Sec Form 4 Filing - Madsen Julia @ STERIS plc - 2021-01-08

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Madsen Julia 2. Issuer Name and Ticker or Trading Symbol STERIS plc [ STE] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner X __ Officer (give title below) _____ Other (specify below) Senior VP, Life Sciences (Last) (First) (Middle) C/O 70 SIR ROGER'S QUAY 3. Date of Earliest Transaction (MM/DD/YY) 01/08/2021 (Street) DUBLIN, L22 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Ordinary Shares 01/08/2021 M 700 A $ 66.15 5,341 D Ordinary Shares 01/08/2021 M 300 A $ 69.72 5,641 D Ordinary Shares 01/08/2021 S 1,000 ( 1 ) D $ 202 4,641 ( 2 ) D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Employee Stock Option (right to buy) $ 66.15 01/08/2021 M 700 ( 3 ) 05/28/2025 Ordinary Shares 700 $ 0 0 D Employee Stock Option (right to buy) $ 69.72 01/08/2021 M 300 ( 4 ) 06/01/2026 Ordinary Shares 300 $ 0 2,400 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Madsen Julia C/O 70 SIR ROGER'S QUAY DUBLIN, L22 Senior VP, Life Sciences Signatures /s/ Ronald E. Snyder, Authorized Representative under Power of Attorney 01/08/2021 Signature of Reporting Person Date

Explanation of Responses:

( 1 )This exercise of stock options and sale of a total of 1,000 ordinary shares is pursuant to a Rule 10b5-1 Stock Trading Plan entered into by the Reporting Person on December 3, 2020. ( 2 )2,714 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 308 on June 1, 2021; 121 on June 1, 2021; 92 on June 1, 2021; 123 on June 1, 2021; 349 on October 1, 2021; 121 on May 31, 2022; 92 on May 31, 2022; 123 on June 1, 2022; 349 on October 3, 2022; 92 on May 31, 2023; 349 on October 2, 2023; 123 on June 1, 2023; 123 on June 3, 2024; and 349 on October 1, 2024. ( 3 )This option to purchase 700 STERIS ordinary shares, which is fully vested, was received in conjunction with the Redomiciliation of the entity organized under the laws of the U.K. and formerly named STERIS plc ("Old STERIS") in exchange for an option to purchase 700 Old STERIS ordinary shares for $66.15 per share, subject to the same terms and conditions as the original Old STERIS stock option, except as otherwise required by law. ( 4 )This option to purchase 300 STERIS ordinary shares, which is fully vested, was received in conjunction with the Redomiciliation of the entity organized under the laws of the U.K. and formerly named STERIS plc ("Old STERIS") in exchange for an option to purchase 300 Old STERIS ordinary shares for $69.72 per share, subject to the same terms and conditions as the original Old STERIS stock option, except as otherwise required by law.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

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