Sec Form 13G Filing - SOFINNOVA VENTURE PARTNERS V LP filing for MOLECULAR TEMPLATES INC NE (MTEM) - 2006-02-14

Insider filing report for Changes in Beneficial Ownership

  • Schedule 13G & 13D forms are used to report a party's ownership of stock which exceeds 5% of a company's total stock issue.
  • Schedule 13G is a shorter version of Schedule 13D with fewer reporting requirements.
"Insiders might sell their shares for any number of reasons, but they buy them for only one: they think the price will rise"
- Peter Lynch
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  Schedule 13G


   INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1 (b),
         (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO 13d-2 (b)

                               (Amendment No. __)*


                         Threshold Pharmaceuticals, Inc.
- --------------------------------------------------------------------------------
                                (Name of Issuer)


                                  Common Stock
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)


                                    885807107
- --------------------------------------------------------------------------------
                                 (CUSIP Number)


                                December 31, 2005
- --------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)

Check the  appropriate box to designate the rule pursuant to which this Schedule
is filed:

         [ ]         Rule 13d-1(b)

         [ ]         Rule 13d-1(c)

         [X]         Rule 13d-1(d)

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).



                               Page 1 of 15 Pages
                       Exhibit Index Contained on Page 14






- ----------------------------------------------------------                     --------------------------------------
CUSIP NO. 12345A678                                               13 G                                Page  2 of 15
- ----------------------------------------------------------                     --------------------------------------

- ------------ ---------------------------------------------------------------------------------------------------------
                               
1            NAME OF REPORTING PERSONS
             I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (Entities Only).
             Sofinnova Venture Partners V, L.P. ("SVP V")

- ------------ ---------------------------------------------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
                                                                                    (a)              (b) X
- ------------ ---------------------------------------------------------------------------------------------------------
3            SEC USE ONLY

- ------------ ---------------------------------------------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION

             Delaware
- ------------ ---------------------------------------------------------------------------------------------------------

                                     5        SOLE VOTING POWER
             NUMBER OF                        3,281,905 shares, except that Sofinnova Management V, L.L.C. ("SM V")
              SHARES                          and Sofinnova Management V 2005 L.L.C. ("SMV 2005"), the general
           BENEFICIALLY                       partners of SVP V, may be deemed to have shared voting power, and
      OWNED BY EACH REPORTING                 Michael F. Powell ("Powell"), Alain L. Azan ("Azan") and James I.
              PERSON                          Healy, M.D., Ph.D. ("Healy"), the managing members of SM V and SMV
               WITH                           2005, may be deemed to have shared power to vote these shares.
                                     -------- ------------------------------------------------------------------------
                                     6        SHARED VOTING POWER
                                              See response to row 5.
                                     -------- ------------------------------------------------------------------------
                                     7        SOLE DISPOSITIVE POWER
                                              3,281,905 shares, except that SM V and SMV 2005, the general partners
                                              of SVP V, may be deemed to have shared dispositive power and Powell,
                                              Azan and Healy, the managing members of SM V and SMV 2005, may be
                                              deemed to have shared power to dispose of these shares.
                                     -------- ------------------------------------------------------------------------
                                     8        SHARED DISPOSITIVE POWER
                                              See response to row 7.
- ------------------------------------ -------- ------------------------------------------------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON                                                                       3,281,905
- ------------ ---------------------------------------------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES (See Instructions)                                                 [ ]
- ------------ ---------------------------------------------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
                                                                                                    8.8%
- ------------ ---------------------------------------------------------------------------------------------------------
12           TYPE OF REPORTING PERSON (See Instructions)
                                                                                                    PN
- ------------ ---------------------------------------------------------------------------------------------------------




- ----------------------------------------------------------                     --------------------------------------
CUSIP NO. 12345A678                                               13 G                                Page  3 of 15
- ----------------------------------------------------------                     --------------------------------------

- ------------ ---------------------------------------------------------------------------------------------------------
                               
