Sec Form 13G Filing - FIL Ltd filing for Structure Therapeutics Inc. (GPCR) - 2023-02-10

Insider filing report for Changes in Beneficial Ownership

  • Schedule 13G & 13D forms are used to report a party's ownership of stock which exceeds 5% of a company's total stock issue.
  • Schedule 13G is a shorter version of Schedule 13D with fewer reporting requirements.
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SCHEDULE 13G

Amendment No.  0
STRUCTURE THERAPEUTICS INC
COMMON STOCK
Cusip #JQD059000
Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:
[ ] Rule 13d-1(b)
[x] Rule 13d-1(c)
[ ] Rule 13d-1(d)

Cusip #JQD059000
Item 1: Reporting Person - FIL Limited
Item 2: (a)  [ ]
        (b)  [ ]
Item 4: Bermuda
Item 5: 6,473,761
Item 6: 0
Item 7: 6,473,761
Item 8: 0
Item 9: 6,473,761
Item 11: 5.897%
Item 12: FI

Cusip #JQD059000
Item 1: Reporting Person - Pandanus Partners, L.P.
Item 2: (a)  [ ]
        (b)  [ ]
Item 4: Delaware
Item 5: 0
Item 6: 0
Item 7: 6,473,761
Item 8: 0
Item 9: 6,473,761
Item 11: 5.897%
Item 12: PN

Cusip #JQD059000
Item 1: Reporting Person - Pandanus Associates, Inc.
Item 2: (a)  [ ]
        (b)  [ ]
Item 4: Delaware
Item 5: 0
Item 6: 0
Item 7: 6,473,761
Item 8: 0
Item 9: 6,473,761
Item 11: 5.897%
Item 12: CO



Item 1(a). Name of Issuer:

STRUCTURE THERAPEUTICS INC

Item 1(b). Address of Issuer's Principal Executive Offices:

611 GATEWAY BLVD, SUITE 223
SOUTH SAN FRANCISCO, CA 94080
USA

Item 2(a). Name of Person Filing:

FIL Limited

Item 2(b). Address or Principal Business Office or, if None, Residence:

Pembroke Hall, 42 Crow Lane, Hamilton, Bermuda, HM19

Item 2(c). Citizenship:

Not applicable

Item 2(d). Title of Class of Securities:

COMMON STOCK

Item 2(e). CUSIP Number:

JQD059000

Item 3. Not Applicable



Item 4. Ownership

(a) Amount Beneficially Owned: 6,473,761

(b) Percent of Class: 5.897%

(c) Number of shares as to which such person has:

(i) sole power to vote or to direct the vote: 6,473,761

(ii) shared power to vote or to direct the vote: 0

(iii) sole power to dispose or to direct the disposition of: 6,473,761

(iv) shared power to dispose or to direct the disposition of: 0


Item 5. Ownership of Five Percent or Less of a Class.

Not applicable.

Item 6. Ownership of More than Five Percent on Behalf of Another Person.

One or more other persons are known to have the right to receive or the power
to direct the receipt of dividends from, or the proceeds from the sale of, the
COMMON STOCK of STRUCTURE THERAPEUTICS INC. No one other person's interest in
the COMMON STOCK of STRUCTURE THERAPEUTICS INC is more than five percent of
the total outstanding COMMON STOCK.

Item 7. Identification and Classification of the Subsidiary Which Acquired the
Security Being Reported on By the Parent Holding Company.

See attached Exhibit A.

Item 8. Identification and Classification of Members of the Group.

Not applicable.

Item 9. Notice of Dissolution of Group.

Not applicable.

Item 10. Certifications.

By signing below I certify that, to the best of my knowledge and belief, the
securities referred to above were not acquired and are not held for the
purpose of or with the effect of changing or influencing the control of the
issuer of the securities and were not acquired and are not held in connection
with or as a participant in any transaction having that purpose or effect. By
signing below I certify that, to the best of my knowledge and belief, the
foreign regulatory scheme applicable to FIL Limited and its various non-U.S.
investment management subsidiaries included on this Schedule 13G is
substantially comparable to the regulatory scheme applicable to the
functionally equivalent U.S. institutions. I also undertake to furnish to the
Commission staff, upon request, information that would otherwise be disclosed
in a Schedule 13D.

Signature

After reasonable inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.

February 9, 2023
Date

/s/ Stephanie J. Brown
Signature

Stephanie J. Brown
Duly authorized under Power of Attorney effective as of December 19, 2022, by
and on behalf of FIL Limited and its direct and indirect subsidiaries*


* This power of attorney is incorporated herein by reference to Exhibit 24 to
the Schedule 13G filed by FIL Limited on January 31, 2023, accession number:
0000318989-23-000005.


Exhibit A


Pursuant to the instructions in Item 7 of Schedule 13G, the following table
lists the identity and Item 3 classification, if applicable, of each relevant
entity that beneficially owns shares of the security class being reported on
this Schedule 13G.

Entity  ITEM 3 Classification

Eight Roads GP  FI
Eight Roads Holdings Limited  FI


Pandanus Partners, L.P. ("Pandanus") owns shares of FIL Limited ("FIL") voting
stock. While the percentage of total voting power represented by these shares
of FIL voting stock may fluctuate as a result of changes in the total number
of shares of FIL voting stock outstanding from time to time, it normally
represents more than 25% and less than 48.5% of the total votes which may be
cast by all holders of FIL voting stock. Pandanus Associates, Inc. ("PAI")
acts as general partner of Pandanus. Pandanus is owned by trusts for the
benefit of members of the Johnson family, including FIL's Chairman Abigail P.
Johnson, but disclaims that any such member is a beneficial owner of the
securities reported on this Schedule 13G.

This filing reflects the securities beneficially owned, or that may be deemed
to be beneficially owned, by FIL, certain of its subsidiaries and affiliates,
and other companies (collectively, the "FIL Reporters"). This filing does not
reflect securities, if any, beneficially owned by certain other companies
whose beneficial ownership of securities is disaggregated from that of the FIL
Reporters in accordance with Securities and Exchange Commission Release No.
34-39538 (January 12, 1998).


RULE 13d-1(k)(1) AGREEMENT

The undersigned persons, on February 9, 2023, agree and consent to the joint
filing on their behalf of this Schedule 13G in connection with their
beneficial ownership of the COMMON STOCK of STRUCTURE THERAPEUTICS INC at
February 7, 2023.

FIL Limited

By /s/ Stephanie J. Brown
Stephanie J. Brown
Duly authorized under Power of Attorney effective as of December 19, 2022, by
and on behalf of FIL Limited and its direct and indirect subsidiaries*

Pandanus Partners, L.P.

By /s/ Stephanie J. Brown
Stephanie J. Brown
Duly authorized under Power of Attorney effective as of December 19, 2022, by
Pandanus Associates, Inc. on behalf of Pandanus Partners, L.P.*

Pandanus Associates, Inc.

By /s/ Stephanie J. Brown
Stephanie J. Brown
Duly authorized under Power of Attorney effective as of December 19, 2022, by
and on behalf of Pandanus Associates, Inc.*


* This power of attorney is incorporated herein by reference to Exhibit 24 to
the Schedule 13G filed by FIL Limited on January 31, 2023, accession number:
0000318989-23-000005.