Sec Form 4 Filing - CROOKE STANLEY T @ IONIS PHARMACEUTICALS INC - 2016-04-06

Insider filing report for Changes in Beneficial Ownership
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FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP
Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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1. Name and Address of Reporting Person
CROOKE STANLEY T
2. Issuer Name and Ticker or Trading Symbol
IONIS PHARMACEUTICALS INC [ IONS]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
X __ Director _____ 10% Owner
X __ Officer (give title below) _____ Other (specify below)
Chairman and CEO
(Last) (First) (Middle)
C/O IONIS PHARMACEUTICALS, INC., 2855 GAZELLE COURT
3. Date of Earliest Transaction (MM/DD/YY)
04/06/2016
(Street)
CARLSBAD, CA92010
4. If Amendment, Date Original Filed (MM/DD/YY)
6. Individual or Joint/Group Filing (Check Applicable Line)
__ X __ Form filed by One Reporting Person
_____ Form filed by More than One Reporting Person
(City) (State) (Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 04/06/2016 04/06/2016 M( 1 ) 5,000 ( 1 ) A $ 10.29 30,029 D
Common Stock 04/06/2016 04/06/2016 S( 1 ) 5,000 ( 1 ) D $ 45.95 25,029 D
Common Stock 04/06/2016 04/06/2016 M( 1 ) 5,000 ( 1 ) A $ 10.29 30,029 D
Common Stock 04/06/2016 04/06/2016 S( 1 ) 5,000 ( 1 ) D $ 46.3 25,029 D
Common Stock 04/06/2016 04/06/2016 M( 2 ) 500 ( 2 ) A $ 10.29 2,670 I By wife
Common Stock 04/06/2016 04/06/2016 S( 2 ) 500 ( 2 ) D $ 45.95 2,170 I By wife
Common Stock 04/06/2016 04/06/2016 M( 2 ) 500 ( 2 ) A $ 10.29 2,670 I By wife
Common Stock 04/06/2016 04/06/2016 S( 2 ) 500 ( 2 ) D $ 46.3 2,170 I By wife
Common Stock 725,391 I By trust
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
( e.g. , puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(MM/DD/YY)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Employee Stock Option (right to buy) $ 10.29 04/06/2016 04/06/2016 M 10,000 01/03/2015 01/02/2018 Common Stock 10,000 $ 0 66,259 D
Employee Stock Option (right to buy) $ 10.29 04/06/2016 04/06/2016 M 1,000 01/03/2015 01/02/2018 Common Stock 1,000 $ 0 13,500 I By wife
Reporting Owners
Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
CROOKE STANLEY T
C/O IONIS PHARMACEUTICALS, INC.
2855 GAZELLE COURT
CARLSBAD, CA92010
X Chairman and CEO
Signatures
/s/B. Lynne Parshall, attorney-in-fact 04/07/2016
Signature of Reporting Person Date
Explanation of Responses:
( 1 )Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 9/21/2015.
( 2 )Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person's wife on 9/21/2015.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

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