Sec Form 13D Filing - ALTA PARTNERS filing for AVADEL PHARMACEUTICALS PLC (AVDL) - 2003-10-09

Insider filing report for Changes in Beneficial Ownership

  • Schedule 13G & 13D forms are used to report a party's ownership of stock which exceeds 5% of a company's total stock issue.
  • Schedule 13G is a shorter version of Schedule 13D with fewer reporting requirements.
"Insiders might sell their shares for any number of reasons, but they buy them for only one: they think the price will rise"
- Peter Lynch
What is insider trading>>

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                  SCHEDULE 13D
                                 Amendment No. 5

                    Under the Securities Exchange Act of 1934

                            Flamel Technologies S.A.
                           --------------------------
                                (Name of Issuer)

                                Ordinary Shares
                           --------------------------
                         (Title of Class of Securities)

                                   338488 10 9
                           --------------------------
                                 (CUSIP Number)

                                  Hilary Strain
                       One Embarcadero Center, Suite 4050
                             San Francisco, CA 94111
                                 (415) 362-4022
                           --------------------------
           (Name, Address and Telephone Number of Person Authorized to
                       Receive Notices and Communications)

                                October 2, 2003
                           --------------------------
             (Date of Event which Requires Filing of this Statement)

         If the filing person has  previously  filed a statement on Schedule 13G
to report the  acquisition  which is the subject of this  Schedule  13D,  and is
filing this schedule because of Rule 13d-1(b)(3) or (4), check the following box
[ ].

         Check the following box if a fee is being paid with this statement [ ].
(A fee  is not  required  only  if the  reporting  person:  (1)  has a  previous
statement on file  reporting  beneficial  ownership of more than five percent of
the class of  securities  described  in Item 1; and (2) has  filed no  amendment
subsequent  thereto  reporting  beneficial  ownership of five percent or less of
such class. (See Rule 13d-7).

         Note: Six copies of this statement,  including all exhibits,  should be
filed with the  Commission.  See Rule  13d-1(a) for other parties to whom copies
are to be sent.

         * The  remainder of this cover page shall be filled out for a reporting
person's  initial  filing on this  form with  respect  to the  subject  class of
securities,  and for any subsequent amendment containing information which would
alter the disclosures provided in a prior cover page.

         The information  required on the remainder of this cover page shall not
be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934,  as  amended  (the  "Exchange  Act") or  otherwise  subject  to the
liabilities  of that  section  of the  Exchange  Act but shall be subject to all
other provisions of the Exchange Act.

                        (Continued on following page(s))

                               Page 1 of 16 Pages


CUSIP No. 0338488 10 9                    13D                 Page 2 of 16 Pages

- --------------------------------------------------------------------------------
  (1) Names of  Reporting  Persons.  SS or I.R.S.  Identification  Nos. of Above
      Persons

      Alta Partners
- --------------------------------------------------------------------------------
  (2) Check The Appropriate Box If A Member Of A Group           (a):
                                                                 (b) X

- --------------------------------------------------------------------------------
  (3) SEC Use Only

- --------------------------------------------------------------------------------
  (4) Source Of Funds*

      WC
- --------------------------------------------------------------------------------
  (5) Check Box If Disclosure Of Legal Proceedings Is Required Pursuant To Items
      2(d) Or 2(e):

- --------------------------------------------------------------------------------
  (6) Citizenship Or Place Of Organization

      California
- --------------------------------------------------------------------------------
Number Of Shares                            (7)  Sole Voting Power        -0-
Beneficially Owned
By Each Reporting
Person With                                 (8)  Shared Voting Power      -0-


                                            (9)  Sole Dispositive Power   -0-


                                            (10) Shared Dispositive Power -0-


  (11)   Aggregate Amount Beneficially Owned By Each Reporting Person

                  -0-  Exit Filing
- --------------------------------------------------------------------------------
  (12)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

- --------------------------------------------------------------------------------
  (13)   Percent Of Class Represented By Amount In Row (11)

                  0%   Exit Filing
- --------------------------------------------------------------------------------
  (14)   Type Of Reporting Person

                  CO
- --------------------------------------------------------------------------------

                      *SEE INSTRUCTION BEFORE FILLING OUT!


