Sec Form 4 Filing - ENRIGHT PATRICK G @ Esperion Therapeutics, Inc. - 2014-11-17

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person ENRIGHT PATRICK G 2. Issuer Name and Ticker or Trading Symbol Esperion Therapeutics, Inc. [ ESPR] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) X __ Director X __ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) C/O LONGITUDE CAPITAL PARTNERS, LLC, 800 EL CAMINO REAL, SUITE 220 3. Date of Earliest Transaction (MM/DD/YY) 11/17/2014 (Street) MENLO PARK, CA94025 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 11/17/2014 S 200,591 D $ 32.0115 ( 1 ) 1,683,178 I By LVP ( 11 ) Common Stock 11/17/2014 S 136,148 D $ 32.9339 ( 2 ) 1,547,030 I By LVP ( 11 ) Common Stock 11/17/2014 S 135,816 D $ 33.7897 ( 3 ) 1,411,214 I By LVP ( 11 ) Common Stock 11/17/2014 S 4,021 D $ 32.0115 ( 4 ) 33,736 I By LCA ( 11 ) Common Stock 11/17/2014 S 2,728 D $ 32.9339 ( 5 ) 31,008 I By LCA ( 11 ) Common Stock 11/17/2014 S 2,722 D $ 33.7896 ( 6 ) 28,286 I By LCA ( 11 ) Common Stock 11/18/2014 S 4,592 D $ 31.5644 ( 7 ) 1,406,622 I By LVP ( 11 ) Common Stock 11/18/2014 S 412 D $ 32.1377 ( 8 ) 1,406,210 I By LVP ( 11 ) Common Stock 11/18/2014 S 92 D $ 31.5666 ( 9 ) 28,194 I By LCA ( 11 ) Common Stock 11/18/2014 S 8 D $ 32.1313 ( 10 ) 28,186 I By LCA ( 11 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other ENRIGHT PATRICK G C/O LONGITUDE CAPITAL PARTNERS, LLC 800 EL CAMINO REAL, SUITE 220 MENLO PARK, CA94025 X X Signatures /s/ Patrick G. Enright 11/19/2014 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Reflects sales of Common Stock of the Issuer executed in multiple transactions at prices ranging from $31.52 to $32.51. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected. ( 2 )Reflects sales of Common Stock of the Issuer executed in multiple transactions at prices ranging from $32.52 to $33.5150. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected. ( 3 )Reflects sales of Common Stock of the Issuer executed in multiple transactions at prices ranging from $33.52 to $34.42. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected. ( 4 )Reflects sales of Common Stock of the Issuer executed in multiple transactions at prices ranging from $31.52 to $32.51. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected. ( 5 )Reflects sales of Common Stock of the Issuer executed in multiple transactions at prices ranging from $32.52 to $33.5150. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected. ( 6 )Reflects sales of Common Stock of the Issuer executed in multiple transactions at prices ranging from $33.52 to $34.42. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected. ( 7 )Reflects sales of Common Stock of the Issuer executed in multiple transactions at prices ranging from $31.08 to $32.01. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected. ( 8 )Reflects sales of Common Stock of the Issuer executed in multiple transactions at prices ranging from $32.09 to $32.26. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected. ( 9 )Reflects sales of Common Stock of the Issuer executed in multiple transactions at prices ranging from $31.08 to $32.01. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected. ( 10 )Reflects sales of Common Stock of the Issuer executed in multiple transactions at prices ranging from $32.09 to $32.26. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected. ( 11 )Mr. Enright is a managing member of Longitude Capital Partners, LLC ("Longitude Capital"). Longitude Capital, as the general partner of each of Longitude Venture Partners, L.P. ("LVP") and Longitude Capital Associates, L.P. ("LCA"), has the power to vote and dispose of securities held by each of them. As such, Mr. Enright may be deemed to beneficially own the shares held by LVP and LCA. Mr. Enright disclaims beneficial ownership of the securities of the Issuer held by LVP and LCA except to the extent of his pecuniary interest therein.

Remarks: All of the sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

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