Sec Form 4 Filing - Osage University Partners II, L.P. @ SELECTA BIOSCIENCES INC - 2016-06-27

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Osage University Partners II, L.P. 2. Issuer Name and Ticker or Trading Symbol SELECTA BIOSCIENCES INC [ SELB] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director X __ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) 50 MONUMENT ROAD,, SUITE 201 3. Date of Earliest Transaction (MM/DD/YY) 06/27/2016 (Street) BALA CYNWYD, PA19004 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) _____ Form filed by One Reporting Person __ X __ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 06/27/2016 C 441,628 A $ 0 512,543 I See Footnote ( 1 ) Common Stock 06/27/2016 P 350,000 A $ 14 862,543 I See Footnote ( 1 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Series E Convertible Preferred Stock ( 2 ) 06/27/2016 C 284,900 ( 2 ) ( 2 ) Common Stock 441,628 $ 0 0 I See Footnote ( 1 )

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Osage University Partners II, L.P. 50 MONUMENT ROAD, SUITE 201 BALA CYNWYD, PA19004 X Osage University GP II, L.P. 50 MONUMENT ROAD, SUITE 201 BALA CYNWYD, PA19004 X Osage Partners, LLC 50 MONUMENT ROAD, SUITE 201 BALA CYNWYD, PA19004 X Signatures OSAGE UNIVERSITY PARTNERS II, L.P. By: Osage University GP II, LP, its GP By: Osage Partners, LLC, its GP By: /s/ William Harrington, Member 06/29/2016 Signature of Reporting Person Date OSAGE UNIVERSITY GP II, LP By: Osage Partners, LLC, its GP By: /s/ William Harrington, Member 06/29/2016 Signature of Reporting Person Date OSAGE PARTNERS, LLC By: /s/ William Harrington, Member 06/29/2016 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Held by Osage University Partners II, L.P. ("Osage"). Osage Partners, LLC ("Osage Partners") is the general parter of Osage University GP II, LP ("Osage GP"), which is the general partner of Osage. Osage Partners and Osage GP may be deemed to share voting and investment power with respect to all shares held by Osage. Each of the filing persons disclaims beneficial ownership of the securities reported herein except to the extent of their pecuniary interest therein. ( 2 )The Series E Convertible Preferred Stock is convertible at any time, at the holder's election and has no expiration date. The Series E Convertible Preferred Stock automatically converted into common stock on an approximately 1-for-1.550115 basis upon the closing of the Issuer's initial public offering.

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