CUSIP No. 0338488 10 9                    13D                 Page 3 of 16 Pages

- --------------------------------------------------------------------------------
  (1) Names of  Reporting  Persons.  SS or I.R.S.  Identification  Nos. of Above
      Persons

      Alta BioPharma Partners, L.P.
- --------------------------------------------------------------------------------
  (2) Check The Appropriate Box If A Member Of A Group           (a):
                                                                 (b) X

- --------------------------------------------------------------------------------
  (3) SEC Use Only

- --------------------------------------------------------------------------------
  (4) Source Of Funds*

      WC
- --------------------------------------------------------------------------------
  (5) Check Box If Disclosure Of Legal Proceedings Is Required Pursuant To Items
      2(d) Or 2(e):

- --------------------------------------------------------------------------------
  (6) Citizenship Or Place Of Organization

      Delaware
- --------------------------------------------------------------------------------
Number Of Shares                            (7)  Sole Voting Power        -0-
Beneficially Owned
By Each Reporting
Person With                                 (8)  Shared Voting Power      -0-


                                            (9)  Sole Dispositive Power   -0-


                                            (10) Shared Dispositive Power -0-


  (11)   Aggregate Amount Beneficially Owned By Each Reporting Person

                  -0-  Exit Filing
- --------------------------------------------------------------------------------
  (12)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

- --------------------------------------------------------------------------------
  (13)   Percent Of Class Represented By Amount In Row (11)

                  0%   Exit Filing
- --------------------------------------------------------------------------------
  (14)   Type Of Reporting Person

                  PN
- --------------------------------------------------------------------------------

                      *SEE INSTRUCTION BEFORE FILLING OUT!


CUSIP No. 0338488 10 9                    13D                 Page 4 of 16 Pages

- --------------------------------------------------------------------------------
  (1) Names of  Reporting  Persons.  SS or I.R.S.  Identification  Nos. of Above
      Persons

      Alta Embarcadero BioPharma, LLC
- --------------------------------------------------------------------------------
  (2) Check The Appropriate Box If A Member Of A Group           (a):
                                                                 (b) X

- --------------------------------------------------------------------------------
  (3) SEC Use Only

- --------------------------------------------------------------------------------
  (4) Source Of Funds*

      WC
- --------------------------------------------------------------------------------
  (5) Check Box If Disclosure Of Legal Proceedings Is Required Pursuant To Items
      2(d) Or 2(e):

- --------------------------------------------------------------------------------
  (6) Citizenship Or Place Of Organization

      California
- --------------------------------------------------------------------------------
Number Of Shares                            (7)  Sole Voting Power        -0-
Beneficially Owned
By Each Reporting
Person With                                 (8)  Shared Voting Power      -0-


                                            (9)  Sole Dispositive Power   -0-


                                            (10) Shared Dispositive Power -0-


  (11)   Aggregate Amount Beneficially Owned By Each Reporting Person

                  -0-  Exit Filing
- --------------------------------------------------------------------------------
  (12)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

- --------------------------------------------------------------------------------
  (13)   Percent Of Class Represented By Amount In Row (11)

                  0%   Exit Filing
- --------------------------------------------------------------------------------
  (14)   Type Of Reporting Person

                  CO
- --------------------------------------------------------------------------------

                      *SEE INSTRUCTION BEFORE FILLING OUT!


CUSIP No. 0338488 10 9                    13D                 Page 5 of 16 Pages

- --------------------------------------------------------------------------------
  (1) Names of  Reporting  Persons.  SS or I.R.S.  Identification  Nos. of Above
      Persons

      Flamel Chase Partners (Alta Bio), LLC
- --------------------------------------------------------------------------------
  (2) Check The Appropriate Box If A Member Of A Group           (a):
                                                                 (b) X

- --------------------------------------------------------------------------------
  (3) SEC Use Only

- --------------------------------------------------------------------------------
  (4) Source Of Funds*

