Sec Form 4 Filing - LEWIN NICHOLAS SHERIDAN @ ESTABLISHMENT LABS HOLDINGS INC. - 2019-05-17

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person LEWIN NICHOLAS SHERIDAN 2. Issuer Name and Ticker or Trading Symbol ESTABLISHMENT LABS HOLDINGS INC. [ ESTA] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) X __ Director _____ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) C/O MOTIVA USA LLC, 16192 COASTAL HIGHWAY 3. Date of Earliest Transaction (MM/DD/YY) 05/17/2019 (Street) LEWES, DE19958 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Shares 05/17/2019 P 112 A $ 26.79 8,395( 1 ) I See Footnote Common Shares 05/23/2019 P 45 A $ 21.91 8,440( 1 ) I See Footnote Common Shares 777,763( 2 ) D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other LEWIN NICHOLAS SHERIDAN C/O MOTIVA USA LLC 16192 COASTAL HIGHWAY LEWES, DE19958 X Signatures /s/ Rajbir S. Denhoy, by power of attorney 04/29/2022 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Amount reported includes an additional 8,283 common shares of the Issuer over which the Reporting Person acquired beneficial ownership upon his marriage on November 11, 2018. Does not include 350 common shares of the Issuer subsequently purchased by the Reporting Person's spouse on March 17, 2021 and included on a Form 4 filed with the SEC on March 18, 2021. Taking into account such transaction, as of April 29, 2022, the Reporting Person has indirect beneficial ownership of 8,790 common shares of the Issuer through ownership of such shares by his spouse. ( 2 )Amount reported reflects the Reporting Person's direct beneficial ownership of common shares of the Issuer as of the date of the transactions reported herein. After giving effect to subsequent transactions by the Reporting Person as reported on Form 4 filings with the SEC since the date of the transactions reported herein, the Reporting Person has direct beneficial ownership of 780,463 common shares of the Issuer as of April 29, 2022.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

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