Sec Form 4 Filing - Chione Ltd @ Karyopharm Therapeutics Inc. - 2014-09-26

Insider filing report for Changes in Beneficial Ownership
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FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP
Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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1. Name and Address of Reporting Person
Chione Ltd
2. Issuer Name and Ticker or Trading Symbol
Karyopharm Therapeutics Inc. [ KPTI]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director X __ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last) (First) (Middle)
SIMOU MENARDOU 8, RIA COURT 8, OFFICE 101
3. Date of Earliest Transaction (MM/DD/YY)
09/26/2014
(Street)
6015 LARNACA, G4
4. If Amendment, Date Original Filed (MM/DD/YY)
6. Individual or Joint/Group Filing (Check Applicable Line)
_____ Form filed by One Reporting Person
__ X __ Form filed by More than One Reporting Person
(City) (State) (Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
COMMON STOCK 09/26/2014 S 149,449 D $ 42.4733 ( 1 ) 10,074,318 ( 2 ) ( 3 ) ( 4 ) D
COMMON STOCK 09/26/2014 S 50,551 D $ 43.1566 ( 1 ) 10,023,767 ( 2 ) ( 3 ) ( 4 ) D
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
( e.g. , puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(MM/DD/YY)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Reporting Owners
Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
Chione Ltd
SIMOU MENARDOU 8
RIA COURT 8, OFFICE 101
6015 LARNACA, G4
X
Czernik Marcin
SIMOU MENARDOU 8,
RIA COURT 8, OFFICE 101
6015 LARNACA, G4
X
Hadjimichael Andreas
SIMOU MENARDOU 8,
RIA COURT 8, OFFICE 101
6015 LARNACA, G4
X
Hadjimichael Amalia
SIMOU MENARDOU 8,
RIA COURT 8, OFFICE 101
6015 LARNACA, G4
X
Smolokowski Wiaczeslaw
CHALET LENOTCHKA CH.DE BARNOUD
1885 CHESIERES
SWITZERLAND, G400000
X
Signatures
/s/ Chione Limited, by /s/ Simon Prisk, as attorney-in fact by power of attorney 09/30/2014
Signature of Reporting Person Date
/s/ Marcin Czernik, by /s/ Simon Prisk, as attorney-in fact by power of attorney 09/30/2014
Signature of Reporting Person Date
/s/ Andreas Hadjimichael, by /s/ Simon Prisk, as attorney-in fact by power of attorney 09/30/2014
Signature of Reporting Person Date
/s/ Amalia Hadjimichael, by /s/ Simon Prisk, as attorney-in fact by power of attorney 09/30/2014
Signature of Reporting Person Date
/s/ Wiaczeslaw Smolokowski, by /s/ Simon Prisk, as attorney-in fact by power of attorney 09/30/2014
Signature of Reporting Person Date
Explanation of Responses:
( 1 )The prices reported in Column 4 are weighted average prices. The 149,449 shares referred to in the first row of Column 4 were sold at prices ranging from $ 42.00 to $ 42.985, inclusive. The 51,551 shares referred to in the second row of Column 4 were sold at prices ranging from $43.00 to $43.96, inclusive. The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within each of the ranges set forth in this footnote.
( 2 )Shares of Common Stock are owned directly by Chione Limited ("Chione") , which holds less than 10% of the outstanding Common Stock of the issuer. Chione's directors, Marcin Czernik, Andreas Hadjimichael and Amalia Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. The shares owned by Chione do not include the shares of the issuer's Common Stock held by Plio Limited, which has the same directors as Chione.
( 3 )Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed, except, with respect to any person, to the extent of the pecuniary interest of such person in such securities.
( 4 )Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

Remarks:
Exhibit Index Exhibit 24.1 - Power of Attorney, dated November 5, 2013, made by Marcin Czernik and Chione Limited in favor of Simon Prisk (previously filed) Exhibit 24.2 - Power of Attorney, dated November 5, 2013, made by Andreas Hadjimichael and Chione Limited in favor of Simon Prisk (previously filed) Exhibit 24.3 - Power of Attorney, dated November 5, 2013, made by Amalia Hadjimichael and Chione Limited in favor of Simon Prisk (previously filed) ) Exhibit 24.4 - Power of Attorney, dated November 5, 2013, made by Wiaczeslaw Smolokowski in favor of Simon Prisk (previously filed) Exhibit 99.1 - Joint Filer Information (filed herewith) Exhibit 99.2 - Joint Filing Agreement (previously filed) All previously filed Exhibits were filed with the Form 3 of the reporting persons, filed on November 8, 2013.

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