1            NAME OF REPORTING PERSONS
             I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (Entities Only).
                      Sofinnova Venture Affiliates V, L.P. ("SVA V")

- ------------ ---------------------------------------------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
                                                                                    (a)              (b)  X
- ------------ ---------------------------------------------------------------------------------------------------------
3            SEC USE ONLY

- ------------ ---------------------------------------------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION

             Delaware
- ------------ ---------------------------------------------------------------------------------------------------------

                                     5        SOLE VOTING POWER
             NUMBER OF                        107,974 shares, except that SM V, the general partner of SVA V, may be
              SHARES                          deemed to have sole voting power, and Powell, Azan and Healy, the
           BENEFICIALLY                       managing members of SM V, may be deemed to have shared power to vote
      OWNED BY EACH REPORTING                 these shares.
              PERSON
               WITH
                                     -------- ------------------------------------------------------------------------
                                     6        SHARED VOTING POWER
                                              See response to row 5.
                                     -------- ------------------------------------------------------------------------
                                     7        SOLE DISPOSITIVE POWER
                                              107,974 shares, except that SM V, the general partner of SVA V, may be
                                              deemed to have sole dispositive power, and Powell, Azan and Healy, the
                                              managing members of SM V, may be deemed to have shared power to
                                              dispose of these shares.
                                     -------- ------------------------------------------------------------------------
                                     8        SHARED DISPOSITIVE POWER
                                              See response to row 7.
- ------------------------------------ -------- ------------------------------------------------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON                                                                       107,974
- ------------ ---------------------------------------------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES (See Instructions)                                               [ ]
- ------------ ---------------------------------------------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
                                                                                                    0.3%
- ------------ ---------------------------------------------------------------------------------------------------------
12           TYPE OF REPORTING PERSON (See Instructions)
                                                                                                    PN
- ------------ ---------------------------------------------------------------------------------------------------------




- ----------------------------------------------------------                     --------------------------------------
CUSIP NO. 12345A678                                               13 G                                Page  4 of 15
- ----------------------------------------------------------                     --------------------------------------

- ------------ ---------------------------------------------------------------------------------------------------------
                               
1            NAME OF REPORTING PERSONS
             I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (Entities Only).
                      Sofinnova Venture Principals V, LP ("SVPr V")

- ------------ ---------------------------------------------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
                                                                                    (a)              (b)  X
- ------------ ---------------------------------------------------------------------------------------------------------
3            SEC USE ONLY

- ------------ ---------------------------------------------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION

             Delaware
- ------------ ---------------------------------------------------------------------------------------------------------

                                     5        SOLE VOTING POWER
             NUMBER OF                        50,321 shares, except that SM V, the general partner of SVPr V, may be
              SHARES                          deemed to have sole voting power, and Powell, Azan and Healy, the
           BENEFICIALLY                       managing members of SM V, may be deemed to have shared power to vote
      OWNED BY EACH REPORTING                 these shares.
              PERSON
               WITH
                                     -------- ------------------------------------------------------------------------
                                     6        SHARED VOTING POWER
                                              See response to row 5.
                                     -------- ------------------------------------------------------------------------
                                     7        SOLE DISPOSITIVE POWER
                                              50,321 shares, except that SM V, the general partner of SVPr V, may be
                                              deemed to have sole dispositive power, and Powell, Azan and Healy, the
                                              managing members of SM V, may be deemed to have shared power to
                                              dispose of these shares.
                                     -------- ------------------------------------------------------------------------
                                     8        SHARED DISPOSITIVE POWER
                                              See response to row 7.
- ------------------------------------ -------- ------------------------------------------------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON                                                                       50,321
- ------------ ---------------------------------------------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES (See Instructions)                                                [ ]
- ------------ ---------------------------------------------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
                                                                                                    0.1%
- ------------ ---------------------------------------------------------------------------------------------------------
12           TYPE OF REPORTING PERSON (See Instructions)
                                                                                                    PN
- ------------ ---------------------------------------------------------------------------------------------------------




