Sec Form 4 Filing - Madsen Julia @ STERIS plc - 2021-10-01

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Madsen Julia 2. Issuer Name and Ticker or Trading Symbol STERIS plc [ STE] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner X __ Officer (give title below) _____ Other (specify below) Senior VP, Life Sciences (Last) (First) (Middle) C/O 70 SIR ROGER'S QUAY 3. Date of Earliest Transaction (MM/DD/YY) 10/01/2021 (Street) DUBLIN, L22 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Ordinary Shares 10/01/2021 A 576 ( 1 ) A $ 0 6,433 ( 2 ) D Ordinary Shares 10/01/2021 D 121 ( 3 ) D $ 228.36 6,312 ( 2 ) D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Employee Stock Option (right to buy) $ 228.36 10/01/2021 A 3,152 ( 4 ) 10/01/2031 Ordinary Shares 3,152 $ 0 3,152 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Madsen Julia C/O 70 SIR ROGER'S QUAY DUBLIN, L22 Senior VP, Life Sciences Signatures /s/ Ronald E. Snyder, Authorized Representative under Power of Attorney 10/05/2021 Signature of Reporting Person Date

Explanation of Responses:

( 1 )All 576 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 144 on October 3, 2022; 144 on October 2, 2023; 144 on October 1, 2024 and 144 on October 1, 2025. ( 2 )3,737 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 121 on May 31, 2022; 92 on May 31, 2022; 123 on June 1, 2022; 360 on June 2, 2022; 349 on October 3, 2022; 144 on October 3, 2022; 92 on May 31, 2023; 123 on June 1, 2023; 360 on June 2, 2023; 349 on October 2, 2023; 144 on October 2, 2023; 23 on June 3, 2024; 360 on June 3, 2024; 349 on October 1, 2024; 144 on October 1, 2024; 360 on June 2, 2025 and 144 on October 1, 2025. ( 3 )121 shares were withheld from the 349 restricted shares that vested on October 1, 2021. These 121 shares represent the value of the taxes required to be withheld pursuant to applicable employment or tax laws, as determined by the Issuer. These 349 restricted shares were part of an award of 1,396 ordinary shares that were awarded to Ms. Madsen on October 1, 2020. These vested shares were valued at the NYSE closing market price on October 1, 2021. ( 4 )This option becomes exercisable as follows: 788 on October 3, 2022; 788 on October 2, 2023; 788 on October 1, 2024 and 788 on October 1, 2025.

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