Sec Form 4 Filing - Lee Kevin @ BICYCLE THERAPEUTICS plc - 2021-07-12

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Lee Kevin 2. Issuer Name and Ticker or Trading Symbol BICYCLE THERAPEUTICS plc [ BCYC] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) X __ Director _____ 10% Owner X __ Officer (give title below) _____ Other (specify below) Chief Executive Officer (Last) (First) (Middle) C/O BICYCLE THERAPEUTICS PLC, B900, BABRAHAM RESEARCH CAMPUS 3. Date of Earliest Transaction (MM/DD/YY) 07/12/2021 (Street) CAMBRIDGE, X0CB22 3AT 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Ordinary Shares 07/12/2021 M 1,936 A $ 14 256,670 D Ordinary Shares 07/12/2021 S( 1 ) 1,936 D $ 32.04 ( 2 ) 254,734 D Ordinary Shares 07/13/2021 M 35,446 A $ 14 290,180 D Ordinary Shares 07/13/2021 S( 1 ) 21,979 D $ 32.42 ( 3 ) 268,201 D Ordinary Shares 07/13/2021 S( 1 ) 5,788 D $ 33.09 ( 4 ) 262,413 D Ordinary Shares 07/13/2021 S( 1 ) 11,194 D $ 34 251,219 D Ordinary Shares 07/14/2021 M 8,331 A $ 14 259,550 D Ordinary Shares 07/14/2021 S( 1 ) 2,642 D $ 32.93 ( 5 ) 256,908 D Ordinary Shares 07/14/2021 S( 1 ) 2,686 D $ 33.85 ( 6 ) 254,222 D Ordinary Shares 07/14/2021 S( 1 ) 9,084 D $ 34.89 ( 7 ) 245,138 D Ordinary Shares 07/14/2021 S( 1 ) 53 D $ 35.16 245,085 D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Stock Option (right to buy) $ 14 07/12/2021 M 1,936 ( 8 ) 06/28/2029 Ordinary Shares 1,936 $ 0 412,608 D Stock Option (right to buy) $ 14 07/13/2021 M 35,446 ( 8 ) 06/28/2029 Ordinary Shares 35,446 $ 0 377,162 D Stock Option (right to buy) $ 14 07/14/2021 M 8,331 ( 8 ) 06/28/2029 Ordinary Shares 8,331 $ 0 368,831 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Lee Kevin C/O BICYCLE THERAPEUTICS PLC B900, BABRAHAM RESEARCH CAMPUS CAMBRIDGE, X0CB22 3AT X Chief Executive Officer Signatures /s/ Lee Kalowski, Attorney-in-Fact 07/14/2021 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Shares sold pursuant to a Rule 10b5-1 trading plan. ( 2 )The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $32.00 to$32.26 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities andExchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth infootnotes (2), (3), (4), (5), (6) and (7). ( 3 )The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $32.00 to $32.98 inclusive. ( 4 )The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $33.00 to $33.50 inclusive. ( 5 )The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $32.15 to $33.14 inclusive. ( 6 )The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $33.15 to $34.12 inclusive. ( 7 )The price reported in Column 4 is a weighted average price. These shares were sold in multi ple transactions at prices ranging from $34.16 to $35.11 inclusive. ( 8 )This option shall vest in 36 equal monthly installments at the end of each calendar month following the date of the grant.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

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