- ----------------------------------------------------------                     --------------------------------------
CUSIP NO. 12345A678                                               13 G                                Page  5 of 15
- ----------------------------------------------------------                     --------------------------------------

- ------------ ---------------------------------------------------------------------------------------------------------
                               
1            NAME OF REPORTING PERSONS
             I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (Entities Only).
                      Sofinnova Management V, L.L.C. ("SM V")

- ------------ ---------------------------------------------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
                                                                                    (
a)              (b)  X
- ------------ ---------------------------------------------------------------------------------------------------------
3            SEC USE ONLY

- ------------ ---------------------------------------------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION

             Delaware
- ------------ ---------------------------------------------------------------------------------------------------------

                                     5        SOLE VOTING POWER
             NUMBER OF
              SHARES                          158,295 shares, of which 107,974 shares are owned directly by SVA V
           BENEFICIALLY                       and 50,321 shares are owned directly by SVPr V.  SM V, the general
      OWNED BY EACH REPORTING                 partner of SVA V and SVPr V, may be deemed to have sole voting over
              PERSON                          the shares owned directly by SVA V and SVPr V, and Powell, Azan and
               WITH                           Healy, the managing members of SM V, may be deemed to have shared
                                              power to vote these shares.
                                     -------- ------------------------------------------------------------------------
                                     6        SHARED VOTING POWER
                                              3,281,905 shares owned directly by SVP V.  SM V and SM V 2005, the
                                              general partners of SVP V, may be deemed to have shared voting power
                                              over the shares owned directly by SVA V, and Powell, Azan and Healy,
                                              the managing members of both SM V and SM V 2005, may be deemed to have
                                              shared power to vote these shares.
                                     -------- ------------------------------------------------------------------------
                                     7        SOLE DISPOSITIVE POWER
                                              158,295 shares, of which 107,974 shares are owned directly by SVA V
                                              and 50,321 shares are owned directly by SVPr V.  SM V, the general
                                              partner of SVA V and SVPr V, may be deemed to have sole dispositive
                                              power over the shares owned directly by SVA V and SVPr V, and Powell,
                                              Azan and Healy, the managing members of SM V, may be deemed to have
                                              shared power to dispose of these shares.
                                     -------- ------------------------------------------------------------------------
                                     8        SHARED DISPOSITIVE POWER
                                              3,281,905 shares owned directly by SVP V.  SM V and SM V 2005, the
                                              general partners of SVP V, may be deemed to have shared dispositive
                                              power over the shares owned directly by SVA V, and Powell, Azan and
                                              Healy, the managing members of both SM V and SM V 2005, may be deemed
                                              to have shared power to dispose of these shares.
- ------------------------------------ -------- ------------------------------------------------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON                                                                       3,440,200
- ------------ ---------------------------------------------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES (See Instructions)                                               [ ]
- ------------ ---------------------------------------------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
                                                                                                    9.2%
- ------------ ---------------------------------------------------------------------------------------------------------
12           TYPE OF REPORTING PERSON (See Instructions)
                                                                                                    OO
- ------------ ---------------------------------------------------------------------------------------------------------




- ----------------------------------------------------------                     --------------------------------------
CUSIP NO. 12345A678                                               13 G                                Page  6 of 15
- ----------------------------------------------------------                     --------------------------------------

- ------------ ---------------------------------------------------------------------------------------------------------
                               
1            NAME OF REPORTING PERSONS
             I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (Entities Only).
                      Sofinnova Management V 2005 L.L.C. ("SMV 2005")

- ------------ ---------------------------------------------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
                                                                                    (a)              (b)  X
- ------------ ---------------------------------------------------------------------------------------------------------
3            SEC USE ONLY

- ------------ ---------------------------------------------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION

             Delaware
- ------------ ---------------------------------------------------------------------------------------------------------

