Sec Form 13G Filing - FMR LLC filing for 10x Genomics Inc. (TXG) - 2024-02-09

Insider filing report for Changes in Beneficial Ownership

  • Schedule 13G & 13D forms are used to report a party's ownership of stock which exceeds 5% of a company's total stock issue.
  • Schedule 13G is a shorter version of Schedule 13D with fewer reporting requirements.
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SCHEDULE 13G

Amendment No.7
10X GENOMICS INC
CLASS A COMMON STOCK
Cusip #88025U109
Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:
[x] Rule 13d-1(b)
[ ] Rule 13d-1(c)
[ ] Rule 13d-1(d)

Cusip #88025U109
Item 1: Reporting Person - FMR LLC
Item 2: (a)  [ ]
        (b)  [ ]
Item 4: Delaware
Item 5: 17,711,545
Item 6: 0
Item 7: 17,731,269
Item 8: 0
Item 9: 17,731,269
Item 11: 16.252%
Item 12: HC

Cusip #88025U109
Item 1: Reporting Person - Abigail P. Johnson
Item 2: (a)  [ ]
        (b)  [ ]
Item 4: United States of America
Item 5: 0
Item 6: 0
Item 7: 17,731,269
Item 8: 0
Item 9: 17,731,269
Item 11: 16.252%
Item 12: IN
4,945,733 of the shares of Class A Common Stock of 10X GENOMICS INC
reported as being beneficially owned by the reporting persons at
December 29, 2023, are included in this Schedule 13G because the
Reporting persons are deemed to beneficially own such shares as a
result of the direct ownership of 4,945,733 shares of Class B Common
Stock of 10X GENOMICS INC by investment companies advised by
Fidelity Management & Research Company LLC and Fidelity Management
Trust Company, indirect wholly-owned subsidiaries of FMR LLC as of
such date, which shares of Class B Common Stock are convertible
into shares of Class A Common Stock at the election of the holder at
an exchange rate of 1:1. Such shares of Class B Common Stock
represent 35.183% of the outstanding Class B Common Stock.
Assuming the conversion of all outstanding shares of Class B
Common Stock into Class A Common Stock, the 12,785,536
shares of Class A Common Stock reported as being beneficially
owned by the reporting persons in this Schedule 13G would
represent 15.000% of the outstanding Class A Common Stock.


Item 1(a). Name of Issuer:

10X GENOMICS INC

Item 1(b). Address of Issuer's Principal Executive Offices:

6230 STONERIDGE MALL ROAD
PLEASANTON, CA 94588
USA

Item 2(a). Name of Person Filing:

FMR LLC

Item 2(b). Address or Principal Business Office or, if None, Residence:

245 Summer Street, Boston, Massachusetts 02210

Item 2(c). Citizenship:

Not applicable

Item 2(d). Title of Class of Securities:

CLASS A COMMON STOCK

Item 2(e). CUSIP Number:

88025U109

Item 3. This statement is filed pursuant to Rule 13d-1(b) or 13d-2(b) or (c)
and the person filing, FMR LLC, is a parent holding company in accordance with
Section 240.13d-1(b)(1)(ii)(G). (Note: See Exhibit A).

Item 4. Ownership

(a) Amount Beneficially Owned: 17,731,269

(b) Percent of Class: 16.252%

(c) Number of shares as to which such person has:

(i) sole power to vote or to direct the vote: Please see the responses to
Items 5 and 6 on the cover page

(ii) shared power to vote or to direct the vote: 0

(iii) sole power to dispose or to direct the disposition of: 17,731,269

(iv) shared power to dispose or to direct the disposition of: 0

4,945,733 of the shares of Class A Common Stock of 10X GENOMICS INC
reported as being beneficially owned by the reporting persons at
December 29, 2023, are included in this Schedule 13G because the
Reporting persons are deemed to beneficially own such shares as a
result of the direct ownership of 4,945,733 shares of Class B Common
Stock of 10X GENOMICS INC by investment companies advised by
Fidelity Management & Research Company LLC and Fidelity Management
Trust Company, indirect wholly-owned subsidiaries of FMR LLC as of
such date, which shares of Class B Common Stock are convertible
into shares of Class A Common Stock at the election of the holder at
an exchange rate of 1:1. Such shares of Class B Common Stock
represent 35.183% of the outstanding Class B Common Stock.
Assuming the conversion of all outstanding shares of Class B
Common Stock into Class A Common Stock, the 12,785,536
shares of Class A Common Stock reported as being beneficially
owned by the reporting persons in this Schedule 13G would
represent 15.000% of the outstanding Class A Common Stock.