      WC
- --------------------------------------------------------------------------------
  (5) Check Box If Disclosure Of Legal Proceedings Is Required Pursuant To Items
      2(d) Or 2(e):

- --------------------------------------------------------------------------------
  (6) Citizenship Or Place Of Organization

      Delaware
- --------------------------------------------------------------------------------
Number Of Shares                            (7)  Sole Voting Power        -0-
Beneficially Owned
By Each Reporting
Person With                                 (8)  Shared Voting Power      -0-


                                            (9)  Sole Dispositive Power   -0-


                                            (10) Shared Dispositive Power -0-


  (11)   Aggregate Amount Beneficially Owned By Each Reporting Person

                  -0-  Exit Filing
- --------------------------------------------------------------------------------
  (12)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

- --------------------------------------------------------------------------------
  (13)   Percent Of Class Represented By Amount In Row (11)

                  0%   Exit Filing
- --------------------------------------------------------------------------------
  (14)   Type Of Reporting Person

                  CO
- --------------------------------------------------------------------------------

                      *SEE INSTRUCTION BEFORE FILLING OUT!


CUSIP No. 0338488 10 9                    13D                 Page 6 of 16 Pages

- --------------------------------------------------------------------------------
  (1) Names of  Reporting  Persons.  SS or I.R.S.  Identification  Nos. of Above
      Persons

      Alta BioPharma Management, LLC
- --------------------------------------------------------------------------------
  (2) Check The Appropriate Box If A Member Of A Group           (a):
                                                                 (b) X

- --------------------------------------------------------------------------------
  (3) SEC Use Only

- --------------------------------------------------------------------------------
  (4) Source Of Funds*

      WC
- --------------------------------------------------------------------------------
  (5) Check Box If Disclosure Of Legal Proceedings Is Required Pursuant To Items
      2(d) Or 2(e):

- --------------------------------------------------------------------------------
  (6) Citizenship Or Place Of Organization

      Delaware
- --------------------------------------------------------------------------------
Number Of Shares                            (7)  Sole Voting Power        -0-
Beneficially Owned
By Each Reporting
Person With                                 (8)  Shared Voting Power      -0-


                                            (9)  Sole Dispositive Power   -0-


                                            (10) Shared Dispositive Power -0-


  (11)   Aggregate Amount Beneficially Owned By Each Reporting Person

                  -0-  Exit Filing
- --------------------------------------------------------------------------------
  (12)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

- --------------------------------------------------------------------------------
  (13)   Percent Of Class Represented By Amount In Row (11)

                  0%   Exit Filing
- --------------------------------------------------------------------------------
  (14)   Type Of Reporting Person

                  CO
- --------------------------------------------------------------------------------

                      *SEE INSTRUCTION BEFORE FILLING OUT!


CUSIP No. 0338488 10 9                    13D                 Page 7 of 16 Pages

- --------------------------------------------------------------------------------
  (1) Names of  Reporting  Persons.  SS or I.R.S.  Identification  Nos. of Above
      Persons

      Alta/Chase BioPharma Management, LLC
- --------------------------------------------------------------------------------
  (2) Check The Appropriate Box If A Member Of A Group           (a):
                                                                 (b) X

- --------------------------------------------------------------------------------
  (3) SEC Use Only

- --------------------------------------------------------------------------------
  (4) Source Of Funds*

      WC
- --------------------------------------------------------------------------------
  (5) Check Box If Disclosure Of Legal Proceedings Is Required Pursuant To Items
      2(d) Or 2(e):

- --------------------------------------------------------------------------------
  (6) Citizenship Or Place Of Organization

      Delaware
- --------------------------------------------------------------------------------
Number Of Shares                            (7)  Sole Voting Power        -0-
Beneficially Owned
By Each Reporting
Person With                                 (8)  Shared Voting Power      -0-


                                            (9)  Sole Dispositive Power   -0-


                                            (10) Shared Dispositive Power -0-


  (11)   Aggregate Amount Beneficially Owned By Each Reporting Person

                  -0-  Exit Filing
- --------------------------------------------------------------------------------
  (12)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

- --------------------------------------------------------------------------------
  (13)   Percent Of Class Represented By Amount In Row (11)

                  0%   Exit Filing
- --------------------------------------------------------------------------------
  (14)   Type Of Reporting Person

                  CO
- --------------------------------------------------------------------------------

                      *SEE INSTRUCTION BEFORE F
ILLING OUT!


