Sec Form 13G Filing - Palo Alto Investors LP filing for INSMED Inc (INSM) - 2022-02-14

Insider filing report for Changes in Beneficial Ownership

  • Schedule 13G & 13D forms are used to report a party's ownership of stock which exceeds 5% of a company's total stock issue.
  • Schedule 13G is a shorter version of Schedule 13D with fewer reporting requirements.
"Insiders might sell their shares for any number of reasons, but they buy them for only one: they think the price will rise"
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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
TO RULE 13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED
PURSUANT TO RULE 13d-2(b)

(AMENDMENT NO. 7)*

Insmed Inc.
(Name of Issuer)

Common Stock
(Title of Class of Securities)

457669307
(CUSIP Number)

December 31, 2021
(Date of Event which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
 is filed:

       [ X ] Rule 13d-1(b)
       [     ] Rule 13d-1(c)
       [     ] Rule 13d-1(d)

* The remainder of this cover page shall be filled out for a reporting
 person's initial filing on this form with respect to the subject
 class of securities, and for any subsequent amendment containing
 information which would alter disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be
 deemed to be "filed" for the purpose of Section 18 of the Securities
 Exchange Act of 1934 ("Act") or otherwise subject to the liabilities
 of that section of the Act but shall be subject to all other provisions
 of the Act (however, see the Notes).


CUSIP No. 457669307

13G

Page 2 of 10 Pages

1.
NAMES OF REPORTING PERSONS OR
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

Patrick Lee, MD

2.
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(see instructions)

(a) [    ]
(b) [ x ]
3.
SEC USE ONLY


4.
CITIZENSHIP OR PLACE OF ORGANIZATION
USA


NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
5.
SOLE VOTING POWER

 0

6.
SHARED VOTING POWER

6,025,706

7.
SOLE DISPOSITIVE POWER

 0

8.
SHARED DISPOSITIVE POWER

 6,025,706

9.
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 6,025,706

10.
CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
(see instructions) [  ]


11.
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

  5.09%

12.
TYPE OF REPORTING PERSON (see instructions)

 IN, HC







CUSIP No. 457669307

13G

Page 3 of 10 Pages

1.
NAMES OF REPORTING PERSONS OR
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

Anthony Joonkyoo Yun, MD

2.
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(see instructions)

(a) [    ]
(b) [ x ]
3.
SEC USE ONLY


4.
CITIZENSHIP OR PLACE OF ORGANIZATION
 USA


NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
5.
SOLE VOTING POWER

 0

6.
SHARED VOTING POWER

6,025,706

7.
SOLE DISPOSITIVE POWER

 0

8.
SHARED DISPOSITIVE POWER

6,025,706

9.
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

6,025,706

10.
CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
(see instructions) [  ]


11.
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

5.09%

12.
TYPE OF REPORTING PERSON (see instructions)

 IN, HC









CUSIP No. 457669307

13G

Page 4 of 10 Pages

1.
NAMES OF REPORTING PERSONS OR
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

Palo Alto Investors LP

2.
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(see instructions)

(a) [    ]
(b) [ x ]
3.
SEC USE ONLY


4.
CITIZENSHIP OR PLACE OF ORGANIZATION
California


NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
5.
SOLE VOTING POWER

 0

6.
SHARED VOTING POWER

6,025,706

7.
SOLE DISPOSITIVE POWER

 0

8.
SHARED DISPOSITIVE POWER

 6,025,706

9.
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 6,025,706

10.
CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
(see instructions) [  ]


11.
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

  5.09%

12.
TYPE OF REPORTING PERSON (see instructions)

 OO, IA







CUSIP No. 457669307

13G

Page 5 of 10 Pages

1.
NAMES OF REPORTING PERSONS OR
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

PAI LLC

2.
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(see instructions)

(a) [    ]
(b) [ x ]
3.
SEC USE ONLY


4.
CITIZENSHIP OR PLACE OF ORGANIZATION
California


NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
5.
SOLE VOTING POWER

 0

6.
SHARED VOTING POWER

6,025,706

7.
SOLE DISPOSITIVE POWER

 0

8.
SHARED DISPOSITIVE POWER

 6,025,706

9.
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

6,025,706

10.
CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
(see instructions) [  ]


11.
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

 5.09%

12.
TYPE OF REPORTING PERSON (see instructions)

 OO, IA







CUSIP No. 457669307

13G

Page 6 of 10 Pages

Item 1.

(a)
Name of Issuer


Insmed Inc.




(b)
Address of Issuer's Principal Executive Offices

700 US Highway 202/206, Bridgewater, NJ, 08807


Item 2.

(a)
Name of Person Filing

Palo Alto Investors LP ("PAI"), PAI LLC ("PAI GP"),Patrick Lee, MD
Anthony Joonkyoo Yun, MD

(collectively, the "Filers").




(b)
The address of the principal place of the Filers is located at:

470 University Avenue, Palo Alto, CA 94301






(c)
 For citizenship of Filers, see Item 4 of the cover sheet for each Filer.





