Insider filing report for Changes in Beneficial Ownership
- Schedule 13G & 13D forms are used to report a party's ownership of stock which exceeds 5% of a company's total stock issue.
- Schedule 13G is a shorter version of Schedule 13D with fewer reporting requirements.
"Insiders might sell their shares for any number of reasons, but they buy them for only one: they think the price will rise"
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- Peter Lynch
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SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549 |
SCHEDULE 13G
|
UNDER THE SECURITIES EXCHANGE ACT OF 1934
|
(Amendment No. 6)*
|
Alector, Inc. (Name of Issuer) |
Common Stock, $0.0001 par value per share (Title of Class of Securities) |
014442107 (CUSIP Number) |
09/30/2025 (Date of Event Which Requires Filing of this Statement) |
| Check the appropriate box to designate the rule pursuant to which this Schedule is filed: |
 Rule 13d-1(b)
|
| Rule 13d-1(c)
|
 Rule 13d-1(d)
|
SCHEDULE 13G
|
| CUSIP No. | 014442107 |
| 1 | Names of Reporting Persons
Polaris Venture Partners VI, L.P. | ||||||||
| 2 | Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
| ||||||||
| 3 | Sec Use Only | ||||||||
| 4 | Citizenship or Place of Organization
DELAWARE
| ||||||||
| Number of Shares Beneficially Owned by Each Reporting Person With: |
| ||||||||
| 9 | Aggregate Amount Beneficially Owned by Each Reporting Person
498,468.00 | ||||||||
| 10 | Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
| ||||||||
| 11 | Percent of class represented by amount in row (9)
0.5 % | ||||||||
| 12 | Type of Reporting Person (See Instructions)
PN |
Comment for Type of Reporting Person: All shares are held of record by PVP VI (as defined in Item 2(a) of the Original Schedule 13G (as defined below)). PVM VI (as defined in Item 2(a) of the Original Schedule 13G), the general partner of PVP VI, may be deemed to have voting, investment and dispositive power with respect to these securities. David Barrett, Brian Chee, Jonathan A. Flint, Terrance G. McGuire, Amir Nashat, and Bryce Youngren are the managing members of PVM VI and may each be deemed to share voting, investment and dispositive power with respect to these securities. The percentage in Row 11 is based on 109,151,472 shares of the Issuer's common stock ("Common Stock") outstanding as of October 31, 2025, as set forth in the Issuer's quarterly report on Form 10-Q for the quarter ended September 30, 2025, filed with the United States Securities and Exchange Commission (the "Commission") on November 6, 2025 (the "Form 10-Q").
SCHEDULE 13G
|
| CUSIP No. | 014442107 |
| 1 | Names of Reporting Persons
Polaris Venture Partners Founders' Fund VI, L.P. | ||||||||
| 2 | Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
| ||||||||
| 3 | Sec Use Only | ||||||||
| 4 | Citizenship or Place of Organization
DELAWARE
| ||||||||
| Number of Shares Beneficially Owned by Each Reporting Person With: |
| ||||||||
| 9 | Aggregate Amount Beneficially Owned by Each Reporting Person
378,403.00 | ||||||||
| 10 | Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
| ||||||||
| 11 | Percent of class represented by amount in row (9)
0.3 % | ||||||||
| 12 | Type of Reporting Person (See Instructions)
PN |
Comment for Type of Reporting Person: All shares are held of record by PVPFF VI (as defined in Item 2(a) of the Original Schedule 13G). PVM VI, the general partner of PVPFF VI, may be deemed to have voting, investment and dispositive power with respect to these securities. David Barrett, Brian Chee, Jonathan A. Flint, Terrance G. McGuire, Amir Nashat, and Bryce Youngren are the managing members of PVM VI and may each be deemed to share voting, investment and dispositive power with respect to these securities. The percentage in Row 11 is based on 109,151,472 shares of Common Stock outstanding as of October 31, 2025, as set forth in the Form 10-Q.
