Sec Form 4 Filing - COLUMN GROUP III, LP @ Revolution Medicines, Inc. - 2020-06-17

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL OMB Number: 3235-0287 Expires: November 30, 2011 Estimated average burden hours per response... 0.5

1. Name and Address of Reporting Person COLUMN GROUP III, LP 2. Issuer Name and Ticker or Trading Symbol Revolution Medicines, Inc. [ RVMD] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director X __ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) 1700 OWENS STREET, SUITE 500 3. Date of Earliest Transaction (MM/DD/YY) 06/17/2020 (Street) SAN FRANCISCO, CA94158 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) _____ Form filed by One Reporting Person __ X __ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 06/17/2020 J 7,234 A $ 0 7,234 ( 1 ) I See Footnote ( 2 ) ( 3 ) Common Stock 7,977,384 ( 4 ) D ( 5 ) ( 6 ) ( 7 ) ( 8 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Stock Option (Right to Buy) $ 36.57 06/17/2020 J 25,318 ( 9 ) 06/16/2030 Common Stock 25,318 $ 0 25,318 I See Footnote ( 2 ) ( 3 ) Stock Option (Right to Buy) $ 17 02/12/2020 J 36,168 ( 10 ) 02/11/2030 Common Stock 36,168 $ 0 36,168 I See Footnote ( 11 )

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other COLUMN GROUP III, LP 1700 OWENS STREET SUITE 500 SAN FRANCISCO, CA94158 X COLUMN GROUP III-A, LP 1700 OWENS STREET SUITE 500 SAN FRANCISCO, CA94158 X COLUMN GROUP III GP, LP 1700 OWENS STREET SUITE 500 SAN FRANCISCO, CA94158 X General Partner PONOI CAPITAL, LP 1700 OWENS STREET SUITE 500 SAN FRANCISCO, CA94158 X Ponoi Capital II, LP 1700 OWENS STREET SUITE 500 SAN FRANCISCO, CA94158 X Ponoi Management, LLC 1700 OWENS STREET SUITE 500 SAN FRANCISCO, CA94158 X General Partner Ponoi II Management, LLC 1700 OWENS STREET SUITE 500 SAN FRANCISCO, CA94158 X General Partner Kutzkey Tim 1700 OWENS STREET SUITE 500 SAN FRANCISCO, CA94158 X Managing Partner GOEDDEL DAVID V 1700 OWENS STREET SUITE 500 SAN FRANCISCO, CA94158 X Managing Partner Signatures /s/ Jennifer J. Carlson, Attorney-in-fact 06/19/2020 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Includes 7,234 restricted stock units. ( 2 )The restricted stock units and option were granted to Peter Svennilson, a director of the Issuer who is a managing partner of The Column Group III GP, LP ("TCG III GP") which is the general partner of The Column Group III, LP ("TCG III LP") and The Column Group III-A, LP ("TCG III-A LP"), and who is a managing partner of Ponoi Management, LLC ("Ponoi LLC") and Ponoi II Management, LLC ("Ponoi II LLC") which are the general partners of Ponoi Capital, LP ("Ponoi LP") and Ponoi Capital II, LP ("Ponoi II LP"), respectively. ( 3 )(cont.) Under the partnership agreements of TCG III LP, TCG III-A LP, Ponoi LP and Ponoi II LP (collectively, the "Funds"), Mr. Svennilson is deemed to hold the restricted stock units and option for the economic benefit of the Funds. The reporting persons may be deemed indirect beneficial owners of the restricted stock units and option. The reporting persons disclaim beneficial ownership of the restricted stock units and option except to the extent of their pecuniary interest therein. ( 4 )Consists of 3,103,049 shares held directly by TCG III LP, 3,504,313 shares held directly by TCG III-A LP, 685,011 shares held directly by Ponoi LP and 685,011 shares held directly by Ponoi II LP. ( 5 )The securities are directly held by TCG III LP, and indirectly held by TCG III GP, the general partner of TCG III LP. The managing partners of TCG III GP are David Goeddel, Peter Svennilson and Tim Kutzkey. The managing partners of TCG III GP may be deemed to have voting and investment power with respect to such shares. TCG III GP and each individual managing partner disclaims beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares. ( 6 )The securities are directly held by TCG III-A LP, and indirectly held by TCG III GP, the general partner of TCG III-A LP. The managing partners of TCG III GP are David Goeddel, Peter Svennilson and Tim Kutzkey. The managing partners of TCG III GP may be deemed to have voting and investment power with respect to such shares. TCG III GP and each individual managing partner disclaims beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares. ( 7 )The securities are directly held by Ponoi II LP, and indirectly held by Ponoi II LLC, the general partner of Ponoi II LP. The managing partners of Ponoi II LLC are David Goeddel, Peter Svennilson and Tim Kutzkey. The managing partners of Ponoi II LLC may be deemed to have voting and investment power with respect to such shares. Ponoi II LLC and each individual managing partner disclaims beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares. ( 8 )The securities are directly held by Ponoi LP, and indirectly held by Ponoi LLC, the general partner of Ponoi LP. The managing partners of Ponoi LLC are David Goeddel, Peter Svennilson and Tim Kutzkey. The managing partners of Ponoi LLC may be deemed to have voting and investment power with respect to such shares. Ponoi LLC and each individual managing partner disclaims beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares. ( 9 )One thirty-sixth (1/36th) of the shares subject to the option will vest on each monthly anniversary measured from June 17, 2020, so that 100% of the shares subject to the option will be fully vested and exercisable as of the third anniversary of such date, subject to Mr. Svennilson's continued service through each vesting date. ( 10 )One thirty-sixth (1/36th) of the shares subject to the option will vest on each monthly anniversary measured from February 12, 2020, so that 100% of the shares subject to the option will be fully vested and exercisable as of the third anniversary of such date, subject to Mr. Lasky's continued service through each vesting date. Mr. Lasky's service as a director of the Issuer ceased on June 17, 2020. ( 11 )The option was granted to Laurence Lasky, a former director of the Issuer who is a partner of the general partners of the Funds. Under the partnership agreements of the Funds, Mr. Lasky is deemed to hold the option for the economic benefit of the Funds. The reporting persons may be deemed indirect beneficial owners of the option. The reporting persons disclaim beneficial ownership of the option except to the extent of their pecuniary interest therein.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.