Sec Form 4 Filing - BRADBURY DANIEL @ AMYLIN PHARMACEUTICALS INC - 2012-03-01

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL OMB Number: 3235-0287 Expires: November 30, 2011 Estimated average burden hours per response... 0.5

1. Name and Address of Reporting Person BRADBURY DANIEL 2. Issuer Name and Ticker or Trading Symbol AMYLIN PHARMACEUTICALS INC [ AMLN] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner X __ Officer (give title below) X __ Other (specify below) President & Chief Executive Of/President & Chief Executive Of (Last) (First) (Middle) 9360 TOWNE CENTRE DR 3. Date of Earliest Transaction (MM/DD/YY) 03/01/2012 (Street) SAN DIEGO, CA92121 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 03/01/2012 S 1,539 ( 1 ) D $ 17.11 62,912.2 ( 2 ) D Common Stock 03/01/2012 D 4,167 D $ 0 58,745.2 D Common Stock 46,545 I By GRAT ( 3 ) Common Stock 13,456 I Indirect-401k Common Stock 6,445.1 I by ESOP ( 4 ) Common Stock 33,283 I by Trust Common Stock 23,923 I by Trust-1 ( 5 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , put s, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Phantom Stock-Deferred Compensation ( 6 ) 03/01/2012 A 4,167 ( 7 ) ( 7 ) Common Stock 4,167 $ 0 ( 6 ) 137,917 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other BRADBURY DANIEL 9360 TOWNE CENTRE DR SAN DIEGO, CA92121 President & Chief Executive Of President & Chief Executive Of Signatures By: /s/ Attorney-in-Fact, James R. Oehler For: Daniel M. Bradbury 03/02/2012 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Sale of common shares to satisfy reporting person's income tax withholding obligations due upon vesting of restricted stock units. ( 2 )Includes 2,273 shares recently acquired under the Company's Employee Stock Purchase Plan. ( 3 )These shares were previously reported as indirectly beneficially owned by The Bradbury Family Trust but were contributed to a grantor retained annuity trust on July 27, 2010. ( 4 )These shares fully vested four years from the date of the reporting person's participation in the ESOP in four equal annual installments and are generally distributed upon termination of employment. ( 5 )Shares held by the Bradbury Gift Trust, of which the reporting person's minor children are beneficiaries. ( 6 )Represents shares of phantom stock acquired upon vesting of restricted stock units. The reporting person deferred receipt of common shares issuable upon such vesting and instead received shares of phantom stock pursuant to Amylin's Deferred Compensation Plan. ( 7 )Shares of phantom stock are generally distributed to the reporting person in the form of Amylin common stock following termination of employment in accordance with the reporting person's deferral elections.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.