Sec Form 4 Filing - PIERCE GLENN @ Voyager Therapeutics, Inc. - 2022-01-13

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person PIERCE GLENN 2. Issuer Name and Ticker or Trading Symbol Voyager Therapeutics, Inc. [ VYGR] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) X __ Director _____ 10% Owner X __ Officer (give title below) _____ Other (specify below) Interim CSO (Last) (First) (Middle) C/O VOYAGER THERAPEUTICS, INC., 75 SIDNEY STREET 3. Date of Earliest Transaction (MM/DD/YY) 01/13/2022 (Street) CAMBRIDGE, MA02139 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 01/13/2022 A 26,300( 1 ) A $ 0 26,300 D Common Stock 5,000 I See Footnote( 2 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Stock Option (Right to Buy) $ 2.85 01/13/2022 A 50,000 ( 3 ) 01/13/2032 Common Stock 50,000 $ 0 50,000 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other PIERCE GLENN C/O VOYAGER THERAPEUTICS, INC. 75 SIDNEY STREET CAMBRIDGE, MA02139 X Interim CSO Signatures /s/ Robert Hesslein, as Attorney-in-Fact for Glenn Pierce 01/18/2022 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Consists of shares of common stock issuable under an aggregate of 26,300 restricted stock units ("RSUs") awarded to the Reporting Person pursuant to the Voyager Therapeutics, Inc. 2015 Stock Option and Incentive Plan (the "Plan"). Each RSU represents the right to receive one share of common stock upon vesting. The vesting commencement date of the RSU award is the grant date, January 13, 2022. 100% of the shares of common stock underlying the RSU award vest on the six-month anniversary of such vesting commencement date, subject to the Reporting Person's continued service as a director, officer, or otherwise. ( 2 )The securities are directly held by the Pierce Family Trust, dated October 13, 1993 (the "Pierce Family Trust"). The Reporting Person's immediate family members are beneficiaries of the Pierce Family Trust. The Reporting Person expressly disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein. ( 3 )This stock option was issued pursuant to the Plan. 1/5th of the shares of common stock underlying the option vest on each of February 12, 2022, March 12, 2022, April 12, 2022, May 12, 2022 and June 2, 2022, subject to the Reporting Person's continued service as an interim executive officer.

Remarks: Exhibit 24.1: Limited Power of Attorney

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