Sec Form 5/A Filing - William H.C. Chang & Diana Shon Chang TTEE Chang Family Trust U/A DTD 10/23/2006 @ Semler Scientific, Inc. - 2020-12-31

FORM 5/A Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person William H.C. Chang & Diana Shon Chang TTEE Chang Family Trust U/A DTD 10/23/2006 2. Issuer Name and Ticker or Trading Symbol Semler Scientific, Inc. [ SMLR] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director X __ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) C/O SEMLER SCIENTIFIC, INC., 2340-2348 WALSH AVENUE, SUITE 2344 3. Date of Earliest Transaction (MM/DD/YY) 12/31/2020 (Street) SANTA CLARA, CA95051 4. If Amendment, Date Original Filed (MM/DD/YY) 02/16/2021 6. Individual or Joint/Group Filing (Check Applicable Line) _____ Form filed by One Reporting Person __ X __ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 09/03/2020 G 70,101 D $ 0 379,899 D ( 1 ) Common Stock 09/03/2020 G 70,101 D $ 0 379,899 D ( 2 ) Common Stock 09/03/2020 G 140,202 A $ 0 532,525 D ( 3 ) Common Stock 10/09/2020 G 29,523 D $ 0 350,376 D ( 1 ) Common Stock 10/09/2020 G 29,523 D $ 0 350,376 D ( 2 ) Common Stock 10/09/2020 G 59,046 A $ 0 591,571 D ( 3 ) Common Stock 12/04/2020 G 171,618 D $ 0 419,953 D ( 3 ) Common Stock 12/09/2020 G 2,416 D $ 0 417,537 D ( 3 ) Common Stock 12/09/2020 G 2,416 A $ 0 2,416 I ( 4 ) By Limited Liability Company

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other William H.C. Chang & Diana Shon Chang TTEE Chang Family Trust U/A DTD 10/23/2006 C/O SEMLER SCIENTIFIC, INC. 2340-2348 WALSH AVENUE, SUITE 2344 SANTA CLARA, CA95051 X Chang William H C/O SEMLER SCIENTIFIC, INC. 2340-2348 WALSH AVENUE, SUITE 2344 SANTA CLARA, CA95051 X Chang Diana Shon C/O SEMLER SCIENTIFIC, INC. 2340-2348 WALSH AVENUE, SUITE 2344 SANTA CLARA, CA95051 X Chang 2020 GP LLC C/O SEMLER SCIENTIFIC, INC. 2340-2348 WALSH AVENUE, STE. 2344 SANTA CLARA, CA95051 X Signatures /s/ William H.C. Chang, Co-Trustee 02/24/2021 Signature of Reporting Person Date /s/ William H.C. Chang 02/24/2021 Signature of Reporting Person Date /s/ Diana Shon Chang 02/24/2021 Signature of Reporting Person Date /s/ William H.C. Chang, Manager 02/24/2021 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Shares are held in six GRATs, for which Mr. Chang acts as sole Trustee and has voting and investment control. ( 2 )Shares are held in six GRATs, for which Mrs. Chang acts as sole Trustee and has voting and investment control. ( 3 )Shares are held directly by William H.C. Chang & Diana Shon Chang TTEE Chang Family Trust U/A DTD 10/23/2006. ( 4 )Shares are held by Chang 2020 GP LLC, for which Mr. and Mrs. Chang are the sole managers and share voting and investment control.

Remarks: This amendment is being filed solely to include Chang 2020 GP LLC as a co-filer to the original Form 5 filing.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
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