CUSIP No. 0338488 10 9                    13D                 Page 8 of 16 Pages

- --------------------------------------------------------------------------------
  (1) Names of  Reporting  Persons.  SS or I.R.S.  Identification  Nos. of Above
      Persons

      Jean Deleage
- --------------------------------------------------------------------------------
  (2) Check The Appropriate Box If A Member Of A Group           (a):
                                                                 (b) X

- --------------------------------------------------------------------------------
  (3) SEC Use Only

- --------------------------------------------------------------------------------
  (4) Source Of Funds*

      AF
- --------------------------------------------------------------------------------
  (5) Check Box If Disclosure Of Legal Proceedings Is Required Pursuant To Items
      2(d) Or 2(e):

- --------------------------------------------------------------------------------
  (6) Citizenship Or Place Of Organization

      U.S.A.
- --------------------------------------------------------------------------------
Number Of Shares                            (7)  Sole Voting Power         1
Beneficially Owned
By Each Reporting
Person With                                 (8)  Shared Voting Power      -0-
                                                                      Footnote 1

                                            (9)  Sole Dispositive Power    1


                                            (10) Shared Dispositive Power -0-
                                                                      Footnote 1

  (11)   Aggregate Amount Beneficially Owned By Each Reporting Person

                  1  Please see Footnote 1      Exit Filing
- --------------------------------------------------------------------------------
  (12)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

- --------------------------------------------------------------------------------
  (13)   Percent Of Class Represented By Amount In Row (11)

                  0%   Exit Filing
- --------------------------------------------------------------------------------
  (14)   Type Of Reporting Person

                  IN
- --------------------------------------------------------------------------------

                      *SEE INSTRUCTION BEFORE FILLING OUT!

        Footnote 7: Jean Deleage owns one share of Flamel Ordinary stock.


CUSIP No. 0338488 10 9                    13D                 Page 9 of 16 Pages

- --------------------------------------------------------------------------------
  (1) Names of  Reporting  Persons.  SS or I.R.S.  Identification  Nos. of Above
      Persons

      Garrett Gruener
- --------------------------------------------------------------------------------
  (2) Check The Appropriate Box If A Member Of A Group           (a):
                                                                 (b) X

- --------------------------------------------------------------------------------
  (3) SEC Use Only

- --------------------------------------------------------------------------------
  (4) Source Of Funds*

      AF
- --------------------------------------------------------------------------------
  (5) Check Box If Disclosure Of Legal Proceedings Is Required Pursuant To Items
      2(d) Or 2(e):

- --------------------------------------------------------------------------------
  (6) Citizenship Or Place Of Organization

      U.S.A.
- --------------------------------------------------------------------------------
Number Of Shares                            (7)  Sole Voting Power        -0-
Beneficially Owned
By Each Reporting
Person With                                 (8)  Shared Voting Power      -0-


                                            (9)  Sole Dispositive Power   -0-


                                            (10) Shared Dispositive Power -0-


  (11)   Aggregate Amount Beneficially Owned By Each Reporting Person

                  -0-  Exit Filing
- --------------------------------------------------------------------------------
  (12)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

- --------------------------------------------------------------------------------
  (13)   Percent Of Class Represented By Amount In Row (11)

                  0%   Exit Filing
- --------------------------------------------------------------------------------
  (14)   Type Of Reporting Person

                  IN
- --------------------------------------------------------------------------------

                      *SEE INSTRUCTION BEFORE FILLING OUT!


