Sec Form 4 Filing - Versant Venture Capital VI, L.P. @ Oyster Point Pharma, Inc. - 2021-03-26

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL OMB Number: 3235-0287 Expires: November 30, 2011 Estimated average burden hours per response... 0.5

1. Name and Address of Reporting Person Versant Venture Capital VI, L.P. 2. Issuer Name and Ticker or Trading Symbol Oyster Point Pharma, Inc. [ OYST] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director X __ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) ONE SANSOME STREET, SUITE 3630 3. Date of Earliest Transaction (MM/DD/YY) 03/26/2021 (Street) SAN FRANCISCO, CA94104 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) _____ Form filed by One Reporting Person __ X __ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 03/26/2021 J( 1 ) 320,368 D $ 0 1,681,930 I See Footnotes ( 2 ) Common Stock 03/26/2021 J( 3 ) 82,491 A $ 0 82,491 I See Footnotes ( 4 ) Common Stock 03/26/2021 J( 5 ) 82,491 D $ 0 0 I See Footnotes ( 4 ) Common Stock 03/26/2021 J( 6 ) 1,990 D $ 0 10,448 I See Footnotes ( 7 ) Common Stock 2,236,888 D ( 8 ) Common Stock 1,003,658 I See Footnotes ( 9 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise P rice of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Versant Venture Capital VI, L.P. ONE SANSOME STREET SUITE 3630 SAN FRANCISCO, CA94104 X Versant Ventures VI GP, L.P. ONE SANSOME STREET SUITE 3630 SAN FRANCISCO, CA94104 X Versant Ventures VI GP-GP, LLC ONE SANSOME STREET SUITE 3630 SAN FRANCISCO, CA94104 X Versant Vantage I, L.P. ONE SANSOME STREET SUITE 3630 SAN FRANCISCO, CA94104 X Versant Vantage I GP, L.P. ONE SANSOME STREET SUITE 3630 SAN FRANCISCO, CA94104 X Versant Vantage I GP-GP, LLC ONE SANSOME STREET SUITE 3630 SAN FRANCISCO, CA94104 X Versant Ventures IV, LLC ONE SANSOME STREET SUITE 3630 SAN FRANCISCO, CA94104 X Versant Venture Capital IV, L.P. ONE SANSOME STREET SUITE 3630 SAN FRANCISCO, CA94104 X Versant Side Fund IV, L.P. ONE SANSOME STREET SUITE 3630 SAN FRANCISCO, CA94104 X Signatures /s/ Versant Venture Capital VI, L.P. By: Versant Ventures VI GP, L.P. Its: General Partner By: Versant Ventures VI GP-GP, LLC Its: General Partner By: Robin L. Praeger Its: Managing Director 03/30/2021 Signature of Reporting Person Date /s/ Versant Ventures VI GP, L.P. By: Versant Ventures VI GP-GP, LLC Its: General Partner By: Robin L. Praeger Its: Managing Director 03/30/2021 Signature of Reporting Person Date /s/ Versant Ventures VI GP-GP, LLC By: Robin L. Praeger Its: Managing Director 03/30/2021 Signature of Reporting Person Date /s/ Versant Vantage I, L.P. By: Versant Vantage I GP, L.P. Its: General Partner By: Versant Vantage I GP-GP, LLC Its: General Partner By: Robin L. Praeger Its: Managing Director 03/30/2021 Signature of Reporting Person Date /s/ Versant Vantage I GP, L.P. By: Versant Vantage I GP-GP, LLC Its: General Partner By: Robin L. Praeger Its: Managing Director 03/30/2021 Signature of Reporting Person Date /s/ Versant Vantage I GP-GP, LLC By: Robin L. Praeger Its: Managing Director 03/30/2021 Signature of Reporting Person Date /s/ Versant Ventures IV, LLC By: Robin L. Praeger Its: Managing Director 03/30/2021 Signature of Reporting Person Date /s/ Versant Venture Capital IV, L.P. By: Versant Ventures IV, LLC Its: General Partner By: Robin L. Praeger Its: Managing Director 03/30/2021 Signature of Reporting Person Date /s/ Versant Side Fund IV, L.P. By: Versant Ventures IV, LLC Its: General Partner By: Robin L. Praeger Its: Managing Director 03/30/2021 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Represents a pro-rata distribution, and not a purchase or sale, without additional consideration by Versant Venture Capital IV, L.P. ("Versant IV") to its partners. ( 2 )Shares held by Versant IV. Versant Ventures IV, LLC ("Versant Ventures IV") is the sole general partner of Versant IV. William J. Link, a member of the Issuer's board of directors, is a managing member of Versant Ventures IV and may be deemed to share voting and dispositive power over the shares held by Versant IV. Each of Versant Ventures IV and William J. Link disclaims beneficial ownership of the shares held by Versant IV, except to the extent of their respective pecuniary interests therein. William J. Link is a director of the Issuer and, accordingly, files separate Section 16 reports. ( 3 )Represents a change in the form of ownership of Versant Ventures IV by virtue of the receipt of shares in the pro-rata in-kind distribution of common stock of the Issuer for no consideration by Versant IV. ( 4 )Shares held by Versant Ventures IV. William J. Link, a member of the Issuer's board of directors, is a managing member of Versant Ventures IV and may be deemed to share voting and dispositive power over the shares held by Versant Ventures IV. William J. Link disclaims beneficial ownership of the shares held by Versant Ventures IV, except to the extent of hi s pecuniary interests therein. William J. Link is a director of the Issuer and, accordingly files separate Section 16 reports. ( 5 )Represents a pro-rata distribution, and not a purchase or sale, without additional consideration by Versant Ventures IV, to its members. ( 6 )Represents a pro-rata distribution, and not a purchase or sale, without additional consideration by Versant Side Fund IV, L.P. ("Versant Side Fund IV") to its partners. ( 7 )Shares held by Versant Side Fund IV. Versant Ventures IV is the sole general partner of Versant Side Fund IV. William J. Link, a member of the Issuer's board of directors, is a managing member of Versant Ventures IV and may be deemed to share voting and dispositive power over the shares held by Versant Side Fund IV. Each of Versant Ventures IV and William J. Link disclaims beneficial ownership of the shares held by Versant Side Fund IV, except to the extent of their respective pecuniary interests therein. William J. Link is a director of the Issuer and, accordingly, files separate Section 16 reports. ( 8 )Shares held by Versant Venture Capital VI, L.P. ("Versant VI"). Versant Ventures VI GP-GP, LLC ("Versant Ventures VI GP-GP") is the sole general partner of Versant Ventures VI GP, L.P. ("Versant Ventures VI GP") and Versant Ventures VI GP is the sole general partner of Versant VI. Clare Ozawa, a member of the Issuer's board of directors, is a managing member of Versant Ventures VI GP-GP and may be deemed to share voting and dispositive power over the shares held by Versant VI. Each of Versant Ventures VI GP-GP, Versant Ventures VI GP and Clare Ozawa disclaims beneficial ownership of the shares held by Versant VI, except to the extent of their respective pecuniary interests therein. Clare Ozawa is a director of the Issuer and, accordingly files separate Section 16 reports. ( 9 )Shares held by Versant Vantage I, L.P. ("Versant Vantage"). Versant Vantage I GP-GP, LLC ("Versant Vantage I GP-GP") is the sole general partner of Versant Vantage I GP, L.P. ("Versant Vantage I GP") and Versant Vantage I GP is the sole general Partner of Versant Vantage. Clare Ozawa, a member of the Issuer's board of directors, is a managing member of Versant Vantage I GP-GP and may be deemed to share voting and dispositive power over the shares held by Versant Vantage. Each of Versant Vantage I GP-GP, Versant Vantage I GP, and Clare Ozawa disclaims beneficial ownership of the shares held by Versant Vantage, except to the extent of their respective pecuniary interests therein. Clare Ozawa is a director of the Issuer and, accordingly files separate Section 16 reports.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.