Sec Form 4 Filing - Boxer Capital, LLC @ Mirati Therapeutics, Inc. - 2015-09-16

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Boxer Capital, LLC 2. Issuer Name and Ticker or Trading Symbol Mirati Therapeutics, Inc. [ MRTX] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director X __ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) 440 STEVENS AVE, SUITE 100, 3. Date of Earliest Transaction (MM/DD/YY) 09/16/2015 (Street) SOLANA BEACH, CA92075 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) _____ Form filed by One Reporting Person __ X __ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 09/16/2015 P 22,500 A $ 45 2,023,232 D ( 1 ) Common Stock 09/16/2015 P 22,500 A $ 45 522,500 D ( 2 ) Common Stock 429,340 D ( 3 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Warrant (right to purchase) $ 6.74 09/17/2015 S 1 ( 4 ) 04/04/2016 Common Stock 272,882 $ 10,167,583.32 0 D ( 1 ) Warrant (right to purchase) $ 6.74 09/17/2015 S 1 ( 4 ) 04/04/2016 Common Stock 40,874 $ 1,522,965.24 0 D ( 3 )

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Boxer Capital, LLC 440 STEVENS AVE, SUITE 100 SOLANA BEACH, CA92075 X Boxer Asset Management Inc. C/O CAY HOUSE P.O. BOX N-7776 E.P. TAYLOR DRIVE LYFORD CAY NEW PROVIDENCE, C5 X LEWIS JOSEPH C/O CAY HOUSE P.O. BOX N-7776 E.P. TAYLOR DRIVE LYFORD CAY NEW PROVIDENCE, C5 X Berkley Capital Management Ltd. C/O CAY HOUSE P.O. BOX N-7776 E.P. TAYLOR DRIVE LYFORD CAY NEW PROVIDENCE, C5 X MVA Investors, LLC 440 STEVENS AVE, SUITE 100 SOLANA BEACH, CA92075 X Signatures Boxer Capital, LLC, By: /s/ Aaron Davis 09/18/2015 Signature of Reporting Person Date Boxer Asset Management, Inc., By: /s/ Jefferson Voss 09/18/2015 Signature of Reporting Person Date MVA Investors, LLC, By: /s/ Aaron Davis 09/18/2015 Signature of Reporting Person Date Joe Lewis, By: /s/ Joe Lewis 09/18/2015 Signature of Reporting Person Date Berkley Capital Management Ltd., By: /s/ Jefferson Voss 09/18/2015 Signature of Reporting Person Date

Explanation of Responses:

( 1 )These securities are owned directly by Boxer Capital, LLC ("Boxer Capital"), which may be deemed to be a member of a "group" for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended, consisting of (i) Boxer Capital, (ii) Boxer Asset Management Inc. ("Boxer Management"), (iii) MVA Investors, LLC ("MVA Investors"), (iv) Berkley Capital Management Ltd. ("Berkley Capital"), and (v) Joe Lewis (collectively, the "Boxer Group"), and indirectly by Boxer Management and Joe Lewis, by virtue of their ownership in Boxer Capital. ( 2 )These securities are owned directly by Berkley Capital, and indirectly by Joe Lewis. Joe Lewis is the sole indirect owner of and controls Berkley Capital. ( 3 )These securities are owned directly and solely by MVA Investors, which has sole voting and dispositive power with respect to these securities. Each member of the Boxer Group other than MVA Investors disclaims beneficial ownership of these securities to the extent it or he does not have a pecuniary interest therein. ( 4 )The warrants are not exercisable to the extent that, following exercise of such warrants, the warrant holder would hold more than 19.9% of the issuer's common stock.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

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