Insider Trading - Holmes W Stephen - Portfolio Holdings (Majority Ownership)

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Sec Filings Insider Trading - Holmes W Stephen - Portfolio Holdings (Majority Ownership)

"Insiders might sell their shares for any number of reasons, but they buy them for only one: they think the price will rise"
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Insider Trading Transactions for Holmes W Stephen

Holmes W Stephen: Insider Trading and Stock Options

Common stock purchase or sale:

Transaction & Date	Reported Date	Company	Symbol	Insider Relationship	Shares Traded	Average Price	Total Amount	Shares Ownership	Filing
2008-04-16 Purchase	2008-04-18 2:04 pm	METABASIS THERAPEUTICS INC	MBRX	Holmes W Stephen INTERWEST PARTNERS VII L P InterWest Investors VII, LP INTERWEST MANAGEMENT PARTNERS VII LLC CASH HARVEY B GIANOS PHILIP T HEDRICK W SCOTT Kliman Gilbert H Rosch Thomas L (10% owner)	990,816	$2.34	$2,318,509	165,459 (Direct Indirect)	View
2007-12-18 Purchase	2007-12-20 12:19 pm	ANESIVA, INC.	ANSV	Holmes W Stephen INTERWEST PARTNERS VIII LP INTERWEST INVESTORS VIII L P INTERWEST INVESTORS Q VIII LP CASH HARVEY B Ehrlich Christopher B GIANOS PHILIP T HEDRICK W SCOTT Kliman Gilbert H Nash H Ronald (10% owner)	1,975,309	$4.05	$8,000,001	132,388 (Direct Indirect)	View
2007-11-15 Purchase	2007-11-19 4:51 pm	EnteroMedics Inc	ETRM	Holmes W Stephen InterWest Partners IX, LP CASH HARVEY B GIANOS PHILIP T Kliman Gilbert H ORONSKY ARNOLD L Rosch Thomas L SWEENEY MICHAEL B BOICH MICHAEL D CLEVELAND BRUCE A (10% owner)	187,500	$8	$1,500,000	187,500 (Direct)	View
2005-09-30 Purchase	2005-10-04 8:15 pm	METABASIS THERAPEUTICS INC	MBRX	Holmes W Stephen INTERWEST PARTNERS VII L P InterWest Investors VII, LP INTERWEST MANAGEMENT PARTNERS VII LLC Bowsher Stephen C CASH HARVEY B GIANOS PHILIP T HEDRICK W SCOTT Kliman Gilbert H Rosch Thomas L (10% owner)	426,621	$5.86	$2,499,999	120,220 (Direct Indirect)	View
2004-06-21 Purchase	2004-06-23 9:06 pm	METABASIS THERAPEUTICS INC	MBRX	Holmes W Stephen INTERWEST PARTNERS VII L P INTERWEST MANAGEMENT PARTNERS VII LLC InterWest Investors VII, LP Bowsher Stephen C CASH HARVEY B GIANOS PHILIP T HEDRICK W SCOTT Kliman Gilbert H ORONSKY ARNOLD L (10% owner)	130,000	$7	$910,000	5,941 (Direct Indirect)	View

Other transactions:

Transaction & Date	Reported Date	Company	Symbol	Insider Relationship	Shares Traded	Average Price	Total Amount	Shares Ownership	Filing
2008-04-16 Exercise	2008-04-18 2:04 pm	METABASIS THERAPEUTICS INC	MBRX	Holmes W Stephen INTERWEST PARTNERS VII L P InterWest Investors VII, LP INTERWEST MANAGEMENT PARTNERS VII LLC CASH HARVEY B GIANOS PHILIP T HEDRICK W SCOTT Kliman Gilbert H Rosch Thomas L (10% owner)	273,763	$2.34	$640,605	177,970 (Direct Indirect)	View
2007-11-20 Purchase	2007-11-21 06:13 am	EnteroMedics Inc	ETRM	Holmes W Stephen InterWest Partners IX, LP CASH HARVEY B GIANOS PHILIP T Kliman Gilbert H ORONSKY ARNOLD L Rosch Thomas L SWEENEY MICHAEL B BOICH MICHAEL D CLEVELAND BRUCE A (10% owner)	1,359,261	$0	$0	1,546,761 (Direct)	View
2005-06-28 Other	2005-06-30 8:11 pm	MYOGEN INC	MYOG	Holmes W Stephen INTERWEST PARTNERS VI L P InterWest Management Partners VI, LLC CASH HARVEY B GIANOS PHILIP T HEDRICK W SCOTT Kliman Gilbert H MOMSEN ROBERT R InterWest Investors VI, LP (10% owner)	288,149	$0	$0	398 (Direct Indirect)	View
2005-06-07 Other	2005-06-09 7:52 pm	INTRALASE CORP	ILSE	Holmes W Stephen INTERWEST PARTNERS VIII LP INTERWEST INVESTORS VIII L P INTERWEST INVESTORS Q VIII LP InterWest Management Partners VIII, LLC Bowsher Stephen C Ehrlich Christopher B GIANOS PHILIP T ORONSKY ARNOLD L Rosch Thomas L (10% owner)	1,739,616	$0	$0	545 (Direct Indirect)	View
2004-10-13 Purchase	2004-10-13 6:09 pm	INTRALASE CORP	ILSE	Holmes W Stephen INTERWEST PARTNERS VIII LP INTERWEST INVESTORS VIII L P INTERWEST INVESTORS Q VIII LP InterWest Management Partners VIII, LLC Ehrlich Christopher B ORONSKY ARNOLD L GIANOS PHILIP T Bowsher Stephen C Rosch Thomas L (10% owner)	3,387,377	$0	$0	5,155 (Indirect)	View
2004-06-21 Purchase	2004-06-23 9:06 pm	METABASIS THERAPEUTICS INC	MBRX	Holmes W Stephen INTERWEST PARTNERS VII L P INTERWEST MANAGEMENT PARTNERS VII LLC InterWest Investors VII, LP Bowsher Stephen C CASH HARVEY B GIANOS PHILIP T HEDRICK W SCOTT Kliman Gilbert H ORONSKY ARNOLD L (10% owner)	2,074,052	$0	$0	94,782 (Direct Indirect)	View