                                     5        SOLE VOTING POWER
             NUMBER OF                        0
              SHARES
           BENEFICIALLY
      OWNED BY EACH REPORTING
              PERSON
               WITH
                                     -------- ------------------------------------------------------------------------
                                     6        SHARED VOTING POWER
                                              3,281,905 shares which are owned directly by SVP V.  SMV 2005 and SM
                                              V, the general partners of SVP V, may be deemed to have shared voting
                                              power, and Powell, Azan and Healy, the managing members of SMV 2005
                                              and SM V, may be deemed to have shared power to vote these shares.
                                     -------- ------------------------------------------------------------------------
                                     7        SOLE DISPOSITIVE POWER
                                              0
                                     -------- ------------------------------------------------------------------------
                                     8        SHARED DISPOSITIVE POWER
                                              3,281,905 shares which are owned directly by SVP V.  SMV 2005 and SM
                                              V, the general partners of SVP V, may be deemed to have shared
                                              dispositive power, and Powell, Azan and Healy, the managing members of
                                              SMV 2005 and SM V, may be deemed to have shared power to dispose of
                                              these shares.
- ------------------------------------ -------- ------------------------------------------------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON                                                                       3,281,905
- ------------ ---------------------------------------------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES (See Instructions)                                                 [ ]
- ------------ ---------------------------------------------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
                                                                                                    8.8%
- ------------ ---------------------------------------------------------------------------------------------------------
12           TYPE OF REPORTING PERSON (See Instructions)
                                                                                                    OO
- ------------ ---------------------------------------------------------------------------------------------------------




- ----------------------------------------------------------                     --------------------------------------
CUSIP NO. 12345A678                                               13 G                                Page  7 of 15
- ----------------------------------------------------------                     --------------------------------------

- ------------ --------------------------------------------------------------------------------------------------------
                               
1            NAME OF REPORTING
             SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
                      Michael F. Powell ("Powell")
                      Tax ID Number:
- ------------ --------------------------------------------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                                    (a)              (b)  X
- ------------ --------------------------------------------------------------------------------------------------------
3            SEC USE ONLY

- ------------ --------------------------------------------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION

             U.S. Citizen
- ------------ --------------------------------------------------------------------------------------------------------

                                     5        SOLE VOTING POWER
                                              11,250 shares (issuable to Powell pursuant to outstanding options
             NUMBER OF                        exercisable within 60 days of December 31, 2005).
              SHARES                 -------- -----------------------------------------------------------------------
           BENEFICIALLY              6        SHARED VOTING POWER
      OWNED BY EACH REPORTING                 3,440,200 shares, of which 3,281,905 shares are owned directly by SVP
              PERSON                          V, 107,974 shares are owned directly by SVA V and 50,321 shares are
               WITH                           owned directly by SVPr V. SM V is the general partner of SVA V and
                                              SVPr V, and Powell, a managing member of SM V, may be deemed to have
                                              shared power to vote the shares held by SVA V and SVPr V.  SM V and
                                              SMV 2005 are general partners of SVP V, and Powell, a managing member
                                              of both SM V and SMV 2005, may be deemed to have shared power to vote
                                              the shares held by SVP V.
                                     -------- -----------------------------------------------------------------------
                                     7        SOLE DISPOSITIVE POWER
                                              11,250 shares (issuable to Powell pursuant to outstanding options
                                              exercisable within 60 days of December 31, 2005).
                                     -------- -----------------------------------------------------------------------
                                     8        SHARED DISPOSITIVE POWER
                                              3,440,200 shares, of which 3,281,905 shares are owned directly by SVP
                                              V, 107,974 shares are owned directly by SVA V and 50,321 shares are
                                              owned directly by SVPr V. SM V is the general partner of SVA V and
                                              SVPr V, and Powell, a managing member of SM V, may be deemed to have
                                              shared power to dispose of the shares held by SVA V and SVPr V.  SM V
                                              and SMV 2005 are general partners of SVP V, and Powell, a managing
                                              member of both SM V and SMV 2005, may be deemed to have shared power
                                              to dispose of the shares held by SVP V.
- ------------------------------------ -------- -----------------------------------------------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON                                                                3,451,450 shares.
- ------------ --------------------------------------------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES*                                                                  [ ]
- ------------ --------------------------------------------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                                                      9.3%
- ------------ --------------------------------------------------------------------------------------------------------
12           TYPE OF REPORTING PERSON*
                                                                                                      IN
- ----------- --------------------------------------------------------------------------------------------------------




