Sec Form 4 Filing - JANNEY DANIEL @ Neothetics, Inc. - 2014-11-25

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person JANNEY DANIEL 2. Issuer Name and Ticker or Trading Symbol Neothetics, Inc. [ NEOT] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) X __ Director X __ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) ONE EMBARCADERO CENTER, SUITE 3700 3. Date of Earliest Transaction (MM/DD/YY) 11/25/2014 (Street) SAN FRANCISCO, CA94111 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) _____ Form filed by One Reporting Person __ X __ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 11/25/2014 C 122,951 A 126,885 I Alta Partners VIII, LP ( 2 ) Common Stock 11/25/2014 C 1,161,939 A 1,288,824 I Alta Partners VIII, LP ( 2 ) Common Stock 11/25/2014 C 476,845 A 1,765,669 I Alta Partners VIII, LP ( 2 ) Common Stock 11/25/2014 C 735,912 A 2,501,581 I Alta Partners VIII, LP ( 2 ) Common Stock 11/25/2014 X 93,676 ( 3 ) A $ 11.29 2,595,257 I Alta Partners VIII, LP ( 2 ) Common Stock 11/25/2014 S 57,143 D $ 14 2,538,114 I Alta Partners VIII, LP ( 2 ) Common Stock 11/25/2014 X 115,925 ( 3 ) A $ 8.54 2,654,039 I Alta Partners VIII, LP ( 2 ) Common Stock 11/25/2014 S 70,714 D $ 14 2,583,325 I Alta Partners VIII, LP ( 2 ) Common Stock 11/25/2014 X 35,128 ( 3 ) A $ 8.54 2,618,453 I Alta Partners VIII, LP ( 2 ) Common Stock 11/25/2014 S 21,429 D $ 14 2,597,024 I Alta Partners VIII, LP ( 2 ) Common Stock 11/25/2014 P 70,000 A $ 14 2,667,024 I Alta Partners VIII, LP ( 2 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Seires A Preferred Stock ( 1 ) 11/25/2014 C 750,000 ( 1 ) ( 1 ) Common Stock 750,000 ( 1 ) 0 I Alta Parnters VIII, LP ( 2 ) Series B Preferred Stock ( 1 ) 11/25/2014 C 6,216,215 ( 1 ) ( 1 ) Common Stock 6,216,215 ( 1 ) 0 I Alta Parnters VIII, LP ( 2 ) Series B-2 Preferred Stock ( 1 ) 11/25/2014 C 2,201,220 ( 1 ) ( 1 ) Common Stock 2,201,220 ( 1 ) 0 I Alta Parnters VIII, LP ( 2 ) Series C Preferred Stock ( 1 ) 11/25/2014 C 4,489,065 ( 1 ) ( 1 ) Common Stock 4,489,065 ( 1 ) 0 I Alta Parnters VIII, LP ( 2 ) Warrant $ 1.85 11/25/2014 X 432,432 09/30/2011 09/30/2018 Series B-2 Preferred Stock 432,432 $ 1.85 0 I Alta Parnters VIII, LP ( 2 ) Warrant $ 1.4 11/25/2014 X 707,142 12/12/2011 12/01/2018 Series C Prefered Stock 707,142 $ 1.4 0 I Alta Parnters VIII, LP ( 2 ) Warrant $ 1.4 11/25/2014 X 214,285 07/25/2012 07/25/2019 Series C Preferred Stock 214,285 $ 1.4 0 I Alta Parnters VIII, LP ( 2 )

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other JANNEY DANIEL ONE EMBARCADERO CENTER SUITE 3700 SAN FRANCISCO, CA94111 X X Alta Partners VIII, L.P. ONE EMBARCADERO CENTER SUITE 3700 SAN FRANCISCO, CA94111 X Alta Partners Management VIII, LLC ONE EMBARCADERO CENTER SUITE 3700 SAN FRANCISCO, CA94111 X CHAMPSI FARAH ONE EMBARCADERO CENTER SUITE 3700 SAN FRANCISCO, CA94111 X NOHRA GUY P ONE EMBARCADERO CENTER SUITE 3700 SAN FRANCISCO, CA94111 X Signatures /s/ George Mahaffey, Attorney-in-fact 11/25/2014 Signature of Reporting Person Date George Mahaffey, Attorney-in-fact 11/25/2014 Signature of Reporting Person Date George Mahaffey, Attorney-in-fact 11/25/2014 Signature of Reporting Person Date George Mahaffey, Attorney-in-fact 11/25/2014 Signature of Reporting Person Date George Mahaffey, Attorney-in-fact 11/25/2014 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Immediately prior to but contingent upon the closing of the initial public offering of the Issuer's Common Stock, all outstanding shares of Preferred Stock will be automatically converted, for no additional consideration, into shares of the Issuer's Common Stock. The Preferred Stock will convert pursuant to the applicable conversion ratio, as listed in the Amended and Restated Certificate of Incorporation of the Issuer, and reflect a 6.1-for-1 stock split of the Issuer's Common Stock which occurred on November 7, 2014. ( 2 )The securities are held by Alta Partners VII, L.P. ("APVIII"). Alta Partners Manegment VIII, LLC ("APMVIII") is the general partner of APVIII. Guy Nohra, Daniel Janney and Farah Champsi are managing directors of APMVIII and exercise shared voting and investment power with respect to the shares owned by APVIII. Each of the reporting persons disclaims beneficial ownership of such securities, except to the extent of his, her or its proportionate pecuniary interest therein. ( 3 )Represents shares as converted to Common Stock pursuant to the applicable conversion ratio, as listed in the Amended and Restated Certificate of Incorporation of the Issuer, and the 6.1-for-1 stock split of the Issuer's Common Stock which occurred on November 7, 2014.

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