO Senior Unsecured Notes due October 29, 2024 $ 22,000,000 ( 1 ) D 3.57% Series FF Senior Unsecured Notes due April 16, 2023 $ 6,000,000 D 3.67% Series GG Senior Unsecured Notes due April 16, 2025 $ 7,000,000 D 3.93% Series KK Senior Unsecured Notes due July 30, 2024 $ 17,000,000 D 3.95% Series CC Senior Unsecured Notes due May 3, 2022 $ 16,000,000 D Series H Mandatory Redeemable Preferred Shares 440,000 D Series I Mandatory Redeemable Preferred Shares 160,000 D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other TEACHERS INSURANCE & ANNUITY ASSOCIATION OF AMERICA 730 THIRD AVE NEW YORK, NY10017 X Signatures By: Nuveen Alternatives Advisors, LLC, its investment manager: By: /s/ Trevor Sanford, Associate General Counsel 01/02/2020 Signature of Reporting Person Date

Explanation of Responses:

( 1 )The Reporting Person is filing this Form 3 because, due solely to a redemption of senior unsecured notes by the Issuer on April 16, 2019, the Reporting Person's beneficial ownership of the Notes surpassed 10%.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.