- ----------------------------------------------------------                     --------------------------------------
CUSIP NO. 12345A678                                               13 G                                Page  8 of 15
- ----------------------------------------------------------                     --------------------------------------

- ------------ --------------------------------------------------------------------------------------------------------
                               
1            NAME OF REPORTING
             SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
                      Alain L. Azan ("Azan")
                      Tax ID Number:
- ------------ --------------------------------------------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                                    (a)              (b)  X
- ------------ --------------------------------------------------------------------------------------------------------
3            SEC USE ONLY

- ------------ --------------------------------------------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION

             U.S. Citizen
- ------------ --------------------------------------------------------------------------------------------------------

                                     5        SOLE VOTING POWER
                       
                       0 shares.
             NUMBER OF
              SHARES                 -------- -----------------------------------------------------------------------
           BENEFICIALLY              6        SHARED VOTING POWER
      OWNED BY EACH REPORTING                 3,440,200 shares, of which 3,281,905 shares are owned directly by SVP
              PERSON                          V, 107,974 shares are owned directly by SVA V and 50,321 shares are
               WITH                           owned directly by SVPr V. SM V is the general partner of SVA V and
                                              SVPr V, and Azan, a managing member of SM V, may be deemed to have
                                              shared power to vote the shares held by SVA V and SVPr V.  SM V and
                                              SMV 2005 are general partners of SVP V, and Azan, a managing member
                                              of both SM V and SMV 2005, may be deemed to have shared power to vote
                                              the shares held by SVP V.
                                     -------- -----------------------------------------------------------------------
                                     7        SOLE DISPOSITIVE POWER
                                              0 shares
                                     -------- -----------------------------------------------------------------------
                                     8        SHARED DISPOSITIVE POWER
                                              3,440,200 shares, of which 3,281,905 shares are owned directly by SVP
                                              V, 107,974 shares are owned directly by SVA V and 50,321 shares are
                                              owned directly by SVPr V. SM V is the general partner of SVA V and
                                              SVPr V, and Azan, a managing member of SM V, may be deemed to have
                                              shared power to dispose of the shares held by SVA V and SVPr V.  SM V
                                              and SMV 2005 are general partners of SVP V, and Azan, a managing
                                              member of both SM V and SMV 2005, may be deemed to have shared power
                                              to dispose of the shares held by SVP V.
- ------------------------------------ -------- -----------------------------------------------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON                                                             3,440,200 shares.
- ------------ --------------------------------------------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES*                                                          [ ]
- ------------ --------------------------------------------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                                                9.2%
- ------------ --------------------------------------------------------------------------------------------------------
12           TYPE OF REPORTING PERSON*
                                                                                                IN
- ------------ --------------------------------------------------------------------------------------------------------





- ----------------------------------------------------------                     --------------------------------------
CUSIP NO. 12345A678                                               13 G                                Page  9 of 15
- ----------------------------------------------------------                     --------------------------------------

- ------------ --------------------------------------------------------------------------------------------------------
                               
1            NAME OF REPORTING
             SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

             James I. Healy, M.D., Ph.D. ("Healy")
                      Tax ID Number:
- ------------ --------------------------------------------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                                    (a)              (b)  X
- ------------ --------------------------------------------------------------------------------------------------------
3            SEC USE ONLY

- ------------ --------------------------------------------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION

             U.S. Citizen
- ------------ --------------------------------------------------------------------------------------------------------

