Sec Form 3 Filing - Astle Christopher @ Zymeworks Inc. - 2022-02-24

FORM 3 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Astle Christopher 2. Issuer Name and Ticker or Trading Symbol Zymeworks Inc. [ ZYME] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner X __ Officer (give title below) _____ Other (specify below) SVP & Chief Financial Officer (Last) (First) (Middle) C/O ZYMEWORKS INC., 114 EAST 4TH AVENUE, SUITE 800 3. Date of Earliest Transaction (MM/DD/YY) 02/24/2022 (Street) VANCOUVER, A1V5T 1G4 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Shares 670 D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Stock Option (Right to Buy) $ 29.8055( 2 ) ( 1 ) 05/16/2031 Common Shares 17,250 D Restricted Stock Unit ( 4 ) ( 3 ) ( 3 ) Common Shares 3,100 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Astle Christopher C/O ZYMEWORKS INC. 114 EAST 4TH AVENUE, SUITE 800 VANCOUVER, A1V5T 1G4 SVP & Chief Financial Officer Signatures /s/ Daniel Dex, Attorney-in-Fact 03/04/2022 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Stock options vest as follows: (i) 25% on May 17, 2022 (the first anniversary of grant date) and (ii) remainder in 36 equal monthly installments on last day of each month following first anniversary of grant date. ( 2 )The exercise price of the stock option was converted from CAD36.01 using the closing rate of exchange of the Bank of Canada on the date of grant. The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the date of exercise. ( 3 )The restricted stock units vest in two equal annual installments beginning on December 10, 2022. ( 4 )Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

Remarks: Exhibit List - Exhibit 24 - Power of Attorney

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

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