Sec Form 4 Filing - YANCOPOULOS GEORGE @ REGENERON PHARMACEUTICALS INC - 2015-10-30

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person YANCOPOULOS GEORGE 2. Issuer Name and Ticker or Trading Symbol REGENERON PHARMACEUTICALS INC [ REGN] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) X __ Director _____ 10% Owner X __ Officer (give title below) _____ Other (specify below) President Regeneron Laboratori (Last) (First) (Middle) 777 OLD SAW MILL RIVER ROAD 3. Date of Earliest Transaction (MM/DD/YY) 10/30/2015 (Street) TARRYTOWN, NY10591 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 10/30/2015 M( 1 ) 182,818 A $ 11.64 682,818 D Common Stock 10/30/2015 F( 1 ) 3,806 D $ 559.08 679,012 D Common Stock 10/30/2015 F( 1 ) 92,316 D $ 559.08 586,696 D Common Stock 11/02/2015 S( 1 ) 1,200 D $ 561.75 ( 2 ) 585,496 D Common Stock 11/02/2015 S( 1 ) 100 D $ 562.36 585,396 D Common Stock 11/02/2015 S( 1 ) 530 D $ 563.76 ( 3 ) 584,866 D Common Stock 11/02/2015 S( 1 ) 1,000 D $ 564.57 ( 4 ) 583,866 D Common Stock 11/02/2015 S( 1 ) 1,000 D $ 565.89 ( 5 ) 582,866 D Common Stock 11/02/2015 S( 1 ) 1,700 D $ 566.66 ( 6 ) 581,166 D Common Stock 11/02/2015 S( 1 ) 1,350 D $ 567.61 ( 7 ) 579,816 D Common Stock 11/02/2015 S( 1 ) 1,600 D $ 568.49 ( 8 ) 578,216 D Common Stock 11/02/2015 S( 1 ) 2,223 D $ 569.47 ( 9 ) 575,993 D Common Stock 11/02/2015 S( 1 ) 6,330 D $ 570.67 ( 10 ) 569,663 D Common Stock 11/02/2015 S( 1 ) 7,800 D $ 571.41 ( 11 ) 561,863 D Common Stock 11/02/2015 S( 1 ) 5,723 D $ 572.43 ( 12 ) 556,140 D Common Stock 11/02/2015 S( 1 ) 2,629 D $ 573.47 ( 13 ) 553,511 D Common Stock 11/02/2015 S( 1 ) 2,693 D $ 574.55 ( 14 ) 550,818 D Common Stock 11/02/2015 S( 1 ) 2,441 D $ 575.64 ( 15 ) 548,377 D Common Stock 11/02/2015 S( 1 ) 865 D $ 576.48 ( 16 ) 547,512 D Common Stock 11/02/2015 S( 1 ) 1,996 D $ 577.58 ( 17 ) 545,516 D Common Stock 11/02/2015 S( 1 ) 268 D $ 578.73 ( 18 ) 545,248 D Common Stock 11/02/2015 S( 1 ) 1,500 D $ 579.53 ( 19 ) 543,748 D Common Stock 11/02/2015 S( 1 ) 400 D $ 580.29 ( 20 ) 543,348 D Common Stock 5,654 I By 401(k) Plan Common Stock 569,588 I by Trust

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Non-Qualified Stock Option (right to buy) $ 11.64 10/30/2015 M( 1 ) 182,818 ( 21 ) 12/19/2015 Common Stock 182,818 $ 0 0 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other YANCOPOULOS GEORGE 777 OLD SAW MILL RIVER ROAD TARRYTOWN, NY10591 X President Regeneron Laboratori Signatures /s/**George D. Yancopoulos 11/03/2015 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c). ( 2 )Represents volume-weighted average price of sales of 1,200 shares of Company stock on November 2, 2015 at prices ranging from $561.26 to $561.98. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on November 2, 2015 at each separate price. ( 3 )Represents volume-weighted average price of sales of 530 shares of Company stock on November 2, 2015 at prices ranging from $563.07 to $563.99. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on November 2, 2015 at each separate price. ( 4 )Represents volume-weighted average price of sales of 1,000 shares of Company stock on November 2, 2015 at prices ranging from $564.00 to $564.99. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on November 2, 2015 at each separate price. ( 5 )Represents volume-weighted average price of sales of 1,000 shares of Company stock on November 2, 2015 at prices ranging from $565.78 to $565.99. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on November 2, 2015 at each separate price. ( 6 )Represents volume-weighted average price of sales of 1,700 shares of Company stock on November 2, 2015 at prices ranging from $566.17 to $566.98. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on November 2, 2015 at each separate price. ( 7 )Represents volume-weighted average price of sales of 1,350 shares of Company stock on November 2, 2015 at prices ranging from $567.00 to $567.99. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on November 2, 2015 at each separate price. ( 8 )Represents volume-weighted average price of sales of 1,600 shares of Company stock on November 2, 2015 at prices ranging from $568.00 to $568.87. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on November 2, 2015 at each separate price. ( 9 )Represents volume-weighted average price of sales of 2,223 shares of Company stock on November 2, 2015 at prices ranging from $569.00 to $569.95. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on November 2, 2015 at each separate price. ( 10 )Represents volume-weighted average price of sales of 6,330 shares of Company stock on November 2, 2015 at prices ranging from $570.00 to $570.98. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on November 2, 2015 at each separate price. ( 11 )Represents volume-weighted average price of sales of 7,800 shares of Company stock on November 2, 2015 at prices ranging from $571.00 to $571.96. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on November 2, 2015 at each separate price. ( 12 )Represents volume-weighted average price of sales of 5,723 shares of Company stock on November 2, 2015 at prices ranging from $572.00 to $572.99. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on November 2, 2015 at each separate price. ( 13 )Represents volume-weighted average price of sales of 2,629 shares of Company stock on November 2, 2015 at prices ranging from $573.00 to $573.99. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on November 2, 2015 at each separate price. ( 14 )Represents volume-weighted average price of sales of 2,693 shares of Company stock on November 2, 2015 at prices ranging from $574.00 to $574.99. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on November 2, 2015 at each separate price. ( 15 )Represents volume-weighted average price of sales of 2,441 shares of Company stock on November 2, 2015 at prices ranging from $575.09 to $575.99. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on November 2, 2015 at each separate price. ( 16 )Represents volume-weighted average price of sales of 865 shares of Company stock on November 2, 2015 at prices ranging from $576.16 to $576.94. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on November 2, 2015 at each separate price. ( 17 )Represents volume-weighted average price of sales of 1,996 shares of Company stock on November 2 , 2015 at prices ranging from $577.00 to $577.98. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on November 2, 2015 at each separate price. ( 18 )Represents volume-weighted average price of sales of 268 shares of Company stock on November 2, 2015 at prices ranging from $578.05 to $578.96. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on November 2, 2015 at each separate price. ( 19 )Represents volume-weighted average price of sales of 1,500 shares of Company stock on November 2, 2015 at prices ranging from $579.05 to $579.89. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on November 2, 2015 at each separate price. ( 20 )Represents volume-weighted average price of sales of 400 shares of Company stock on November 2, 2015 at prices ranging from $580.16 to $580.48. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on November 2, 2015 at each separate price. ( 21 )The stock option award (combined incentive stock option and non-qualified stock option) vests in four equal annual installments, commencing one year after the date of grant.

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