                                     5        SOLE VOTING POWER
                                              0 shares.
             NUMBER OF
              SHARES                 -------- -----------------------------------------------------------------------
           BENEFICIALLY              6        SHARED VOTING POWER
      OWNED BY EACH REPORTING                 3,440,200 shares, of which 3,281,905 shares are owned directly by SVP
              PERSON                          V, 107,974 shares are owned directly by SVA V and 50,321 shares are
               WITH                           owned directly by SVPr V. SM V is the general partner of SVA V and
                                              SVPr V, and Healey, a managing member of SM V, may be deemed to have
                                              shared power to vote the shares held by SVA V and SVPr V.  SM V and
                                              SMV 2005 are general partners of SVP V, and Healey, a managing member
                                              of both SM V and SMV 2005, may be deemed to have shared power to vote
                                              the shares held by SVP V.
                                     -------- -----------------------------------------------------------------------
                                     7        SOLE DISPOSITIVE POWER
                                              0 shares
                                     -------- -----------------------------------------------------------------------
                                     8        SHARED DISPOSITIVE POWER
                                              3,440,200 shares, of which 3,281,905 shares are owned directly by SVP
                                              V, 107,974 shares are owned directly by SVA V and 50,321 shares are
                                              owned directly by SVPr V. SM V is the general partner of SVA V and
                                              SVPr V, and Healey, a managing member of SM V, may be deemed to have
                                              shared power to dispose of the shares held by SVA V and SVPr V.  SM V
                                              and SMV 2005 are general partners of SVP V, and Healey, a managing
                                              member of both SM V and SMV 2005, may be deemed to have shared power
                                              to dispose of the shares held by SVP V.
- ------------------------------------ -------- -----------------------------------------------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON                                                            3,440,200 shares.
- ------------ --------------------------------------------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES*                                                           [ ]
- ------------ --------------------------------------------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                                             9.2%
- ------------ --------------------------------------------------------------------------------------------------------
12           TYPE OF REPORTING PERSON*
                                                                                              IN
- ------------ --------------------------------------------------------------------------------------------------------


- ------------------------------------                     -----------------------
CUSIP NO. 12345A678                         13 G               Page  10 of 15
- ------------------------------------                     -----------------------


ITEM 1(A).        NAME OF ISSUER
                  --------------

                  Threshold Pharmaceuticals, Inc.

ITEM 1(B).        ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES
                  -----------------------------------------------

                  1300 Seaport Boulevard
                  Redwood City, CA 94063

ITEM 2(A).        NAME OF PERSONS FILING
                  ----------------------

                  This Statement is filed by Sofinnova  Venture Partners V, L.P.
                  ("SVP V"),  Sofinnova  Venture  Affiliates V, L.P.  ("SVA V"),
                  Sofinnova  Venture  Principals V, L.P.  ("SVPr V"),  Sofinnova
                  Management V, L.L.C. ("SM V"), Sofinnova Management V 2005 LLC
                  ("SMV  2005"),  Michael F.  Powell  ("Powell"),  Alain L. Azan
                  ("Azan")  and James I.  Healy,  M.D.,  Ph.D.  ("Healey")  (the
                  "Reporting  Person").  The foregoing  entities and individuals
                  are collectively referred to as the "Reporting Persons."

                  SM V, the  general  partner of SVA V and SVPr V, may be deemed
                  to have sole power to vote and sole power to dispose of shares
                  of the issuer directly owned by SVA V and SVPr V. Powell, Azan
                  and Healey are the managing  members of SM V and may be deemed
                  to have  shared  power to vote and shared  power to dispose of
                  shares of the issuer directly owned by SVA V and SVPr V.

                  SM V and SMV  2005,  the  general  partners  of SVP V,  may be
                  deemed  to have  shared  power  to vote  and  shared  power to
                  dispose  of  shares  of the  issuer  directly  owned by SVP V.
                  Powell,  Azan and Healey are the  managing  members of SMV and
                  SMV 2005 and may be  deemed to have  shared  power to vote and
                  shared power to dispose of shares of the issuer directly owned
                  by SVP V.