CUSIP No. 0338488 10 9                    13D                Page 10 of 16 Pages

- --------------------------------------------------------------------------------
  (1) Names of  Reporting  Persons.  SS or I.R.S.  Identification  Nos. of Above
      Persons

      Daniel Janney
- --------------------------------------------------------------------------------
  (2) Check The Appropriate Box If A Member Of A Group           (a):
                                                                 (b) X

- --------------------------------------------------------------------------------
  (3) SEC Use Only

- --------------------------------------------------------------------------------
  (4) Source Of Funds*

      AF
- --------------------------------------------------------------------------------
  (5) Check Box If Disclosure Of Legal Proceedings Is Required Pursuant To Items
      2(d) Or 2(e):

- --------------------------------------------------------------------------------
  (6) Citizenship Or Place Of Organization

      U.S.A.
- --------------------------------------------------------------------------------
Number Of Shares                            (7)  Sole Voting Power        -0-
Beneficially Owned
By Each Reporting
Person With                                 (8)  Shared Voting Power      -0-


                                            (9)  Sole Dispositive Power   -0-


                                            (10) Shared Dispositive Power -0-


  (11)   Aggregate Amount Beneficially Owned By Each Reporting Person

                  -0-  Exit Filing
- --------------------------------------------------------------------------------
  (12)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

- --------------------------------------------------------------------------------
  (13)   Percent Of Class Represented By Amount In Row (11)

                  0%   Exit Filing
- --------------------------------------------------------------------------------
  (14)   Type Of Reporting Person

                  IN
- --------------------------------------------------------------------------------

                      *SEE INSTRUCTION BEFORE FILLING OUT!


CUSIP No. 0338488 10 9                    13D                Page 11 of 16 Pages

- --------------------------------------------------------------------------------
  (1) Names of  Reporting  Persons.  SS or I.R.S.  Identification  Nos. of Above
      Persons

      Alix Marduel
- --------------------------------------------------------------------------------
  (2) Check The Appropriate Box If A Member Of A Group           (a):
                                                                 (b) X

- --------------------------------------------------------------------------------
  (3) SEC Use Only

- --------------------------------------------------------------------------------
  (4) Source Of Funds*

      AF
- --------------------------------------------------------------------------------
  (5) Check Box If Disclosure Of Legal Proceedings Is Required Pursuant To Items
      2(d) Or 2(e):

- --------------------------------------------------------------------------------
  (6) Citizenship Or Place Of Organization

      U.S.A.
- --------------------------------------------------------------------------------
Number Of Shares                            (7)  Sole Voting Power        -0-
Beneficially Owned
By Each Reporting
Person With                                 (8)  Shared Voting Power      -0-


                                            (9)  Sole Dispositive Power   -0-


                                            (10) Shared Dispositive Power -0-


  (11)   Aggregate Amount Beneficially Owned By Each Reporting Person

                  -0-  Exit Filing
- --------------------------------------------------------------------------------
  (12)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

- --------------------------------------------------------------------------------
  (13)   Percent Of Class Represented By Amount In Row (11)

                  0%   Exit Filing
- --------------------------------------------------------------------------------
  (14)   Type Of Reporting Person

                  IN
- --------------------------------------------------------------------------------

                      *SEE INSTRUCTION BEFORE FILLING OUT!


CUSIP No. 0338488 10 9                    13D                Page 12 of 16 Pages

- --------------------------------------------------------------------------------
  (1) Names of  Reporting  Persons.  SS or I.R.S.  Identification  Nos. of Above
      Persons

      Guy Nohra
- --------------------------------------------------------------------------------
  (2) Check The Appropriate Box If A Member Of A Group           (a):
                                                                 (b) X

- --------------------------------------------------------------------------------
  (3) SEC Use Only

- --------------------------------------------------------------------------------
  (4) Source Of Funds*

      AF
- --------------------------------------------------------------------------------
  (5) Check Box If Disclosure Of Legal Proceedings Is Required Pursuant To Items
      2(d) Or 2(e):

- --------------------------------------------------------------------------------
  (6) Citizenship Or Place Of Organization

      U.S.A.
- --------------------------------------------------------------------------------
Number Of Shares                            (7)  Sole Voting Power        -0-
Beneficially Owned
By Each Reporting
Person With                                 (8)  Shared Voting Power      -0-


                                            (9)  Sole Dispositive Power   -0-


                                            (10) Shared Dispositive Power -0-


  (11)   Aggregate Amount Beneficially Owned By Each Reporting Person

                  -0-  Exit Filing
- --------------------------------------------------------------------------------
  (12)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

- --------------------------------------------------------------------------------
  (13)   Percent Of Class Represented By Amount In Row (11)

                  0%   Exit Filing
- --------------------------------------------------------------------------------
  (14)   Type Of Reporting Person

                  IN
- --------------------------------------------------------------------------------

                      *SEE INSTRUCTION BEFORE FILLING OUT!


