Sec Form 3 Filing - Panagos Constantinos @ IQVIA HOLDINGS INC. - 2022-03-17

FORM 3 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Panagos Constantinos 2. Issuer Name and Ticker or Trading Symbol IQVIA HOLDINGS INC. [ IQV] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner X __ Officer (give title below) _____ Other (specify below) See Remarks (Last) (First) (Middle) C/O IQVIA HOLDINGS INC., 4820 EMPEROR BLVD. 3. Date of Earliest Transaction (MM/DD/YY) 03/17/2022 (Street) DURHAM, NC27703 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 37,219( 1 ) D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Stock Appreciation Right $ 95.23 02/08/2021 02/08/2028 Common Stock 2,853 D Stock Appreciation Right $ 131.82 02/13/2022 02/13/2029 Common Stock 7,681 D Stock Appreciation Right $ 161.7 ( 2 ) 02/11/2030 Common Stock 11,202 D Stock Appreciation Right $ 183.82 ( 3 ) 02/09/2031 Common Stock 6,675 D Stock Appreciation Right $ 250.43 ( 4 ) 02/10/2032 Common Stock 7,283 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Panagos Constantinos C/O IQVIA HOLDINGS INC. 4820 EMPEROR BLVD. DURHAM, NC27703 See Remarks Signatures /s/ Matthew Gilmartin, Attorney-in-Fact for Constantinos Panagos 03/17/2022 Signature of Reporting Person Date

Explanation of Responses:

( 1 )This amount includes 4,090 RSUs granted on November 1, 2018 which will vest on November 1, 2022, 6,253 RSUs granted on February 11, 2020 which will vest in two annual installments beginning on February 11, 2023, 1,114 RSUs granted on February 9, 2021 which will vest in two annual installments beginning on February 9, 2023, 10,700 RSUs granted on February 9, 2021 which will vest in two annual installments beginning on February 9, 2023, 1,956 RSUs granted on February 10, 2022 which will vest in three annual installments beginning on February 10, 2023 and 3,912 RSUs granted on February 10, 2022 which will vest in two annual installments beginning on February 10, 2024. ( 2 )This stock appreciation right remains outstanding under the grant; 7,468 of which are currently vested; and 3,734 of which will vest on February 11, 2023. ( 3 )This stock appreciation right remains outstanding under the grant; 2,225 of which are currently vested; and 4,450 of which will vest in two annual installments beginning on February 9, 2023. ( 4 )This stock appreciation right vests in three annual installments beginning on February 10, 2023.

Remarks: President, Research & Development SolutionsPower of Attorney

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