ITEM 2(B).        ADDRESS OF PRINCIPAL BUSINESS OFFICE
                  ------------------------------------

                  The address for each of the Reporting Persons is:

                  Sofinnova Ventures Inc.
                  140 Geary Street, 10th Floor
                  San Francisco, California  94108

ITEM 2(C)         CITIZENSHIP
                  -----------

                  SVP V, SVA V and SVPr V, are Delaware limited partnerships. SM
                  V and SMV 2005 are a  Delaware  limited  liability  companies.
                  Powell, Azan and Healy are United States citizens.

ITEM 2(D) AND (E).         TITLE OF CLASS OF SECURITIES AND CUSIP NUMBER
                           ---------------------------------------------

                  Common Stock
                  CUSIP # 885807-107

ITEM 3.           Not Applicable.
                  ---------------


ITEM 4.           OWNERSHIP
                  ---------

                  Provide the  following  information  regarding  the  aggregate
                  number and percentage of the class of securities of the issuer
                  identified in Item 1.


- ------------------------------------                     -----------------------
CUSIP NO. 12345A678                         13 G               Page  11 of 15
- ------------------------------------                     -----------------------


                      (a)   Amount beneficially owned:
                            --------------------------

                            See Row 9 of cover page for each Reporting Person.

                      (b)   Percent of Class:
                            -----------------

                            See Row 11 of cover page for each Reporting Person.

                      (c)   Number of shares as to which such person has:
                            ---------------------------------------------

                                  (i) Sole power to vote or to direct the vote:
                                      -----------------------------------------

                                       See  Row  5  of   cover   page  for  each
                                       Reporting Person.

                                  (ii) Shared  power  to vote or to  direct  the
                                       ----------------------------------------
                                       vote:
                                       -----

                                       See  Row  6  of   cover   page  for  each
                                       Reporting Person.

                                  (iii) Sole  power to  dispose or to direct the
                                        ----------------------------------------
                                        disposition of:
                                        ---------------

                                       See  Row  7  of   cover   page  for  each
                                       Reporting Person.

                                  (iv) Shared  power to dispose or to direct the
                                       -----------------------------------------
                                       disposition of:
                                       ---------------

                                       See  Row  8  of   cover   page  for  each
                                       Reporting Person.

ITEM 5.           OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS
                  --------------------------------------------

                  Not applicable.

ITEM 6.           OWNERSHIP  OF MORE THAN  FIVE  PERCENT  ON  BEHALF OF  ANOTHER
                  --------------------------------------------------------------
                  PERSON.
                  -------

                  Under   certain   circumstances   set  forth  in  the  limited
                  partnership  agreements  of SVP V,  SVA V and  SVPr V, and the
                  limited liability company agreements of SM V and SMV 2005, the
                  general and limited  partners or members,  as the case may be,
                  of each of such  entities  may be  deemed to have the right to
                  receive  dividends  from,  or the proceeds  from,  the sale of
                  shares of the issuer  owned by each such  entity of which they
                  are a partner or member, as the case may be.


- ------------------------------------                     -----------------------
CUSIP NO. 12345A678                         13 G               Page  12 of 15
- ------------------------------------                     -----------------------


ITEM 7.           IDENTIFICATION  AND  CLASSIFICATION  OF THE  SUBSIDIARY  WHICH
                  --------------------------------------------------------------
                  ACQUIRED THE SECURITY  BEING REPORTED ON BY THE PARENT HOLDING
                  --------------------------------------------------------------
                  COMPANY
                  -------

                  Not applicable.


ITEM 8.           IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP.
                  -----------------
-----------------------------------------

                  Not applicable.

ITEM 9.           NOTICE OF DISSOLUTION OF GROUP.
                  -------------------------------

                  Not applicable.

ITEM 10.          CERTIFICATION.
                  --------------

                  Not applicable.