Item 1. Security and Issuer.

                  This  Statement on Schedule D relates to the Ordinary  Shares,
$0.080 French franc par value per share (the "Shares"),  of Flamel Technologies,
S.A.,  a French  Societe  Anonyme  organized  under the laws of The  Republic of
France  (the  "Company").  The  principal  executive  offices of the Company are
located  at Parc  Club Du  Moulin  a  Vent,  33,  avenue  de Dr.  Georges  Levy,
Venissieux, Cedex 69693, France.

                  EXIT FILING --- On October 2 and 8, 2003, the funds affiliated
with Alta  Partners  sold all its  holdings in Flamel  Technologies,  S.A.  Alta
BioPharma  Partners,   L.P.  sold  1,351,954  shares  (exercised  from  warrants
previously held and  subsequently  converted into ADS's) of the Issuers Ordinary
Stock, Flamel Chase Partners (Alta Bio), LLC sold 772,088 shares (exercised from
warrants previously held and subsequently  converted into ADS's) of the Issuer's
Ordinary Stock and Alta Embarcadero  BioPharma Partners,  LLC sold 50,958 shares
(exercised from warrants previously held and subsequently  converted into ADS's)
of the Issuer's Ordinary Stock.

Item 2. Identity and Background.

                  (a) This Exit Filing is filed by (i) Alta BioPharma  Partners,
L.P., a Delaware limited partnership ("Alta BioPharma") by virtue of having been
a record  owner that sold its  holdings  of  1,351,954  shares  (exercised  from
warrants previously held and subsequently  converted into ADS's) of the Issuer's
Ordinary  Stock on  October  2 and 8,  2003,  (ii)  Alta  Embarcadero  BioPharma
Partners,  LLC, a California  limited liability company  ("Embarcadero  LLC") by
virtue of having been a record  owner that sold 50,958  shares  (exercised  from
warrants previously held and subsequently  converted into ADS's) of the Issuer's
Ordinary  Stock on October 2 and 8, 2003,  and (iii) Flamel Chase Partners (Alta
Bio), LLC, a Delaware limited liability company ("Flamel Alta Bio") by virtue of
having been a record owner that sold its 772,088 shares (exercised from warrants
previously held and subsequently  converted into ADS's) of the Issuer's Ordinary
Stock on October 2 and 8, 2003,  and (iv) Alta  BioPharma  Management  Partners,
LLC, a Delaware  limited  liability  company ("Alta  Management"),  by virtue of
being the sole  general  partner of Alta  BioPharma;  (v)  Alta/Chase  BioPharma
Management LLC, a Delaware limited liability company (Alta/Chase  Management) by
virtue of being the sole managing  member of Flamel Chase  Partners  (Alta Bio),
LLC and (vi) Alta  Partners,  a California  corporation  ("Alta  Partners"),  by
virtue  of  being  the  management  advisory  company  of these  entities.  Alta
BioPharma,  Embarcadero  LLC,  Flamel  Alta  Bio,  Alta  Management,  Alta/Chase
Management  and Alta  Partners are  collectively  referred to as the  "Reporting
Persons." Jean Deleage,  Garrett Gruener,  Daniel Janney, Alix Marduel,  and Guy
Nohra (the "Managing  Directors") are the managing directors and members of Alta
Management,  Alta/Chase  Management and officers of Alta Partners.  By virtue of
the  relationships  described above and their roles with Alta Partners,  each of
the  managing  directors  and  members may be deemed to control  Alta  Partners,
Alta/Chase Management, Alta Management, and, therefore, may be deemed to possess
indirect beneficial ownership of the shares held by each entity.  However,  none
of the managing  directors,  acting alone,  has voting or investment  power with
respect to the shares  directly  beneficially  held by the  entities  and,  as a
result,  the  managing  directors  disclaim  beneficial  ownership of the shares
beneficially owned by each entity,  except to the extent of their  proportionate
pecuniary  interests  therein.  Embarcadero LLC is a side company that makes all
investments pro rata to the capital of Alta BioPharma with all allocations  made
to its members based on paid-in capital.  Certain managing directors are members
of Embarcadero LLC and certain members of Embarcadero LLC are affiliates of Alta
Partners.

