Sec Form 4 Filing - Frieberg Jacob B. @ VACCINEX, INC. - 2023-06-30

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Frieberg Jacob B. 2. Issuer Name and Ticker or Trading Symbol VACCINEX, INC. [ VCNX] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) X __ Director _____ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) C/O VACCINEX, INC., 1895 MOUNT HOPE AVENUE 3. Date of Earliest Transaction (MM/DD/YY) 06/30/2023 (Street) ROCHESTER, NY14620 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 4,235 D Common Stock 6,301 I By Benbow Estates, Ltd. ( 1 ) Common Stock 12,870 I By Gee Eff Services Limited ( 2 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Stock Option (Right to Buy) $ 204 ( 3 ) 09/15/2027 Common Stock 6,396 6,396 D Stock Option (Right to Buy) $ 78.9 ( 3 ) 03/30/2029 Common Stock 2,501 2,501 D Stock Option (Right to Buy) $ 116.7 ( 3 ) ( 4 ) Common Stock 7,718 7,718 D Stock Option (Right to Buy) $ 82.8 ( 3 ) 06/29/2029 Common Stock 2,385 2,385 D Stock Option (Right to Buy) $ 107.55 ( 3 ) 09/27/2029 Common Stock 1,856 1,856 D Stock Option (Right to Buy) $ 72.75 ( 3 ) 12/28/2029 Common Stock 2,737 2,737 D Stock Option (Right to Buy) $ 60 ( 3 ) 03/29/2030 Common Stock 3,336 3,336 D Stock Option (Right to Buy) $ 59.25 ( 3 ) ( 5 ) Common Stock 15,679 15,679 D Stock Option (Right to Buy) $ 54.15 ( 3 ) 06/28/2030 Common Stock 3,756 3,756 D Stock Option (Right to Buy) $ 26.7 ( 3 ) 09/28/2030 Common Stock 7,626 7,626 D Stock Option (Right to Buy) $ 31.05 ( 3 ) 12/29/2030 Common Stock 6,545 6,545 D Stock Option (Right to Buy) $ 44.7 ( 3 ) 03/31/2031 Common Stock 4,535 4,535 D S tock Option (Right to Buy) $ 32.25 ( 3 ) ( 6 ) Common Stock 28,586 28,586 D Stock Option (Right to Buy) $ 42 ( 3 ) 06/28/2031 Common Stock 4,804 4,804 D Stock Option (Right to Buy) $ 32.4 ( 3 ) 09/28/2031 Common Stock 6,233 6,233 D Stock Option (Right to Buy) $ 15.6 ( 3 ) 12/29/2031 Common Stock 12,856 12,856 D Stock Option (Right to Buy) $ 19.8 ( 3 ) 03/28/2032 Common Stock 10,032 10,032 D Stock Option (Right to Buy) $ 16.8 ( 3 ) ( 7 ) Common Stock 53,254 53,254 D Stock Option (Right to Buy) $ 16.2 ( 3 ) 06/27/2032 Common Stock 12,064 12,064 D Stock Option (Right to Buy) $ 7.43 ( 3 ) 09/27/2032 Common Stock 26,260 26,260 D Stock Option (Right to Buy) $ 9.68 ( 3 ) 12/28/2032 Common Stock 19,852 19,852 D Stock Option (Right to Buy) $ 5.99 ( 3 ) 03/28/2033 Common Stock 32,107 32,107 D Stock Option (Right to Buy) $ 6.15 05/11/2024 ( 8 ) Common Stock 143,848 143,848 D Stock Option (Right to Buy) $ 5.34 06/30/2023 A 2,414 06/30/2023 06/27/2033 Common Stock 2,414 $ 3.62 ( 9 ) 2,414 D Stock Option (Right to Buy) $ 1.13 09/29/2023 A 11,291 09/29/2023 09/26/2033 Common Stock 11,291 $ 0.77 ( 10 ) 11,291 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Frieberg Jacob B. C/O VACCINEX, INC. 1895 MOUNT HOPE AVENUE ROCHESTER, NY14620 X Signatures /s/ Scott E. Royer, Attorney-in-Fact for Jacob B. Frieberg 10/05/2023 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Mr. Frieberg's spouse is the owner of Benbow Estates, Ltd. and Mr. Frieberg is an officer of Benbow Estates, Ltd. Mr. Frieberg disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein. ( 2 )Mr. Frieberg is the sole owner and President of Gee Eff Services Limited. ( 3 )Exercisable in full as of the date of this report. ( 4 )This option expires on May 14, 2029 or five years following retirement or cessation of services, whichever occurs first. ( 5 )This option expires on May 12, 2030 or five years following retirement or cessation of services, whichever occurs first. ( 6 )This option expires on May 9, 2031 or five years following retirement or cessation of services, whichever occurs first. ( 7 )This option expires on May 9, 2032 or five years following retirement or cessation of services, whichever occurs first. ( 8 )This option expires on May 8, 2033 or five years following retirement or cessation of services, whichever occurs first. ( 9 )Pursuant to the Issuer's Director Compensation Plan, in a transaction exempt under Rule 16b-3, the reporting person elected to receive these options in lieu of $8,750 for retainer and meeting fees during the second quarter of 2023. The number of options was calculated in accordance with the Black-Scholes valuation model and all such options are immediately exercisable. ( 10 )Pursuant to the Issuer's Director Compensation Plan, in a transaction exempt under Rule 16b-3, the reporting person elected to receive these options in lieu of $8,750 for retainer and meeting fees during the third quarter of 2023. The number of options was calculated in accordance with the Black-Scholes valuation model and all such options are immediately exercisable.

Remarks: On September 25, 2023, Vaccinex, Inc. effected a 1-for-15 reverse stock split (the "Reverse Stock Split"). All figures in this Form 4 reflect the Reverse Stock Split.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

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