Sec Form 4 Filing - COLUMN GROUP L P @ Immune Design Corp. - 2017-10-27

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person COLUMN GROUP L P 2. Issuer Name and Ticker or Trading Symbol Immune Design Corp. [ IMDZ] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director X __ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) 1700 OWENS STREET, SUITE 500 3. Date of Earliest Transaction (MM/DD/YY) 10/27/2017 (Street) SAN FRANCISCO, CA94158 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) _____ Form filed by One Reporting Person __ X __ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 10/27/2017 P 2,681,000 ( 1 ) A $ 4.1 6,642,942 D ( 2 ) ( 3 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other COLUMN GROUP L P 1700 OWENS STREET, SUITE 500 SAN FRANCISCO, CA94158 X COLUMN GROUP GP, LP 1700 OWENS STREET, SUITE 500 SAN FRANCISCO, CA94158 X COLUMN GROUP II, LP 1700 OWENS STREET, SUITE 500 SAN FRANCISCO, CA94158 X Column Group II GP, LP 1700 OWENS STREET, SUITE 500 SAN FRANCISCO, CA94158 X PONOI CAPITAL, LP 1700 OWENS STREET, SUITE 500 SAN FRANCISCO, CA94158 X Ponoi Management, LLC 1700 OWENS STREET, SUITE 500 SAN FRANCISCO, CA94158 X GOEDDEL DAVID V 1700 OWENS STREET, SUITE 500 SAN FRANCISCO, CA94158 X Kutzkey Tim 1700 OWENS STREET, SUITE 500 SAN FRANCISCO, CA94158 X Signatures THE COLUMN GROUP, LP, /s/ Peter Svennilson, Name: Peter Svennilson, Managing Partner 10/30/2017 Signature of Reporting Person Date THE COLUMN GROUP GP, LP, /s/ Peter Svennilson, Name: Peter Svennilson, Managing Partner 10/30/2017 Signature of Reporting Person Date THE COLUMN GROUP II, LP, /s/ Peter Svennilson, Name: Peter Svennilson, Managing Partner 10/30/2017 Signature of Reporting Person Date THE COLUMN GROUP II GP, LP, /s/ Peter Svennilson, Name: Peter Svennilson, Managing Partner 10/30/2017 Signature of Reporting Person Date PONOI CAPITAL, LP, /s/ Peter Svennilson, Name: Peter Svennilson, Managing Partner 10/30/2017 Signature of Reporting Person Date PONOI MANAGEMENT, LLC, /s/ Peter Svennilson, Name: Peter Svennilson, Managing Partner 10/30/2017 Signature of Reporting Person Date /s/ David V. Goeddel, Name: David V. Goeddel 10/30/2017 Signature of Reporting Person Date /s/ Tim Kutzkey, Name: Tim Kutzky 10/30/2017 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Reflects the purchase of shares by Ponoi Capital, LP ("Ponoi LP") in the follow-on offering of Common Stock of Immune Design Corp. that closed on October 27, 2017. ( 2 )Includes shares directly held by Ponoi LP, The Column Group II, LP ("TCG II LP") and The Column Group, LP ("TCG LP"). The Column Group II GP, LP ("TCG II GP"), as the general partner of TCG II LP, has voting and dispositive power with respect to certain of the shares. The Column Group GP, LP ("TCG GP"), as the general partner of TCG LP, has voting and dispositive power with respect to certain of the shares. Ponoi Management, LLC ("Ponoi LLC"), as the general partner of Ponoi LP, has voting and dispositive power with respect to certain of the shares. ( 3 )(Continued From Footnote 2) The individual managing partners of both TCG II GP and TCG GP are Peter Svennilson and David Goeddel, who may be deemed to have shared voting and dispositive power with respect to the shares owned by TCG II LP and TCG LP. The individual managing partners of Ponoi LLC are Peter Svennilson, David Goeddel and Tim Kutzkey, who may be deemed to have shared voting and dispositive power with respect to the shares owned by Ponoi LP. Each individual managing partner disclaims beneficial ownership of the shares, except to the extent of his pecuniary interest in such shares.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

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