Stock options: Exercise, Award, Grant, Conversion

Transaction & Date	Reported Date	Exercisable Expiration	Company	Symbol	Insider Relationship	Shares Traded	Conversion Price	Shares Ownership	Filing
2008-04-16 Expired	2008-04-18 2:04 pm	2004-06-16 2008-04-16	METABASIS THERAPEUTICS INC	MBRX	Holmes W Stephen INTERWEST PARTNERS VII L P InterWest Investors VII, LP INTERWEST MANAGEMENT PARTNERS VII LLC CASH HARVEY B GIANOS PHILIP T HEDRICK W SCOTT Kliman Gilbert H Rosch Thomas L (10% owner)	118,759	$8.694	0 (Direct)	View
2008-04-16 Expired	2008-04-18 2:04 pm	2006-03-29 2008-04-16	METABASIS THERAPEUTICS INC	MBRX	Holmes W Stephen INTERWEST PARTNERS VII L P InterWest Investors VII, LP INTERWEST MANAGEMENT PARTNERS VII LLC CASH HARVEY B GIANOS PHILIP T HEDRICK W SCOTT Kliman Gilbert H Rosch Thomas L (10% owner)	142,493	$6.74	0 (Direct)	View
2008-04-16 Expired	2008-04-18 2:04 pm	2004-06-16 2008-04-16	METABASIS THERAPEUTICS INC	MBRX	Holmes W Stephen INTERWEST PARTNERS VII L P InterWest Investors VII, LP INTERWEST MANAGEMENT PARTNERS VII LLC CASH HARVEY B GIANOS PHILIP T HEDRICK W SCOTT Kliman Gilbert H Rosch Thomas L (10% owner)	5,687	$8.694	0 (Indirect)	View
2008-04-16 Expired	2008-04-18 2:04 pm	2006-03-29 2008-04-16	METABASIS THERAPEUTICS INC	MBRX	Holmes W Stephen INTERWEST PARTNERS VII L P InterWest Investors VII, LP INTERWEST MANAGEMENT PARTNERS VII LLC CASH HARVEY B GIANOS PHILIP T HEDRICK W SCOTT Kliman Gilbert H Rosch Thomas L (10% owner)	6,824	$6.74	0 (Indirect)	View
2008-04-16 Purchase	2008-04-18 2:04 pm	2008-04-16 2008-04-16	METABASIS THERAPEUTICS INC	MBRX	Holmes W Stephen INTERWEST PARTNERS VII L P InterWest Investors VII, LP INTERWEST MANAGEMENT PARTNERS VII LLC CASH HARVEY B GIANOS PHILIP T HEDRICK W SCOTT Kliman Gilbert H Rosch Thomas L (10% owner)	118,759	$2.34	118,759 (Direct)	View
2008-04-16 Purchase	2008-04-18 2:04 pm	2008-04-16 2008-04-16	METABASIS THERAPEUTICS INC	MBRX	Holmes W Stephen INTERWEST PARTNERS VII L P InterWest Investors VII, LP INTERWEST MANAGEMENT PARTNERS VII LLC CASH HARVEY B GIANOS PHILIP T HEDRICK W SCOTT Kliman Gilbert H Rosch Thomas L (10% owner)	142,493	$2.34	142,493 (Direct)	View
2008-04-16 Purchase	2008-04-18 2:04 pm	2008-04-16 2008-04-16	METABASIS THERAPEUTICS INC	MBRX	Holmes W Stephen INTERWEST PARTNERS VII L P InterWest Investors VII, LP INTERWEST MANAGEMENT PARTNERS VII LLC CASH HARVEY B GIANOS PHILIP T HEDRICK W SCOTT Kliman Gilbert H Rosch Thomas L (10% owner)	5,687	$2.34	5,687 (Indirect)	View
2008-04-16 Purchase	2008-04-18 2:04 pm	2008-04-16 2008-04-16	METABASIS THERAPEUTICS INC	MBRX	Holmes W Stephen INTERWEST PARTNERS VII L P InterWest Investors VII, LP INTERWEST MANAGEMENT PARTNERS VII LLC CASH HARVEY B GIANOS PHILIP T HEDRICK W SCOTT Kliman Gilbert H Rosch Thomas L (10% owner)	6,824	$2.34	6,824 (Indirect)	View
2008-04-16 Exercise	2008-04-18 2:04 pm	2008-04-16 2008-04-16	METABASIS THERAPEUTICS INC	MBRX	Holmes W Stephen INTERWEST PARTNERS VII L P InterWest Investors VII, LP INTERWEST MANAGEMENT PARTNERS VII LLC CASH HARVEY B GIANOS PHILIP T HEDRICK W SCOTT Kliman Gilbert H Rosch Thomas L (10% owner)	118,759	$2.34	0 (Direct)	View
2008-04-16 Exercise	2008-04-18 2:04 pm	2008-04-16 2008-04-16	METABASIS THERAPEUTICS INC	MBRX	Holmes W Stephen INTERWEST PARTNERS VII L P InterWest Investors VII, LP INTERWEST MANAGEMENT PARTNERS VII LLC CASH HARVEY B GIANOS PHILIP T HEDRICK W SCOTT Kliman Gilbert H Rosch Thomas L (10% owner)	142,493	$2.34	0 (Direct)	View