SCHEDULE 13G
|
| CUSIP No. | 014442107 |
| 1 | Names of Reporting Persons
Polaris Venture Partners VI (AIV), L.P. | ||||||||
| 2 | Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
| ||||||||
| 3 | Sec Use Only | ||||||||
| 4 | Citizenship or Place of Organization
DELAWARE
| ||||||||
| Number of Shares Beneficially Owned by Each Reporting Person With: |
| ||||||||
| 9 | Aggregate Amount Beneficially Owned by Each Reporting Person
4,797,563.00 | ||||||||
| 10 | Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
| ||||||||
| 11 | Percent of class represented by amount in row (9)
4.4 % | ||||||||
| 12 | Type of Reporting Person (See Instructions)
PN |
Comment for Type of Reporting Person: All shares are held of record by PVP VI (AIV) (as defined in Item 2(a) of the Original Schedule 13G). PVM VI, the general partner of PVP VI (AIV), may be deemed to have voting, investment and dispositive power with respect to these securities. David Barrett, Brian Chee, Jonathan A. Flint, Terrance G. McGuire, Amir Nashat, and Bryce Youngren are the managing members of PVM VI and may each be deemed to share voting, investment and dispositive power with respect to these securities. The percentage in Row 11 is based on 109,151,472 shares of Common Stock outstanding as of October 31, 2025, as set forth in the Form 10-Q.
SCHEDULE 13G
|
| CUSIP No. | 014442107 |
| 1 | Names of Reporting Persons
Polaris Venture Partners VI (AIV-B), L.P. | ||||||||
| 2 | Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
| ||||||||
| 3 | Sec Use Only | ||||||||
| 4 | Citizenship or Place of Organization
DELAWARE
| ||||||||
| Number of Shares Beneficially Owned by Each Reporting Person With: |
| ||||||||
| 9 | Aggregate Amount Beneficially Owned by Each Reporting Person
1,179,383.00 | ||||||||
| 10 | Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
| ||||||||
| 11 | Percent of class represented by amount in row (9)
1.1 % | ||||||||
| 12 | Type of Reporting Person (See Instructions)
PN |
Comment for Type of Reporting Person: All shares are held of record by PVP VI (AIV-B) (as defined in Item 2(a) of the Original Schedule 13G). PVM VI, the general partner of PVP VI (AIV-B), may be deemed to have voting, investment and dispositive power with respect to these securities. David Barrett, Brian Chee, Jonathan A. Flint, Terrance G. McGuire, Amir Nashat, and Bryce Youngren are the managing members of PVM VI and may each be deemed to share voting, investment and dispositive power with respect to these securities. Based on 109,151,472 shares of Common Stock outstanding as of October 31, 2025, as set forth in the Form 10-Q.
SCHEDULE 13G
|
| CUSIP No. | 014442107 |
| 1 | Names of Reporting Persons
Polaris Venture Management Co VI, L.L.C. | ||||||||
| 2 | Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
| ||||||||
| 3 | Sec Use Only | ||||||||
| 4 | Citizenship or Place of Organization
DELAWARE
| ||||||||
| Number of Shares Beneficially Owned by Each Reporting Person With: |
| ||||||||
| 9 | Aggregate Amount Beneficially Owned by Each Reporting Person
6,853,817.00 | ||||||||
| 10 | Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
| ||||||||
| 11 | Percent of class represented by amount in row (9)
6.3 % | ||||||||
| 12 | Type of Reporting Person (See Instructions)
OO |
Comment for Type of Reporting Person: The shares reported in Rows 6 and 8 consist of (i) 498,468 shares held of record by PVP VI, (ii) 378,403 shares held of record by PVPFF VI, (iii) 4,797,563 shares held of record by PVP VI (AIV) and (iv) 1,179,383 shares held of record by PVP VI (AIV-B). PVM VI, the general partner of each of PVP VI, PVPFF VI, PVP VI (AIV) and PVP VI (AIV-B), may be deemed to have voting, investment and dispositive power with respect to these securities. David Barrett, Brian Chee, Jonathan A. Flint, Terrance G. McGuire, Amir Nashat, and Bryce Youngren are the managing members of PVM VI and may each be deemed to share voting, investment and dispositive power with respect to these securities. The percentage in Row 11 is based on 109,151,472 shares of Common Stock outstanding as of October 31, 2025, as set forth in the Form 10-Q.
