Sec Form 4 Filing - KIRK RANDAL J @ ZIOPHARM ONCOLOGY INC

Insider filing report for Changes in Beneficial Ownership

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FORM 4

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP
Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person

KIRK RANDAL J

2. Issuer Name and Ticker or Trading Symbol
ZIOPHARM ONCOLOGY INC [ ZIOP]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X __ Director	X __ 10% Owner
_____ Officer (give title below)	_____ Other (specify below)

(Last)

(First)

(Middle)

C/O THIRD SECURITY, LLC, 1881 GROVE AVENUE

3. Date of Earliest Transaction (MM/DD/YY)
06/04/2015

(Street)

RADFORD, VA24141

4. If Amendment, Date Original Filed (MM/DD/YY)

6. Individual or Joint/Group Filing (Check Applicable Line)
_____ Form filed by One Reporting Person
__ X __ Form filed by More than One Reporting Person

(City)

(State)

(Zip)

**Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned**
1.Title of Security (Instr. 3)	2. Transaction Date (MM/DD/YY)	2A. Deemed Execution Date, if any (MM/DD/YY)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
1.Title of Security (Instr. 3)	2. Transaction Date (MM/DD/YY)	2A. Deemed Execution Date, if any (MM/DD/YY)	Code	V	Amount	(A) or (D)	Price		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
Common Stock	06/04/2015		J^{( 1 )}		17,830,305 ^{( 1 )}	D		0	I	by Intrexon Corporation ^{( 2 )}
Common Stock	06/04/2015		J^{( 1 )}		3,479,006 ^{( 1 )}	A		3,479,006	I	by R.J. Kirk DOT ^{( 3 )}
Common Stock	06/04/2015		J^{( 1 )}		23,349 ^{( 1 )}	A		23,349	I	by JPK 2008 ^{( 3 )}
Common Stock	06/04/2015		J^{( 1 )}		23,504 ^{( 1 )}	A		23,504	I	by MGK 2008 ^{( 3 )}
Common Stock	06/04/2015		J^{( 1 )}		40,954 ^{( 1 )}	A		40,954	I	by ZSK 2008 ^{( 3 )}
Common Stock	06/04/2015		J^{( 1 )}		240 ^{( 1 )}	A		240	I	by Lotus ^{( 3 )}
Common Stock	06/04/2015		J^{( 1 )}		53,245 ^{( 1 )}	A		53,245	I	by Staff 2001 ^{( 3 )}
Common Stock	06/04/2015		J^{( 1 )}		9,537 ^{( 1 )}	A		9,537	I	by Sr. Staff ^{( 3 )}
Common Stock	06/04/2015		J^{( 1 )}		337,333 ^{( 1 )}	A		337,333	I	by JPK 2009 ^{( 3 )}
Common Stock	06/04/2015		J^{( 1 )}		358,386 ^{( 1 )}	A		358,386	I	by MGK 2009 ^{( 3 )}
Common Stock	06/04/2015		J^{( 1 )}		34,318 ^{( 1 )}	A		34,318	I	by ZSK 2009 ^{( 3 )}
Common Stock	06/04/2015		J^{( 1 )}		29,066 ^{( 1 )}	A		29,066	I	by ADC 2010 ^{( 3 )}
Common Stock	06/04/2015		J^{( 1 )}		154,181 ^{( 1 )}	A		154,181	I	by MGK 2011 ^{( 3 )}
Common Stock	06/04/2015		J^{( 1 )}		138,975 ^{( 1 )}	A		138,975	I	by JPK 2012 ^{( 3 )}
Common Stock	06/04/2015		J^{( 1 )}		61,262 ^{( 1 )}	A		61,262	I	by Kellie L. Banks LTT ^{( 3 )}
Common Stock	06/04/2015		J^{( 1 )}		1,013,146 ^{( 1 )}	A		2,359,608	I	by Kapital Joe ^{( 4 )}
Common Stock	06/04/2015		J^{( 1 )}		889,513 ^{( 1 )}	A		889,513	I	by Mascara Kaboom ^{( 4 )}
Common Stock	06/04/2015		J^{( 1 )}		395,791 ^{( 1 )}	A		395,791	I	by Senior Staff 2008 ^{( 4 )}
Common Stock	06/04/2015		J^{( 1 )}		222,680 ^{( 1 )}	A		222,680	I	by Staff 2010 ^{( 4 )}
Common Stock	06/04/2015		J^{( 1 )}		111,339 ^{( 1 )}	A		111,339	I	by Incentive 2010 ^{( 4 )}
Common Stock	06/04/2015		J^{( 1 )}		352,477 ^{( 1 )}	A		352,477	I	by Senior Staff 2007 ^{( 4 )}
Common Stock	06/04/2015		J^{( 1 )}		176,238 ^{( 1 )}	A		176,238	I	by Staff 2007 ^{( 4 )}
Common Stock	06/04/2015		J^{( 1 )}		58,746 ^{( 1 )}	A		58,746	I	by Incentive 2007 ^{( 4 )}
Common Stock	06/04/2015		J^{( 1 )}		173,111 ^{( 1 )}	A		173,111	I	by Staff 2009 ^{( 4 )}
Common Stock	06/04/2015		J^{( 1 )}		86,556 ^{( 1 )}	A		86,556	I	by Incentive 2009 ^{( 4 )}
Common Stock								95,648	D

**Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned**
( *e.g.* , puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (MM/DD/YY)	3A. Deemed Execution Date, if any (MM/DD/YY)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)		6. Date Exercisable and Expiration Date (MM/DD/YY)		7. Title and Amount of Underlying Securities (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

**Reporting Owners**
Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
KIRK RANDAL J C/O THIRD SECURITY, LLC 1881 GROVE AVENUE RADFORD, VA24141	X	X
INTREXON CORP C/O LEGAL DEPARTMENT 20374 SENECA MEADOWS PARKWAY GERMANTOWN, MD20876		X

**Signatures**
/s/ Randal J. Kirk, CEO of Intrexon Corporation		06/08/2015
Signature of Reporting Person		Date
/s/ Randal J. Kirk		06/08/2015
Signature of Reporting Person		Date

Explanation of Responses:

( 1 )Intrexon Corporation declared a dividend of shares of ZIOPHARM Oncology, Inc. common stock held by it to its holders of record as of June 4, 2015.
( 2 )Randal J. Kirk, directly and through certain affiliates, has voting and dispositive power over a majority of the outstanding capital stock of Intrexon Corporation. Mr. Kirk may therefore be deemed to have voting and dispositive power over the shares of the issuer owned by Intrexon Corporation. Shares held by Intrexon Corporation may be deemed to be indirectly beneficially owned (as defined under Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) by Mr. Kirk. Mr. Kirk disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein.
( 3 )Randal J. Kirk controls each of Randal J. Kirk Declaration of Trust ("R.J. Kirk DOT"), JPK 2008, LLC ("JPK 2008"), MGK 2008, LLC ("MGK 2008"), ZSK 2008, LLC ("ZSK 2008"), Lotus Capital (2000) Co., Inc. ("Lotus"), Third Security Staff 2001 LLC ("Staff 2001"), Third Security Senior Staff LLC ("Sr. Staff"), JPK 2009, LLC ("JPK 2009"), MGK 2009, LLC ("MGK 2009"), ZSK 2009, LLC ("ZSK 2009"), ADC 2010, LLC ("ADC 2010"), MGK 2011, LLC ("MGK 2011"), JPK 2012, LLC ("JPK 2012") and Kellie L. Banks (2009) Long Term Trust ("Kellie L. Banks LTT"). Shares held by these entities may be deemed to be beneficially owned (as defined under Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) by Mr. Kirk. Mr. Kirk disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein.
( 4 )Randal J. Kirk controls each of Kapital Joe, LLC ("Kapital Joe"), Mascara Kaboom, LLC ("Mascara Kaboom"), Third Security Senior Staff 2008 LLC ("Senior Staff 2008"), Third Security Staff 2010 LLC ("Staff 2010"), Third Security Incentive 2010 LLC ("Incentive 2010"), Third Security Senior Staff 2007 LLC ("Senior Staff 2007"), Third Security Staff 2007 LLC ("Staff 2007"), Third Security Incentive 2007 LLC ("Incentive 2007"), Third Security Staff 2009 LLC ("Staff 2009") and Third Security Incentive 2009 LLC ("Incentive 2009"). Shares held by these entities may be deemed to be beneficially owned (as defined under Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) by Mr. Kirk. Mr. Kirk disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

Sec Form 4 Filing - KIRK RANDAL J @ ZIOPHARM ONCOLOGY INC - 2015-06-04