2008-04-16 Exercise	2008-04-18 2:04 pm	2008-04-16 2008-04-16	METABASIS THERAPEUTICS INC	MBRX	Holmes W Stephen INTERWEST PARTNERS VII L P InterWest Investors VII, LP INTERWEST MANAGEMENT PARTNERS VII LLC CASH HARVEY B GIANOS PHILIP T HEDRICK W SCOTT Kliman Gilbert H Rosch Thomas L (10% owner)	5,687	$2.34	0 (Indirect)	View
2008-04-16 Exercise	2008-04-18 2:04 pm	2008-04-16 2008-04-16	METABASIS THERAPEUTICS INC	MBRX	Holmes W Stephen INTERWEST PARTNERS VII L P InterWest Investors VII, LP INTERWEST MANAGEMENT PARTNERS VII LLC CASH HARVEY B GIANOS PHILIP T HEDRICK W SCOTT Kliman Gilbert H Rosch Thomas L (10% owner)	6,824	$2.34	0 (Indirect)	View
2008-04-16 Purchase	2008-04-18 2:04 pm	2008-10-16 2013-04-16	METABASIS THERAPEUTICS INC	MBRX	Holmes W Stephen INTERWEST PARTNERS VII L P InterWest Investors VII, LP INTERWEST MANAGEMENT PARTNERS VII LLC CASH HARVEY B GIANOS PHILIP T HEDRICK W SCOTT Kliman Gilbert H Rosch Thomas L (10% owner)	312,173	$2.69	312,173 (Direct)	View
2008-04-16 Purchase	2008-04-18 2:04 pm	2008-10-16 2013-04-16	METABASIS THERAPEUTICS INC	MBRX	Holmes W Stephen INTERWEST PARTNERS VII L P InterWest Investors VII, LP INTERWEST MANAGEMENT PARTNERS VII LLC CASH HARVEY B GIANOS PHILIP T HEDRICK W SCOTT Kliman Gilbert H Rosch Thomas L (10% owner)	14,937	$2.69	14,937 (Indirect)	View
2007-11-20 Purchase	2007-11-21 06:13 am	N/A N/A	EnteroMedics Inc	ETRM	Holmes W Stephen InterWest Partners IX, LP CASH HARVEY B GIANOS PHILIP T Kliman Gilbert H ORONSKY ARNOLD L Rosch Thomas L SWEENEY MICHAEL B BOICH MICHAEL D CLEVELAND BRUCE A (10% owner)	1,359,261	$0	0 (Direct)	View
2005-09-30 Purchase	2005-10-04 8:15 pm	2006-03-29 2010-09-30	METABASIS THERAPEUTICS INC	MBRX	Holmes W Stephen INTERWEST PARTNERS VII L P InterWest Investors VII, LP INTERWEST MANAGEMENT PARTNERS VII LLC Bowsher Stephen C CASH HARVEY B GIANOS PHILIP T HEDRICK W SCOTT Kliman Gilbert H Rosch Thomas L (10% owner)	142,493	$6.74	142,493 (Direct)	View
2005-09-30 Purchase	2005-10-04 8:15 pm	2006-03-29 2010-09-30	METABASIS THERAPEUTICS INC	MBRX	Holmes W Stephen INTERWEST PARTNERS VII L P InterWest Investors VII, LP INTERWEST MANAGEMENT PARTNERS VII LLC Bowsher Stephen C CASH HARVEY B GIANOS PHILIP T HEDRICK W SCOTT Kliman Gilbert H Rosch Thomas L (10% owner)	6,824	$6.74	6,824 (Indirect)	View
2004-10-13 Purchase	2004-10-13 6:09 pm	N/A N/A	INTRALASE CORP	ILSE	Holmes W Stephen INTERWEST PARTNERS VIII LP INTERWEST INVESTORS VIII L P INTERWEST INVESTORS Q VIII LP InterWest Management Partners VIII, LLC Ehrlich Christopher B ORONSKY ARNOLD L GIANOS PHILIP T Bowsher Stephen C Rosch Thomas L (10% owner)	2,263,797	$0	0 (Indirect)	View
2004-10-13 Purchase	2004-10-13 6:09 pm	N/A N/A	INTRALASE CORP	ILSE	Holmes W Stephen INTERWEST PARTNERS VIII LP INTERWEST INVESTORS VIII L P INTERWEST INVESTORS Q VIII LP InterWest Management Partners VIII, LLC Ehrlich Christopher B ORONSKY ARNOLD L GIANOS PHILIP T Bowsher Stephen C Rosch Thomas L (10% owner)	64,814	$0	0 (Indirect)	View
2004-10-13 Purchase	2004-10-13 6:09 pm	N/A N/A	INTRALASE CORP	ILSE	Holmes W Stephen INTERWEST PARTNERS VIII LP INTERWEST INVESTORS VIII L P INTERWEST INVESTORS Q VIII LP InterWest Management Partners VIII, LLC Ehrlich Christopher B ORONSKY ARNOLD L GIANOS PHILIP T Bowsher Stephen C Rosch Thomas L (10% owner)	19,726	$0	0 (Indirect)	View
2004-10-13 Purchase	2004-10-13 6:09 pm	N/A N/A	INTRALASE CORP	ILSE	Holmes W Stephen INTERWEST PARTNERS VIII LP INTERWEST INVESTORS VIII L P INTERWEST INVESTORS Q VIII LP InterWest Management Partners VIII, LLC Ehrlich Christopher B ORONSKY ARNOLD L GIANOS PHILIP T Bowsher Stephen C Rosch Thomas L (10% owner)	920,632	$0	0 (Indirect)	View