SCHEDULE 13G
|
| CUSIP No. | 014442107 |
| 1 | Names of Reporting Persons
David Barrett | ||||||||
| 2 | Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
| ||||||||
| 3 | Sec Use Only | ||||||||
| 4 | Citizenship or Place of Organization
UNITED STATES
| ||||||||
| Number of Shares Beneficially Owned by Each Reporting Person With: |
| ||||||||
| 9 | Aggregate Amount Beneficially Owned by Each Reporting Person
6,880,071.00 | ||||||||
| 10 | Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
| ||||||||
| 11 | Percent of class represented by amount in row (9)
6.3 % | ||||||||
| 12 | Type of Reporting Person (See Instructions)
IN |
Comment for Type of Reporting Person: The shares reported in Rows 5 and 7 are held directly by David Barrett. The shares reported in Rows 6 and 8 consist of (i) 498,468 shares held of record by PVP VI, (ii) 378,403 shares held of record by PVPFF VI, (iii) 4,797,563 shares held of record by PVP VI (AIV) and (iv) 1,179,383 shares held of record by PVP VI (AIV-B). PVM VI, the general partner of each of PVP VI, PVPFF VI, PVP VI (AIV) and PVP VI (AIV-B), may be deemed to have voting, investment and dispositive power with respect to these securities. David Barrett, Brian Chee, Jonathan A. Flint, Terrance G. McGuire, Amir Nashat, and Bryce Youngren are the managing members of PVM VI and may each be deemed to share voting, investment and dispositive power with respect to these securities. The percentage in Row 11 is based on 109,151,472 shares of Common Stock outstanding as of October 31, 2025, as set forth in the Form 10-Q.
SCHEDULE 13G
|
| CUSIP No. | 014442107 |
| 1 | Names of Reporting Persons
Brian Chee | ||||||||
| 2 | Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
| ||||||||
| 3 | Sec Use Only | ||||||||
| 4 | Citizenship or Place of Organization
UNITED STATES
| ||||||||
| Number of Shares Beneficially Owned by Each Reporting Person With: |
| ||||||||
| 9 | Aggregate Amount Beneficially Owned by Each Reporting Person
6,880,084.00 | ||||||||
| 10 | Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
| ||||||||
| 11 | Percent of class represented by amount in row (9)
6.3 % | ||||||||
| 12 | Type of Reporting Person (See Instructions)
IN |
Comment for Type of Reporting Person: The shares reported in Rows 5 and 7 are held directly by Brian Chee. The shares reported in Rows 6 and 8 consist of (i) 498,468 shares held of record by PVP VI, (ii) 378,403 shares held of record by PVPFF VI (iii) 4,797,563 shares held of record by PVP VI (AIV) and (iv) 1,179,383 shares held of record by PVP VI (AIV-B). PVM VI, the general partner of each of PVP VI, PVPFF VI, PVP VI (AIV) and PVP VI (AIV-B), may be deemed to have voting, investment and dispositive power with respect to these securities. David Barrett, Brian Chee, Jonathan A. Flint, Terrance G. McGuire, Amir Nashat, and Bryce Youngren are the managing members of PVM VI and may each be deemed to share voting, investment and dispositive power with respect to these securities. The percentage in Row 11 is based on 109,151,472 shares of Common Stock outstanding as of October 31, 2025, as set forth in the Form 10-Q.
SCHEDULE 13G
|
| CUSIP No. | 014442107 |
| 1 | Names of Reporting Persons
Jonathan A. Flint | ||||||||
| 2 | Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
| ||||||||
| 3 | Sec Use Only | ||||||||
| 4 | Citizenship or Place of Organization
UNITED STATES
| ||||||||
| Number of Shares Beneficially Owned by Each Reporting Person With: |
| ||||||||
| 9 | Aggregate Amount Beneficially Owned by Each Reporting Person
6,892,942.00 | ||||||||
| 10 | Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
| ||||||||
| 11 | Percent of class represented by amount in row (9)
6.3 % | ||||||||
| 12 | Type of Reporting Person (See Instructions)
IN |
Comment for Type of Reporting Person: The shares reported in Rows 5 and 7 are held directly by Jonathan A. Flint. The shares reported in Rows 6 and 8 consist of (i) 498,468 shares held of record by PVP VI, (ii) 378,403 shares held of record by PVPFF VI (iii) 4,797,563 shares held of record by PVP VI (AIV) and (iv) 1,179,383 shares held of record by PVP VI (AIV-B). PVM VI, the general partner of each of PVP VI, PVPFF VI, PVP VI (AIV) and PVP VI (AIV-B), may be deemed to have voting, investment and dispositive power with respect to these securities. David Barrett, Brian Chee, Jonathan A. Flint, Terrance G. McGuire, Amir Nashat, and Bryce Youngren are the managing members of PVM VI and may each be deemed to share voting, investment and dispositive power with respect to these securities. The percentage in Row 11 is based on 109,151,472 shares of Common Stock outstanding as of October 31, 2025, as set forth in the Form 10-Q.
