Sec Form 3/A Filing - THERMO FISHER SCIENTIFIC INC. @ Science 37 Holdings, Inc. - 2021-12-08

FORM 3/A Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person THERMO FISHER SCIENTIFIC INC. 2. Issuer Name and Ticker or Trading Symbol Science 37 Holdings, Inc. [ SNCE] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director X __ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) 168 THIRD AVENUE 3. Date of Earliest Transaction (MM/DD/YY) 12/08/2021 (Street) WALTHAM, MA02451 4. If Amendment, Date Original Filed (MM/DD/YY) 12/20/2021 6. Individual or Joint/Group Filing (Check Applicable Line) _____ Form filed by One Reporting Person __ X __ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 17,379,797 I ( 1 ) ( 2 ) ( 3 ) See footnote ( 1 ) ( 2 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other THERMO FISHER SCIENTIFIC INC. 168 THIRD AVENUE WALTHAM, MA02451 X Thermo Fisher Scientific Powder US Holdings Corp. 168 THIRD AVENUE WALTHAM, MA02451 X Thermo Fisher Scientific Powder US Holdings Ltd 168 THIRD AVENUE WALTHAM, MA02451 X Thermo Fisher Scientific Powder Holdings IV 168 THIRD AVENUE WALTHAM, MA02451 X Thermo Fisher Scientific Powder Holdings III 168 THIRD AVENUE WALTHAM, MA02451 X Thermo Fisher Scientific Powder Holdings II 168 THIRD AVENUE WALTHAM, MA02451 X Thermo Fisher Scientific Powder Holdings I 168 THIRD AVENUE WALTHAM, MA02451 X Spectra-Physics Holdings USA, LLC 168 THIRD AVENUE WALTHAM, MA02451 X Fisher Scientific Worldwide Inc. 168 THIRD AVENUE WALTHAM, MA02451 X Fisher Scientific International LLC 168 THIRD AVENUE WALTHAM, MA02451 X Signatures Thermo Fisher Scientific Inc.,/s/ Michael Boxer,Senior Vice President and General Counsel 03/14/2024 Signature of Reporting Person Date Thermo Fisher Scientific Powder US Holdings Corp.,/s/ Anthony H. Smith,President 03/14/2024 Signature of Reporting Person Date Thermo Fisher Scientific Powder US Holdings Ltd,/s/ Anthony H. Smith,Director 03/14/2024 Signature of Reporting Person Date Thermo Fisher Scientific Powder Holdings IV Ltd,/s/ Anthony H. Smith,Director 03/14/2024 Signature of Reporting Person Date Thermo Fisher Scientific Powder Holdings III Ltd,/s/ Anthony H. Smith,Director 03/14/2024 Signature of Reporting Person Date Thermo Fisher Scientific Powder Holdings II Ltd,/s/ Anthony H. Smith,Director 03/14/2024 Signature of Reporting Person Date Thermo Fisher Scientific Powder Holdings I Ltd,/s/ Anthony H. Smith,Director 03/14/2024 Signature of Reporting Person Date Spectra-Physics Holdings USA, LLC,/s/ Anthony H. Smith,Treasurer and Assistant Secretary 03/14/2024 Signature of Reporting Person Date Fisher Scientific Worldwide Inc.,/s/ Anthony H. Smith,Treasurer and Assistant Secretary 03/14/2024 Signature of Reporting Person Date Fisher Scientific International LLC,/s/ Anthony H. Smith,Vice President and Treasurer 03/14/2024 Signature of Reporting Person Date

Explanation of Responses:

( 1 )These shares of common stock, par value $0.0001 per share, of Science 37 Holdings, Inc. are held of record by Pharmaceutical Product Development, LLC ("Pharma LLC"). Wildcat Acquisition Holdings (UK) Limited ("Wildcat") is the sole member of Pharma LLC; Jaguar Holding Company II ("Jaguar II") is the sole shareholder of Wildcat; Jaguar Holding Company I, LLC ("Jaguar I") is the sole shareholder of Jaguar II; Eagle Holding Company II, LLC ("Eagle II") is the sole member of Jaguar I; PPD, Inc. ("PPD") is the sole member of Eagle II; Thermo Fisher Scientific Powder US Holdings Corp. ("Powder Holdings") is the sole shareholder of PPD; Thermo Fisher Scientific Powder US Holdings Ltd ("US Holdings") is the sole shareholder of Powder Holdings; Thermo Fisher Scientific Powder Holdings II Ltd ("Powder Holdings II") is the sole shareholder of US Holdings. ( 2 )Thermo Fisher Scientific Powder Holdings IV Ltd ("Powder Holdings IV") and Thermo Fisher Scientific Powder Holdings I Ltd ("Powder Holdings I") are the 11.76% shareholder and the 88.24% shareholder, respectively, of Powder Holdings II; Thermo Fisher Scientific Powder Holdings III Ltd ("Powder Holdings III") is the sole shareholder of Powder Holdings IV; Spectra-Physics Holdings USA, LLC ("Spectra-Physics") is the sole shareholder of Powder Holdings I; Fisher Scientific Worldwide Inc. ("Worldwide") is the sole member of Spectra-Physics; Fisher Scientific International LLC ("Scientific International") is the sole shareholder of Worldwide; Scientific International is the sole shareholder of Powder Holdings III; and Thermo Fisher Scientific Inc. is the sole member of Scientific International. By virtue of such relationships, each of the reporting persons may be deemed to have beneficial ownership over such shares of common stock. ( 3 )This report on Form 3 is jointly filed by the reporting persons. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), except to the extent of its pecuniary interest therein. Disclosure of the information required by this Form was made by Pharma LLC, Wildcat, Jaguar II, Jaguar I, Eagle II and PPD pursuant to PPD, Inc.'s Form 3 filed on October 18, 2021 and Form 3/A filed on November 8, 2021.

Remarks: This Form 3/A amends and restates the original Form 3 filed by the reporting persons on December 20, 2021, as amended by the reporting persons on December 27, 2021. This amendment is being filed to include Thermo Fisher Scientific Powder US Holdings Ltd, Thermo Fisher Scientific Powder Holdings I Ltd, Thermo Fisher Scientific Powder Holdings II Ltd, Thermo Fisher Scientific Powder Holdings III Ltd, Thermo Fisher Scientific Powder Holdings IV Ltd, Spectra-Physics Holdings USA LLC, Fisher Scientific Worldwide Inc. and Fisher Scientific International LLC as reporting persons.

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