                  (b)  The  principal   executive  offices  of  Alta  BioPharma,
Embarcadero LLC, Flamel Chase Alta Bio, Alta Management,  Alta/Chase  Management
and Alta Partners,  and the business address of each Partner, are located at One
Embarcadero Center, Suite 4050, San Francisco, California 94111.

                  (c) Alta Partners  provides  investment  advisory  services to
venture  capital firms.  Alta  BioPharma,  Flamel Chase Alta Bio and Embarcadero
LLC's  principal  business  is acting as venture  capital  investment  vehicles.
Alta/Chase  Management  and Alta  Management's  principal  business is acting as
managing  director of Flamel  Chase Alta Bio and Alta  BioPharma,  respectively.
Each of the Directors'  principal  business is acting as a managing  director of
Alta Management and Alta/Chase Management and as a director of Alta Partners.

          
                    Page 13 of 16 Pages


                  (d) None of the Reporting  Persons or, to the knowledge of the
Reporting  Persons,  any of the  managing  directors,  has been  convicted  in a
criminal  proceeding  in the past five years  (excluding  traffic  violations or
similar misdemeanors).

                  (e) During the past five years,  none of the Reporting Persons
or,  to the  knowledge  of the  Reporting  Persons,  and  none  of the  managing
directors,  was a party to a civil  proceeding  of a judicial or  administrative
body of  competent  jurisdiction  as a result  of which  such  person  was or is
subject to a judgment,  decree or final order enjoining future violations of, or
prohibiting or mandating activities subject to, federal or state securities laws
of finding any violation with respect to such laws.

                  (f) Alta Partners is a California corporation.  Alta BioPharma
is a Delaware  limited  partnership.  Embarcadero  LLC is a  California  limited
liability  corporation.  Flamel Chase Alta Bio is a Delaware  limited  liability
company.   Alta  Management  and  Alta/Chase  Management  are  Delaware  limited
liability  companies.  Each of the Managing Directors is a citizen of the United
States.

                  (g) Jean Deleage resigned his position as a Director of Flamel
Technologies on August 13, 2001. Mr. Deleage owns one share of Ordinary Stock of
Flamel  Technologies  stock.  He is a  managing  director  of  Alta  Management,
Alta/Chase  Management and a managing member of  Embarcadero,  LLC. By virtue of
his  roles  with  Alta  Partners,  he may be  deemed  to share  control  of Alta
Partners,  Alta/Chase Management, Alta Management, and, therefore, may be deemed
to possess  indirect  beneficial  ownership  of the Shares held by each  entity.
However,  he is not acting alone, he has voting or investment power with respect
to the shares directly  beneficially  held by the entities and, as a result,  he
disclaims beneficial ownership of the shares directly beneficially owned by each
entity, except to the extent of their pecuniary interest in each entity.

Item 3. Source and Amount of Funds or Other Consideration.

                  N/A Exit  Filing  --- On  October  2 and 8,  2003,  the  funds
affiliated  with Alta Partners sold all their  holdings in Flamel  Technologies,
S.A.  Alta  BioPharma  Partners,  L.P. sold  1,351,954  shares  (exercised  from
warrants previously held and subsequently  converted into ADS's) of the Issuer's
Ordinary  Stock,  Flamel Chase  Partners  (Alta Bio),  LLC sold  772,088  shares
(exercised from warrants previously held and subsequently  converted into ADS's)
of the Issuer's  Ordinary Stock, and Alta Embarcadero  BioPharma  Partners,  LLC
sold 50,958 shares  (exercised from warrants  previously  held and  subsequently
converted into ADS's) of the Issuer's Ordinary Stock.