2004-10-13 Purchase	2004-10-13 6:09 pm	N/A N/A	INTRALASE CORP	ILSE	Holmes W Stephen INTERWEST PARTNERS VIII LP INTERWEST INVESTORS VIII L P INTERWEST INVESTORS Q VIII LP InterWest Management Partners VIII, LLC Ehrlich Christopher B ORONSKY ARNOLD L GIANOS PHILIP T Bowsher Stephen C Rosch Thomas L (10% owner)	26,339	$0	0 (Indirect)	View
2004-10-13 Purchase	2004-10-13 6:09 pm	N/A N/A	INTRALASE CORP	ILSE	Holmes W Stephen INTERWEST PARTNERS VIII LP INTERWEST INVESTORS VIII L P INTERWEST INVESTORS Q VIII LP InterWest Management Partners VIII, LLC Ehrlich Christopher B ORONSKY ARNOLD L GIANOS PHILIP T Bowsher Stephen C Rosch Thomas L (10% owner)	7,348	$0	0 (Indirect)	View
2004-10-13 Purchase	2004-10-13 6:09 pm	N/A N/A	INTRALASE CORP	ILSE	Holmes W Stephen INTERWEST PARTNERS VIII LP INTERWEST INVESTORS VIII L P INTERWEST INVESTORS Q VIII LP InterWest Management Partners VIII, LLC Ehrlich Christopher B ORONSKY ARNOLD L GIANOS PHILIP T Bowsher Stephen C Rosch Thomas L (10% owner)	838,421	$0	0 (Indirect)	View
2004-10-13 Purchase	2004-10-13 6:09 pm	N/A N/A	INTRALASE CORP	ILSE	Holmes W Stephen INTERWEST PARTNERS VIII LP INTERWEST INVESTORS VIII L P INTERWEST INVESTORS Q VIII LP InterWest Management Partners VIII, LLC Ehrlich Christopher B ORONSKY ARNOLD L GIANOS PHILIP T Bowsher Stephen C Rosch Thomas L (10% owner)	24,000	$0	0 (Indirect)	View
2004-10-13 Purchase	2004-10-13 6:09 pm	N/A N/A	INTRALASE CORP	ILSE	Holmes W Stephen INTERWEST PARTNERS VIII LP INTERWEST INVESTORS VIII L P INTERWEST INVESTORS Q VIII LP InterWest Management Partners VIII, LLC Ehrlich Christopher B ORONSKY ARNOLD L GIANOS PHILIP T Bowsher Stephen C Rosch Thomas L (10% owner)	7,144	$0	0 (Indirect)	View
2004-06-21 Purchase	2004-06-23 9:06 pm	N/A N/A	METABASIS THERAPEUTICS INC	MBRX	Holmes W Stephen INTERWEST PARTNERS VII L P INTERWEST MANAGEMENT PARTNERS VII LLC InterWest Investors VII, LP Bowsher Stephen C CASH HARVEY B GIANOS PHILIP T HEDRICK W SCOTT Kliman Gilbert H ORONSKY ARNOLD L (10% owner)	782,411	$0	0 (Direct)	View
2004-06-21 Purchase	2004-06-23 9:06 pm	N/A N/A	METABASIS THERAPEUTICS INC	MBRX	Holmes W Stephen INTERWEST PARTNERS VII L P INTERWEST MANAGEMENT PARTNERS VII LLC InterWest Investors VII, LP Bowsher Stephen C CASH HARVEY B GIANOS PHILIP T HEDRICK W SCOTT Kliman Gilbert H ORONSKY ARNOLD L (10% owner)	37,468	$0	0 (Indirect)	View
2004-06-21 Purchase	2004-06-23 9:06 pm	N/A N/A	METABASIS THERAPEUTICS INC	MBRX	Holmes W Stephen INTERWEST PARTNERS VII L P INTERWEST MANAGEMENT PARTNERS VII LLC InterWest Investors VII, LP Bowsher Stephen C CASH HARVEY B GIANOS PHILIP T HEDRICK W SCOTT Kliman Gilbert H ORONSKY ARNOLD L (10% owner)	539,815	$0	0 (Direct)	View
2004-06-21 Purchase	2004-06-23 9:06 pm	N/A N/A	METABASIS THERAPEUTICS INC	MBRX	Holmes W Stephen INTERWEST PARTNERS VII L P INTERWEST MANAGEMENT PARTNERS VII LLC InterWest Investors VII, LP Bowsher Stephen C CASH HARVEY B GIANOS PHILIP T HEDRICK W SCOTT Kliman Gilbert H ORONSKY ARNOLD L (10% owner)	25,850	$0	0 (Indirect)	View
2004-06-21 Purchase	2004-06-23 9:06 pm	N/A N/A	METABASIS THERAPEUTICS INC	MBRX	Holmes W Stephen INTERWEST PARTNERS VII L P INTERWEST MANAGEMENT PARTNERS VII LLC InterWest Investors VII, LP Bowsher Stephen C CASH HARVEY B GIANOS PHILIP T HEDRICK W SCOTT Kliman Gilbert H ORONSKY ARNOLD L (10% owner)	657,044	$0	0 (Direct)	View
2004-06-21 Purchase	2004-06-23 9:06 pm	N/A N/A	METABASIS THERAPEUTICS INC	MBRX	Holmes W Stephen INTERWEST PARTNERS VII L P INTERWEST MANAGEMENT PARTNERS VII LLC InterWest Investors VII, LP Bowsher Stephen C CASH HARVEY B GIANOS PHILIP T HEDRICK W SCOTT Kliman Gilbert H ORONSKY ARNOLD L (10% owner)	31,464	$0	0 (Indirect)	View