Sec Form 4 Filing - HIGGINS JOHN L @ BIO-TECHNE Corp - 2023-04-28

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person HIGGINS JOHN L 2. Issuer Name and Ticker or Trading Symbol BIO-TECHNE Corp [ TECH] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) X __ Director _____ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) 614 MCKINLEY PLACE NE 3. Date of Earliest Transaction (MM/DD/YY) 04/28/2023 (Street) MINNEAPOLIS, MN55413 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 04/28/2023 M 16,000 A $ 21.85 39,360 D Common Stock 04/28/2023 F 4,377 D $ 79.88 34,983 D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Stock Options (Right to Buy) $ 21.85 04/28/2023 M 16,000 10/31/2013 10/30/2023 Common Stock 16,000 $ 0 0 D Stock Options (Right to Buy) $ 22.95 10/30/2014 10/30/2024 Common Stock 16,000 16,000 D Stock Options (Right to Buy) $ 21.84 10/29/2016 10/28/2025 Common Stock 17,040 17,040 D Stock Options (Right to Buy) $ 25.3 10/26/2017 10/26/2026 Common Stock 15,940 15,940 D Stock Options (Right to Buy) $ 31.26 10/25/2018 10/27/2027 Common Stock 12,500 12,500 D Stock Options (Right to Buy) $ 44.96 10/24/2019 10/25/2028 Common Stock 7,592 7,592 D Stock Options (Right to Buy) $ 50.41 10/24/2020 10/24/2029 Common Stock 8,044 8,044 D Stock Options (Right to Buy) $ 63.92 10/28/2021 10/29/2030 Common Stock 6,028 6,028 D Stock Options (Right to Buy) $ 128.81 10/27/2022 10/28/2031 Common Stock 2,532 2,532 D Stock Options (Right to Buy) $ 73.94 ( 1 ) 10/27/2032 Common Stock 3,460 3,460 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other HIGGINS JOHN L 614 MCKINLEY PLACE NE MINNEAPOLIS, MN55413 X Signatures /s/ Andrew Nick as Attorney-in-Fact for John L. Higgins pursuant to Power of Attorney previously filed 05/02/2023 Signature of Reporting Person Date

Explanation of Responses:

( 1 )The option vests on the earlier of the one year anniversary of the grant date (10/27/22) or the date of Bio-Techne's 2023 annual meeting of shareholders.

Remarks: On November 28, 2022, the Company completed a four-for-one stock split. All common stock amounts and exercise prices in the filing relating to securities acquired prior to November 28, 2022 have been adjusted to reflect the four-for-one stock split.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

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