Sec Form 4 Filing - BARRIS PETER J @ Senseonics Holdings, Inc. - 2017-12-06

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person BARRIS PETER J 2. Issuer Name and Ticker or Trading Symbol Senseonics Holdings, Inc. [ SENS] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director X __ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) 1954 GREENSPRING DRIVE, SUITE 600 3. Date of Earliest Transaction (MM/DD/YY) 12/06/2017 (Street) TIMONIUM, MD21093 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 12/06/2017 X 139,645 A $ 1.7902 139,645 I See Note 1 ( 1 ) Common Stock 12/06/2017 S( 2 ) 94,695 D $ 2.64 44,950 I See Note 1 ( 1 ) Common Stock 12/07/2017 S 12,100 D $ 2.6139 ( 3 ) 32,850 I See Note 1 ( 1 ) Common Stock 12/08/2017 S 32,850 D $ 2.5936 ( 4 ) 0 I See Note 1 ( 1 ) Common Stock 48,377 D Common Stock 21,911,183 I See Note 5 ( 5 ) Common Stock 8,949,292 I See Note 6 ( 6 ) Common Stock 27,791 I See Note 7 ( 7 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Common Stock purchase warrant $ 1.7902 12/06/2017 X 139,645 ( 8 ) 07/15/2021 Common Stock 139,645 $ 0 0 I See Note 1 ( 1 )

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other BARRIS PETER J 1954 GREENSPRING DRIVE SUITE 600 TIMONIUM, MD21093 X Signatures /s/ Sasha Keough, attorney-in-fact 12/08/2017 Signature of Reporting Person Date

Explanation of Responses:

( 1 )The Reporting Person is the sole general partner of NEA Partners VII, Limited Partnership ("NEA Partners VII"). NEA Partners VII is the sole general partner of New Enterprise Associates VII, Limited Partnership ("NEA VII"), the direct beneficial owner of the securities. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA VII shares in which the Reporting Person has no pecuniary interest. ( 2 )On December 6, 2017, NEA VII exercised a warrant to purchase 139,645 shares of the Issuer's common stock for $1.790207 a share. NEA VII paid the exercise price on a cashless basis, resulting in the Issuer withholding 94,695 of the warrant shares to pay the exercise price and issuing to NEA VII the remaining 44,950 shares. ( 3 )The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $2.60 to $2.65, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote (3) to this Form 4. ( 4 )The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $2.57 to $2.64, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote (4) to this Form 4. ( 5 )The Reporting Person is a general partner of NEA Partners 10, Limited Partnership ("NEA Partners 10"). NEA Partners 10 is the sole general partner of New Enterprise Associates 10, Limited Partnership ("NEA 10"), the direct beneficial owner of the securities. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA 10 shares in which the Reporting Person has no pecuniary interest. ( 6 )The Reporting Person is the sole general partner of NEA Partners 9, Limited Partnership ("NEA Partners 9"). NEA Partners 9 is the sole general partner of New Enterprise Associates 9, Limited Partnership ("NEA 9"), the direct beneficial owner of the securities. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA 9 shares in which the Reporting Person has no pecuniary interest. ( 7 )The Reporting Person is the sole general partner of NEA General Partners, L.P. NEA General Partners, L.P. is the sole general partner of NEA Presidents' Fund, L.P. ("NEA Presidents' Fund"), the direct beneficial owner of the securities. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA Presidents' Fund shares in which the Reporting Person has no pecuniary interest. ( 8 )Immediately exercisable.

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