SCHEDULE 13G
|
| CUSIP No. | 014442107 |
| 1 | Names of Reporting Persons
Terrance G. McGuire | ||||||||
| 2 | Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
| ||||||||
| 3 | Sec Use Only | ||||||||
| 4 | Citizenship or Place of Organization
UNITED STATES
| ||||||||
| Number of Shares Beneficially Owned by Each Reporting Person With: |
| ||||||||
| 9 | Aggregate Amount Beneficially Owned by Each Reporting Person
7,095,251.00 | ||||||||
| 10 | Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
| ||||||||
| 11 | Percent of class represented by amount in row (9)
6.5 % | ||||||||
| 12 | Type of Reporting Person (See Instructions)
IN |
Comment for Type of Reporting Person: The shares reported in Rows 5 and 7 consist of (i) 70,719 shares held directly by Terrance G. McGuire, (ii) 144,465 shares held by McGuire Family Trust, and (iii) 26,250 shares consist of restricted stock units that have been granted to Terrance G. McGuire in his capacity as a former director of the Issuer. Terrance G. McGuire is the donor of the McGuire Family Trust and may be deemed to share voting, investment and dispositive power with respect to the shares held by the McGuire Family Trust. The shares reported in Rows 6 and 8 consist of (i) 498,468 shares held of record by PVP VI, (ii) 378,403 shares held of record by PVPFF VI (iii) 4,797,563 shares held of record by PVP VI (AIV) and (iv) 1,179,383 shares held of record by PVP VI (AIV-B). PVM VI, the general partner of each of PVP VI, PVPFF VI, PVP VI (AIV) and PVP VI (AIV-B), may be deemed to have voting, investment and dispositive power with respect to these securities. David Barrett, Brian Chee, Jonathan A. Flint, Terrance G. McGuire, Amir Nashat, and Bryce Youngren are the managing members of PVM VI and may each be deemed to share voting, investment and dispositive power with respect to these securities. The percentage in Row 11 is based on 109,177,722 shares of Common Stock, calculated as follows: (i) 26,250 shares that represent restricted stock units that have been granted to Mr. McGuire in his capacity as a former director of the Issuer plus (ii) 109,151,472 shares of Common Stock outstanding as of October 31, 2025, as set forth in the Form 10-Q.
SCHEDULE 13G
|
| CUSIP No. | 014442107 |
| 1 | Names of Reporting Persons
Amir Nashat | ||||||||
| 2 | Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
| ||||||||
| 3 | Sec Use Only | ||||||||
| 4 | Citizenship or Place of Organization
UNITED STATES
| ||||||||
| Number of Shares Beneficially Owned by Each Reporting Person With: |
| ||||||||
| 9 | Aggregate Amount Beneficially Owned by Each Reporting Person
6,932,617.00 | ||||||||
| 10 | Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
| ||||||||
| 11 | Percent of class represented by amount in row (9)
6.4 % | ||||||||
| 12 | Type of Reporting Person (See Instructions)
IN |
Comment for Type of Reporting Person: The shares reported in Rows 5 and 7 are held directly by Amir Nashat. The shares reported in Rows 6 and 8 consist of (i) 498,468 shares held of record by PVP VI, (ii) 378,403 shares held of record by PVPFF VI, (iii) 4,797,563 shares held of record by PVP VI (AIV) and (iv) 1,179,383 shares held of record by PVP VI (AIV-B). PVM VI, the general partner of each of PVP VI, PVPFF VI, PVP VI (AIV) and PVP VI (AIV-B), may be deemed to have voting, investment and dispositive power with respect to these securities. David Barrett, Brian Chee, Jonathan A. Flint, Terrance G. McGuire, Amir Nashat, and Bryce Youngren are the managing members of PVM VI and may each be deemed to share voting, investment and dispositive power with respect to these securities. The percentage in Row 11 is based on 109,151,472 shares of Common Stock outstanding as of October 31, 2025, as set forth in the Form 10-Q.
