Sec Form 4 Filing - Kola Ismail @ ATHERSYS, INC / NEW - 2022-09-16

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Kola Ismail 2. Issuer Name and Ticker or Trading Symbol ATHERSYS, INC / NEW [ ATHX] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) X __ Director _____ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) 3201 CARNEGIE AVENUE 3. Date of Earliest Transaction (MM/DD/YY) 09/16/2022 (Street) CLEVELAND, OH44115-2634 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 09/16/2022 A 20,512( 1 ) A $ 0 24,512( 2 ) D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Stock Option (right to purchase) $ 1.95 09/16/2022 A 32,042 ( 3 ) 09/16/2032 Common Stock 32,042 $ 0 32,042 D Stock Option (right to purchase)( 4 ) $ 38.5 ( 5 ) 06/15/2031 Common Stock 2,000 2,000 D Stock Option (right to purchase)( 4 ) $ 50 06/15/2020 03/11/2031 Common Stock 4,000 4,000 D Stock Option (right to purchase)( 4 ) $ 71.75 ( 5 ) 06/18/2030 Common Stock 2,000 2,000 D Stock Option (right to purchase)( 4 ) $ 38.75 ( 5 ) 06/12/2029 Common Stock 2,000 2,000 D Stock Option (right to purchase)( 4 ) $ 57.75 ( 5 ) 06/18/2028 Common Stock 2,000 2,000 D Stock Option (right to purchase)( 4 ) $ 36.5 ( 5 ) 06/07/2027 Common Stock 1,200 1,200 D Stock Option (right to purchase)( 4 ) $ 54.75 ( 5 ) 06/20/2026 Common Stock 1,200 1,200 D Stock Option (right to purchase)( 4 ) $ 46 ( 6 ) 03/07/2026 Common Stock 3,000 3,000 D Stock Option (right to purchase)( 4 ) $ 32 ( 5 ) 06/24/2025 Common Stock 1,200 1,200 D Stock Option (right to purchase)( 4 ) $ 41.25 ( 5 ) 06/17/2024 Common Stock 1,200 1,200 D Stock Option (right to purchase)( 4 ) $ 42.75 ( 5 ) 09/10/2023 Common Stock 600 600 D Stock Option (right to purchase)( 4 ) $ 42.75 ( 5 ) 06/18/2023 Common Stock 600 600 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Kola Ismail 3201 CARNEGIE AVENUE CLEVELAND, OH44115-2634 X Signatures /s/ Barb Cameron, as attorney-in-fact for Ismail Kola 09/20/2022 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Represents the exempt acquisition of 20,512 restricted stock units that in general will vest in total on December 31, 2022, subject generally to the Reporting Person's continued service on the Issuer's Board of Directors. ( 2 )On August 26, 2022, the Issuer effected a 1-for-25 reverse stock split of its Common Stock (the "Reverse Stock Split"), resulting in a decrease in the Reporting Person's ownership by 96,000 shares. ( 3 )Represents the exempt acquisition of stock options to purchase 32,042 shares of the Issuer's Common Stock at a per share exercise price of $1.95. These stock options in general will vest on July 28, 2023, subject generally to the Reporting Person's continued service on the Issuer's Board of Directors. ( 4 )This option has been adjusted to reflect the Reverse Stock Split (in prior reports, this option was previously reported as covering a number of shares equal to this reported amount times 25 (and at an exercise price equal to this reported exercise price divided by 25)). ( 5 )Award of a nonqualified stock option. The option vests ratably on a quarterly basis over a one-year period and are now fully vested. ( 6 )These stock options vested ratably on a quarterly basis over three years and are now fully vested

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

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