Item 4. Purpose of Transaction.

        Exit Filing  --- See Item 3


Item 5. Interest in Securities of the Issuer.

        Exit Filing

Item 6. Contracts, Arrangements, Understandings or Relationships with Respect to
        Securities of the Issuer. Exit Filing

Item 7. Material to be Filed as Exhibits.

        Exhibit A:  Joint Filing Statement

                               Page 14 of 16 Pages


Signature

                  After  reasonable  inquiry and to the best of my knowledge and
belief,  I certify  that the  information  set forth in this  statement is true,
complete and correct.


Date:  October 9, 2003



                                                           
Alta Partners                                                 Alta BioPharma Partners, L.P.

By:               /s/ Jean Deleage                            By:      Alta BioPharma Management, LLC
         --------------------------------------------                  Its General Partner
         Jean Deleage, President


Alta BioPharma Management, LLC                                By:           /s/ Jean Deleage
                                                                       --------------------------------------------
                                                                       Jean Deleage, Managing Director

By:               /s/ Jean Deleage                            Flamel Chase Partners (Alta Bio), LLC
         --------------------------------------------
         Jean Deleage, Managing Director
                                                              By:      Alta/Chase BioPharma Management, LLC
Alta/Chase BioPharma Management, LLC                                   Its Managing Member

By:               /s/ Jean Deleage                            By:           /s/ Jean Deleage
         --------------------------------------------                  --------------------------------------------
         Jean Deleage, Member                                          Jean Deleage, Member

Alta Embarcadero BioPharma Partners, LLC


By:               /s/ Jean Deleage
         --------------------------------------------
         Jean Deleage, Member


         /s/ Jean Deleage                                                   /s/ Guy Nohra
- -----------------------------------------------------         -----------------------------------------------------
Jean Deleage                                                  Guy Nohra

         /s/ Garrett Gruener                                                /s/ Alix Marduel
- -----------------------------------------------------         -----------------------------------------------------
Garrett Gruener                                               Alix Marduel

        /s/ Daniel Janney
- -----------------------------------------------------
Daniel Janney

                               Page 15 of 16 Pages


                                    EXHIBIT A

                             Joint Filing Statement

         We, the  undersigned,  hereby  express our agreement  that the attached
Schedule 13D is filed on behalf of each of us.

Date:  October 9, 2003



                                                           
Alta Partners                                                 Alta BioPharma Partners, L.P.

By:               /s/ Jean Deleage                            By:      Alta BioPharma Management, LLC
         --------------------------------------------                  Its General Partner
         Jean Deleage, President


Alta BioPharma Management, LLC                                By:           /s/ Jean Deleage
                                                                       --------------------------------------------
                                                                       Jean Deleage, Managing Director

By:               /s/ Jean Deleage                            Flamel Chase Partners (Alta Bio), LLC
         --------------------------------------------
         Jean Deleage, Managing Director
                                                              By:      Alta/Chase BioPharma Management, LLC
Alta/Chase BioPharma Management, LLC                                   Its Managing Member

By:               /s/ Jean Deleage                            By:           /s/ Jean Deleage
         --------------------------------------------                  --------------------------------------------
         Jean Deleage, Member                                          Jean Deleage, Member

Alta Embarcadero BioPharma Partners, LLC


By:               /s/ Jean Deleage
         --------------------------------------------
         Jean Deleage, Member


         /s/ Jean Deleage                                                   /s/ Guy Nohra
- -----------------------------------------------------         -----------------------------------------------------
Jean Deleage                                                  Guy Nohra

         /s/ Garrett Gruener                                                /s/ Alix Marduel
- -----------------------------------------------------         -----------------------------------------------------
Garrett Gruener                                               Alix Marduel

        /s/ Daniel Janney
- -----------------------------------------------------
Daniel Janney

                               Page 16 of 16 Pages