SCHEDULE 13G
|
| CUSIP No. | 014442107 |
| 1 | Names of Reporting Persons
Bryce Youngren | ||||||||
| 2 | Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
| ||||||||
| 3 | Sec Use Only | ||||||||
| 4 | Citizenship or Place of Organization
UNITED STATES
| ||||||||
| Number of Shares Beneficially Owned by Each Reporting Person With: |
| ||||||||
| 9 | Aggregate Amount Beneficially Owned by Each Reporting Person
6,945,149.00 | ||||||||
| 10 | Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
| ||||||||
| 11 | Percent of class represented by amount in row (9)
6.4 % | ||||||||
| 12 | Type of Reporting Person (See Instructions)
IN |
Comment for Type of Reporting Person: The shares reported in Rows 5 and 7 are held directly by Bryce Youngren. The shares reported in Rows 6 and 8 consist of (i) 498,468 shares held of record by PVP VI, (ii) 378,403 shares held of record by PVPFF VI (iii) 4,797,563 shares held of record by PVP VI (AIV) and (iv) 1,179,383 shares held of record by PVP VI (AIV-B). PVM VI, the general partner of each of PVP VI, PVPFF VI, PVP VI (AIV) and PVP VI (AIV-B), may be deemed to have voting, investment and dispositive power with respect to these securities. David Barrett, Brian Chee, Jonathan A. Flint, Terrance G. McGuire, Amir Nashat, and Bryce Youngren are the managing members of PVM VI and may each be deemed to share voting, investment and dispositive power with respect to these securities. The percentage in Row 11 is based on 109,151,472 shares of Common Stock outstanding as of October 31, 2025, as set forth in the Form 10-Q.
SCHEDULE 13G
|
| Item 1. | |
| (a) | Name of issuer:
Alector, Inc. |
| (b) | Address of issuer's principal executive offices:
131 OYSTER POINT BLVD., SUITE 600, SOUTH SAN FRANCISCO, CA, 94080 |
| Item 2. | |
| (a) | Name of person filing:
This Amendment No. 6 (this "Amendment") amends and supplements the Schedule 13G initially filed with the Commission on February 12, 2020, as amended by Amendment No. 1 filed with the Commission on February 12, 2021, Amendment No. 2 filed with the Commission on February 11, 2022, Amendment No. 3 filed with the Commission on February 7, 2023, Amendment No. 4 filed with the Commission on February 9, 2024 and Amendment No. 5 filed with the Commission on November 12, 2024 (collectively, the "Original Schedule 13G"). Only those items that are hereby reported are amended; all other items reported in the Original Schedule 13G remain unchanged. Information given in response to each item shall be deemed incorporated by reference in all other items, as applicable. Capitalized terms not defined in this Amendment have the meanings ascribed to them in the Original Schedule 13G. The following information in Item 4 with respect to the ownership of the Issuer's Common Stock by the Reporting Persons filing this Amendment No. 6 is provided as of November 6, 2025. Each of the Reporting Persons disclaims beneficial ownership of the shares of Common Stock reported in this Amendment No. 6, except for the shares, if any, such Reporting Person holds of record and to the extent of such Reporting Person's pecuniary interest therein. |
| (b) | Address or principal business office or, if none, residence:
|
| (c) | Citizenship:
|
| (d) | Title of class of securities:
Common Stock, $0.0001 par value per share |
| (e) | CUSIP No.:
014442107 |
| Item 4. | Ownership |
| (a) | Amount beneficially owned:
See Row 9 of cover page for each Reporting Person and the corresponding footnotes. |
| (b) | Percent of class:
See Row 11 of cover page for each Reporting Person and the corresponding footnotes. %
|
| (c) | Number of shares as to which the person has:
|
| (i) Sole power to vote or to direct the vote:
See Row 5 of cover page for each Reporting Person and the corresponding footnotes. | |
| (ii) Shared power to vote or to direct the vote:
See Row 6 of cover page for each Reporting Person and the corresponding footnotes. | |
| (iii) Sole power to dispose or to direct the disposition of:
See Row 7 of cover page for each Reporting Person and the corresponding footnotes. | |
| (iv) Shared power to dispose or to direct the disposition of:
See Row 8 of cover page for each Reporting Person and the corresponding footnotes. |
| Item 10. | Certifications: |
| SIGNATURE | |
After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.
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Comments accompanying signature: This Schedule 13G was executed pursuant to a Power of Attorney. Note that copies of the applicable Power of Attorney are already on file with the appropriate agencies.