(d)
Title of Class of Securities

Common Stock




(e)
CUSIP Number

457669307

Item 3. If this statement is filed pursuant to 240.13d-1(b)
 or 240.13d-2(b) or (c), check whether the person filing is a:


(a)
[  ]
Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o).





(b)
[  ]
Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).





(c)
[  ]
Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c).







(d)
[  ]
Investment company registered under section 8 of the
Investment Company Act of 1940 (15 U.S.C. 80a-8).


(e)
[x]
An investment adviser in accordance with 240.13d-1(b)(1)(ii)(E); (as to PAI)











(f)
[  ]
An employee benefit plan or endowment fund in
 accordance with 240.13d-1(b)(1)(ii)(F);


CUSIP No. 457669307

13G

Page 7 of 10 Pages








(g)
[x]
A parent holding company or control person in accordance
 with 240.13d-1(b)(1)(ii)(G); (as to Dr. Lee and Dr. Yun).





(h)
[  ]
A savings associations as defined in Section 3(b) of the
 Federal Deposit Insurance Act (12 U.S.C. 1813);





(i)
[  ]
A church plan that is excluded from the definition of an investment company
 under section 3(c)(14) of the Investment Company Act
 of 1940 (15 U.S.C. 80a-3);





(j)
[  ]
Group, in accordance with 240.13d-1(b)(1)(ii)(J).



CUSIP No. 457669307

13G

Page 8 of 10 Pages

Item 4. Ownership.

See Items 5-9 and 11 of the cover page for each Filer.

Item 5. Ownership of Five Percent or Less of a Class.

N/A

Item 6. Ownership of More than Five Percent on Behalf of Another Person.

PAI is a registered investment adviser and investment adviser
 of investment limited partnerships, and is the investment adviser
 to other investment funds. PAI GP is the general partner of investment
 limited partnerships. PAI's clients have the right to receive or the
 power to direct the receipt of dividends from, or
 the proceeds from the sale of, the Stock.

Item 7. Identification and Classification of the Subsidiary Which
 Acquired the Security Being Reported on By the Parent Holding Company.

N/A

Item 8. Identification and Classification of Members of the Group.

Dr. Lee and Dr. Yun co-manage PAI. The Filers are filing this
 Schedule 13G jointly, but not as members of a group, and each of them
 expressly disclaims membership in a group. Each Filer disclaims
 beneficial ownership of the Stock except to the extent of
 that Filer's pecuniary interest therein.


Item 9. Notice of Dissolution of Group.

N/A




CUSIP No. 457669307

13G

Page 9 of 10 Pages

Item 10. Certification.

 By signing below I certify that, to the best of my knowledge and belief,
 the securities referred to above were not acquired and are not held for
 the purpose of or with the effect of changing or influencing the control
 of the issuer of the securities and were not acquired and are not held
 in connection with or as a participant in any transaction having that
 purpose or effect.

Exhibits, Exhibit A Joint Filing Agreement.


SIGNATURE


After reasonable inquiry and to the best of my knowledge and belief,
 I certify that the information set forth in this statement is true,
 complete and correct., Dated: February 14, 2022



PALO ALTO INVESTORS LP

By: /s/ Angela Nguyen-Dinh, Chief Compliance Officer, PAI LLC, By: /s/
 Patrick Lee, MD, /s/ Patrick Lee, MD, /s/ Anthony Joonkyoo Yun, MD



CUSIP No. 457669307

13G

Page 10 of 10 Pages

EXHIBIT A
AGREEMENT REGARDING JOINT FILING
OF STATEMENT ON SCHEDULE 13D OR 13G, The undersigned agree to file
 jointly with the Securities and Exchange Commission
 (the "SEC") any and all statements on Schedule 13D or Schedule 13G
 (and any amendments or supplements thereto) required under section 13(d)
 of the Securities Exchange Act of 1934, as amended, in connection with
purchases and sales by the undersigned of the securities of any issuer
 until such time as the undersigned file with the SEC a statement terminating
 this Agreement Regarding Joint Filing of Statement on Schedule 13D or 13G.
 For that purpose, the undersigned hereby constitute and appoint
 Palo Alto Investors, LP, a California limited partnership, as their
 true and lawful agent and attorney-in-fact, with full power and authority
 for and on behalf of the undersigned to prepare or cause to be prepared,
 sign, file with the SEC and furnish to any other person all certificates,
 instruments, agreements and documents necessary to comply with section 13(d)
 and section 16(a) of the Securities Exchange Act of 1934, as amended, in
 connection with said purchases and sales, and to do and perform every act
necessary and proper to be done incident to the exercise of the foregoing
 power, as fully as the undersigned might or could do if personally present,
 until such time as the undersigned file with the SEC a statement terminating
 this Agreement Regarding Joint Filing of Statement on Schedule 13D or 13G.
Dated: February 14, 2022, PALO ALTO INVESTORS LP

By: /s/ Angela Nguyen-Dinh, Chief Compliance Officer, PAI LLC. By: /s/
 Patrick Lee, MD, /s/ Patrick Lee, MD, /s/ Anthony Joonkyoo Yun, MD