Item 5. Ownership of Five Percent or Less of a Class.

Not applicable.

Item 6. Ownership of More than Five Percent on Behalf of Another Person.

One or more other persons are known to have the right to receive or the power
to direct the receipt of dividends from, or the proceeds from the sale of, the
CLASS A COMMON STOCK of 10X GENOMICS INC. No one other person's interest in
the CLASS A COMMON STOCK of 10X GENOMICS INC is more than five percent of the
total outstanding CLASS A COMMON STOCK.


Item 7. Identification and Classification of the Subsidiary Which Acquired the
Security Being Reported on By the Parent Holding Company.

See attached Exhibit A.

Item 8. Identification and Classification of Members of the Group.

Not applicable.

Item 9. Notice of Dissolution of Group.

Not applicable.

Item 10. Certifications.

By signing below I certify that, to the best of my knowledge and belief,
the securities referred to above were acquired and are held in the ordinary
course of business and were not acquired and are not held for the purpose of
or with the effect of changing or influencing the control of the issuer of the
securities and were not acquired and are not held in connection with or as a
participant in any transaction having that purpose or effect.

Signature

After reasonable inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and
correct.

February 8, 2024
Date

/s/ Stephanie J. Brown
Signature

Stephanie J. Brown
Duly authorized under Power of Attorney effective as of January 3, 2023, by
and on behalf of FMR LLC and its direct and indirect subsidiaries*

* This power of attorney is incorporated herein by reference to Exhibit 24 to
the Schedule 13G filed by FMR LLC on January 10, 2023, accession number:
0000315066-23-000003.


Exhibit A


Pursuant to the instructions in Item 7 of Schedule 13G, the following table
lists the identity and Item 3 classification, if applicable, of each relevant
entity that beneficially owns shares of the security class being reported on
this Schedule 13G.

Entity   ITEM 3 Classification

FIAM LLC  IA
Fidelity Institutional Asset Management Trust Company  BK
Fidelity Management & Research Company LLC * IA
Fidelity Management Trust Company  BK
Strategic Advisers LLC  IA


* Entity beneficially owns 5% or greater of the outstanding shares of the
security class being reported on this Schedule 13G.


Abigail P. Johnson is a Director, the Chairman and the Chief Executive Officer
of FMR LLC.

Members of the Johnson family, including Abigail P. Johnson, are the
predominant owners, directly or through trusts, of Series B voting common
shares of FMR LLC, representing 49% of the voting power of FMR LLC. The
Johnson family group and all other Series B shareholders have entered into a
shareholders' voting agreement under which all Series B voting common shares
will be voted in accordance with the majority vote of Series B voting common
shares. Accordingly, through their ownership of voting common shares and the
execution of the shareholders' voting agreement, members of the Johnson family
may be deemed, under the Investment Company Act of 1940, to form a controlling
group with respect to FMR LLC.

This filing reflects the securities beneficially owned, or that may be deemed
to be beneficially owned, by FMR LLC, certain of its subsidiaries and
affiliates, and other companies (collectively, the "FMR Reporters"). This
filing does not reflect securities, if any, beneficially owned by certain
other companies whose beneficial ownership of securities is disaggregated from
that of the FMR Reporters in accordance with Securities and Exchange
Commission Release No. 34-39538 (January 12, 1998).


RULE 13d-1(k)(1) AGREEMENT

The undersigned persons, on February 8, 2024, agree and consent to the joint
filing on their behalf of this Schedule 13G in connection with their
beneficial ownership of the CLASS A COMMON STOCK of 10X GENOMICS INC at
December 29, 2023.

FMR LLC

By /s/ Stephanie J. Brown
Stephanie J. Brown
Duly authorized under Power of Attorney effective as of January 3, 2023, by
and on behalf of FMR LLC and its direct and indirect subsidiaries*

Abigail P. Johnson

By /s/ Stephanie J. Brown
Stephanie J. Brown
Duly authorized under Power of Attorney effective as of January 26, 2023, by
and on behalf of Abigail P. Johnson**


* This power of attorney is incorporated herein by reference to Exhibit 24 to
the Schedule 13G filed by FMR LLC on January 10, 2023, accession number:
0000315066-23-000003.

** This power of attorney is incorporated herein by reference to Exhibit 24 to
the Schedule 13G filed by FMR LLC on January 31, 2023, accession number:
0000315066-23-000038.