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CUSIP NO. 12345A678                         13 G               Page  13 of 15
- ------------------------------------                     -----------------------

                                   SIGNATURES


     After  reasonable  inquiry and to the best of my  knowledge  and belief,  I
certify that the information  set forth in this statement is true,  complete and
correct.


Date:  February __, 2006


Sofinnova Venture Partners V, L.P.                  /s/ James I. Healy
By Sofinnova Management V, L.L.C.                   ----------------------------
By Sofinnova Management V 2005 L.L.C.               James I. Healy, Member
Its General Partners





Sofinnova Venture Affiliates V, L.P.                /s/ James I. Healy
By Sofinnova Management V, L.L.C.                   ----------------------------
Its General Partner                                 James I. Healy, Member





Sofinnova Venture Principals V, L.P.                /s/ James I. Healy
By Sofinnova Management V, L.L.C.                   ----------------------------
Its General Partner                                 James I. Healy, Member





Michael F. Powell                                   /s/ Michael F. Powell
                                                    ----------------------------
                                                    Michael F. Powell





Alain L. Azan                                       /s/ Alain L. Azan
                                                    ----------------------------
                                                    Alain L. Azan





James I. Healey, M.D., Ph.D.                        /s/ James I. Healey
                                                    ----------------------------
                                                    James I. Healey





The  original  statement  shall be signed by each  person  on whose  behalf  the
statement is filed or his authorized representative.  If the statement is signed
on behalf of a person by his authorized  representative  other than an executive
officer  or   general   partner  of  the   filing   person,   evidence   of  the
representative's  authority to sign on behalf of such person shall be filed with
the  statement,  provided,  however,  that a power of attorney  for this purpose
which is already on file with the Commission may be  incorporated  by reference.
The name and any title of each person who signs the statement  shall be typed or
printed  beneath his  signature.  NOTE:  Schedules  filed in paper  format shall
include  a signed  original  and five  copies  of the  schedule,  including  all
exhibits. See ss.240.13d-7 for other parties for whom copies are to be sent.

Attention:  Intentional  misstatements  or omissions of fact constitute  Federal
criminal violations (See 18 U.S.C. 1001)


- ------------------------------------                     -----------------------
CUSIP NO. 12345A678                         13 G               Page  14 of 15
- ------------------------------------                     -----------------------


                                  EXHIBIT INDEX
                                  -------------


                                                                Found on
                                                              Sequentially
Exhibit                                                       Numbered Page
- -------                                                       -------------

Exhibit A:  Agreement of Joint Filing                              19




- ------------------------------------                     -----------------------
CUSIP NO. 12345A678                         13 G               Page  15 of 15
- ------------------------------------                     -----------------------


                                    EXHIBIT A
                                    ---------


                            Agreement of Joint Filing
                            -------------------------


The  undersigned  hereby  agree  that a single  Schedule  13G (or any  amendment
thereto) relating to the Common Stock of Threshold  Pharmaceuticals,  Inc. shall
be filed on behalf of each of the  undersigned  and that this Agreement shall be
filed as an exhibit to such Schedule 13G.


Date:  February __, 2006


Sofinnova Venture Partners V, L.P.                  /s/ James I. Healey
By Sofinnova Management V, L.L.C.                   ----------------------------
By Sofinnova Management V 2005 L.L.C.               James I. Healy, Member
Its General Partners




Sofinnova Venture Affiliates V, L.P.                /s/ James I. Healey
By Sofinnova Management V, L.L.C.                   ----------------------------
Its General Partner                                 James I. Healy, Member



Sofinnova Venture Principals V, L.P.                /s/ James I. Healey
By Sofinnova Management V, L.L.C.                   ----------------------------
Its General Partner                                 James I. Healy, Member


Michael F. Powell                                   /s/ Michael F. Powell
                                                    ----------------------------
                                                    Michael F. Powell



Alain L. Azan                                       /s/ Alain L. Azan
                                                    ----------------------------
                                                    Alain L. Azan



James I. Healey, M.D., Ph.D.                        /s/ James I. Healey
                                                    ----------------------------
                                                    James I. Healey