Sec Form 4 Filing - TOMBESI PAOLO @ Epizyme, Inc. - 2019-08-19

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person TOMBESI PAOLO 2. Issuer Name and Ticker or Trading Symbol Epizyme, Inc. [ EPZM] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner X __ Officer (give title below) _____ Other (specify below) Chief Financial Officer (Last) (First) (Middle) C/O EPIZYME, INC., 400 TECHNOLOGY SQUARE 3. Date of Earliest Transaction (MM/DD/YY) 08/19/2019 (Street) CAMBRIDGE, MA02139 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Stock Option (Right to Buy) $ 13.86 08/19/2019 A 132,225 ( 1 ) 08/18/2029 Common Stock 132,225 $ 0 132,225 D Restricted Stock Units ( 2 ) 08/19/2019 A 28,217 ( 3 ) ( 3 ) Common Stock 28,217 $ 0 28,217 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other TOMBESI PAOLO C/O EPIZYME, INC., 400 TECHNOLOGY SQUARE CAMBRIDGE, MA02139 Chief Financial Officer Signatures /s/ Paolo Tombesi 08/21/2019 Signature of Reporting Person Date

Explanation of Responses:

( 1 )This option was granted on August 19, 2019 pursuant to the Company's 2013 Stock Incentive Plan with respect to 132,225 shares of Epizyme, Inc. common stock, with 25% vesting on August 19, 2020 and the remaining 75% vesting in 36 substantially equal monthly installments thereafter. ( 2 )Each restricted stock unit represents the contingent right to receive one share of Epizyme, Inc. common stock upon vesting. ( 3 )This award, granted on August 19, 2019, pursuant to the Company's 2013 Stock Incentive Plan, vests in four equal annual installments beginning August 19, 2020. Vested shares will be delivered to the reporting person.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

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