Sec Form 3 Filing - Novack Jeffrey Adam @ CareDx, Inc. - 2024-04-24

FORM 3 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Novack Jeffrey Adam 2. Issuer Name and Ticker or Trading Symbol CareDx, Inc. [ CDNA] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner X __ Officer (give title below) _____ Other (specify below) Secretary and General Counsel (Last) (First) (Middle) C/O CAREDX, INC., 8000 MARINA BOULEVARD 3. Date of Earliest Transaction (MM/DD/YY) 04/24/2024 (Street) BRISBANE, CA94005 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 126,974 ( 1 ) D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Employee Stock Option (right to buy) $ 18.24 ( 2 ) 08/06/2032 Common Stock 2,385 D Employee Stock Option (right to buy) $ 37.25 ( 3 ) 04/06/2032 Common Stock 2,150 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Novack Jeffrey Adam C/O CAREDX, INC. 8000 MARINA BOULEVARD BRISBANE, CA94005 Secretary and General Counsel Signatures /s/ Jeffrey Adam Novack 05/03/2024 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Comprised of 7,341 shares of common stock and 119,633 shares of common stock represented by restricted stock units ("RSUs"). The RSUs consist of (1) 5,000 shares granted on November 6, 2021; (2) 7,150 shares granted on April 6, 2022; (3) 1,600 shares granted on August 6, 2022; (4) 11,655 shares granted on November 7, 2022; (5) 7,500 shares granted on April 6, 2023; (6) 10,000 shares granted on June 6, 2023; (7) 10,000 shares granted on July 6, 2023; and (8) 66,728 shares granted on February 1, 2024. Each of the foregoing RSU grants is subject to its own vesting schedule. ( 2 )The option was originally granted on August 6, 2022. 1/4th of the shares subject to the option vested on August 6, 2023 and 1/48th of the shares subject to the option shall vest monthly thereafter. ( 3 )The option was originally granted on April 6, 2022. 1/4th of the shares subject to the option vested on April 6, 2023 and 1/48th of the shares subject to the option shall vest monthly thereafter.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

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